Hetero-stereocomplexes of d-poly(lactic acid) and the LHRH analogue leuprolide. Application in controlled release

Reversible hetero-stereoselective complexes were obtained by mixing acetonitrile solutions of enantiomeric d-poly(lactic acid) ( d-PLA) and leuprolide, an l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (95%) from acetonitrile solutions, f...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2004-11, Vol.58 (3), p.461-469
Hauptverfasser:	Slager, Joram, Domb, Abraham J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopolymers - chemistry Biopolymers - pharmacokinetics Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - pharmacokinetics Lactic Acid - chemistry Lactic Acid - pharmacokinetics Leuprolide Leuprolide - chemistry Leuprolide - pharmacokinetics LHRH release Male Peptide release Poly(lactide) Polyesters Polymers - chemistry Polymers - pharmacokinetics Rats Rats, Wistar Stereocomplex Stereoisomerism
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