T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis
BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2004-11, Vol.113 (2), p.179-186 |
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| creator | Hacker-Foegen, Mary K. Zillikens, Detlef Giudice, George J. Lin, Mong-Shang |
| description | BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases. |
| doi_str_mv | 10.1016/j.clim.2004.08.003 |
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Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2004.08.003</identifier><identifier>PMID: 15451475</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Autoantigens - immunology ; Autoimmunity ; Base Sequence ; Biological and medical sciences ; BP180 ; Cells, Cultured ; Clone Cells ; Collagen Type XVII ; Epitope Mapping ; Epitopes, T-Lymphocyte - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genes, T-Cell Receptor ; Humans ; Immunopathology ; Medical sciences ; Molecular Sequence Data ; Non-Fibrillar Collagens - immunology ; Pemphigoid ; Pemphigoid, Bullous - immunology ; Polymerase Chain Reaction ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; T cell receptor ; T-Lymphocytes - immunology</subject><ispartof>Clinical immunology (Orlando, Fla.), 2004-11, Vol.113 (2), p.179-186</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-a9b9c5394dd619be7da99839ef074ff27e19f6ba96c31855a36c0004e2b61393</citedby><cites>FETCH-LOGICAL-c413t-a9b9c5394dd619be7da99839ef074ff27e19f6ba96c31855a36c0004e2b61393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661604002438$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16173642$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15451475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hacker-Foegen, Mary K.</creatorcontrib><creatorcontrib>Zillikens, Detlef</creatorcontrib><creatorcontrib>Giudice, George J.</creatorcontrib><creatorcontrib>Lin, Mong-Shang</creatorcontrib><title>T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.</description><subject>Amino Acid Sequence</subject><subject>Autoantigens - immunology</subject><subject>Autoimmunity</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BP180</subject><subject>Cells, Cultured</subject><subject>Clone Cells</subject><subject>Collagen Type XVII</subject><subject>Epitope Mapping</subject><subject>Epitopes, T-Lymphocyte - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes, T-Cell Receptor</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Non-Fibrillar Collagens - immunology</subject><subject>Pemphigoid</subject><subject>Pemphigoid, Bullous - immunology</subject><subject>Polymerase Chain Reaction</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>T cell receptor</subject><subject>T-Lymphocytes - immunology</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhosozjj6B1xINrprzUmatAE3OvgFA7q4-5CmJ3dyaZuatMrFP2_KLYwrXSWB55y85zxF8RJoBRTk21NlBz9WjNK6om1FKX9UXINgUDaUi8f7XUqQV8WzlE6UUsGYfFpcgagF1I24Ln4fiMVhIBEtzkuI5IgTkjWZI5LgyIfv0NIyzWi985YcyHAe5_tgzwsm4mIYyWwWj9OSyC-_3JNuHYawJjJjxvwx-J6Yqf_7ecS05JIw-fS8eOLMkPDFft4Uh08fD7dfyrtvn7_evr8rbQ18KY3qlBVc1X0vQXXY9Eaplit0tKmdYw2CcrIzSloOrRCGS5tHrZF1ErjiN8WbS9s5hh9r_l6PPm1DmwlzVi2lglox9l8QmqZtgW4d2QW0MaQU0ek5-tHEswaqNzX6pDc1elOjaauzmlz0au--diP2DyW7iwy83gGTrBlcNJP16YGT0HBZbzHfXTjMO_vpMepkswKLvc8WF90H_68cfwCO_q16</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Hacker-Foegen, Mary K.</creator><creator>Zillikens, Detlef</creator><creator>Giudice, George J.</creator><creator>Lin, Mong-Shang</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis</title><author>Hacker-Foegen, Mary K. ; Zillikens, Detlef ; Giudice, George J. ; Lin, Mong-Shang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-a9b9c5394dd619be7da99839ef074ff27e19f6ba96c31855a36c0004e2b61393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Autoantigens - immunology</topic><topic>Autoimmunity</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BP180</topic><topic>Cells, Cultured</topic><topic>Clone Cells</topic><topic>Collagen Type XVII</topic><topic>Epitope Mapping</topic><topic>Epitopes, T-Lymphocyte - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes, T-Cell Receptor</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Non-Fibrillar Collagens - immunology</topic><topic>Pemphigoid</topic><topic>Pemphigoid, Bullous - immunology</topic><topic>Polymerase Chain Reaction</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>T cell receptor</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hacker-Foegen, Mary K.</creatorcontrib><creatorcontrib>Zillikens, Detlef</creatorcontrib><creatorcontrib>Giudice, George J.</creatorcontrib><creatorcontrib>Lin, Mong-Shang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hacker-Foegen, Mary K.</au><au>Zillikens, Detlef</au><au>Giudice, George J.</au><au>Lin, Mong-Shang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>113</volume><issue>2</issue><spage>179</spage><epage>186</epage><pages>179-186</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>BP180 is the autoantigen of different immunobullous diseases, including bullous pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells, indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-specific T cell clones derived from these patients were shown to express a CD4+ memory T cell phenotype and secrete cytokines that may promote autoantibody production. In this study, we further characterize the properties of these T cells by analyzing their epitope specificity and T cell receptor (TCR) gene usage. We discovered that 83% of T cell clones obtained from BP patients preferentially express TCRBV13, while clones derived from a PG patient express the TCRBV3 gene. However, no preferential TCRBJ gene usage was identified. In conclusion, our results provide an advanced understanding of the characteristics of autoimmune T cells in immunobullous diseases.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>15451475</pmid><doi>10.1016/j.clim.2004.08.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Amino Acid Sequence Autoantigens - immunology Autoimmunity Base Sequence Biological and medical sciences BP180 Cells, Cultured Clone Cells Collagen Type XVII Epitope Mapping Epitopes, T-Lymphocyte - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, T-Cell Receptor Humans Immunopathology Medical sciences Molecular Sequence Data Non-Fibrillar Collagens - immunology Pemphigoid Pemphigoid, Bullous - immunology Polymerase Chain Reaction Receptors, Antigen, T-Cell, alpha-beta - genetics T cell receptor T-Lymphocytes - immunology |
| title | T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis |
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