Cyclodextrin enhanced transdermal delivery of piroxicam and carboxyfluorescein by electroporation
The transdermal transport of cyclodextrins (CD) across porcine epidermis by electroporation was studied. Electroporation increased the permeation of β-cyclodextrin (BCD) and hydroxy propyl β-cyclodextrin (HPCD) by several orders of magnitude, relative to passive transport. The presence of BCD and HP...
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| Veröffentlicht in: | Journal of controlled release 2004-10, Vol.99 (3), p.393-402 |
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| creator | Murthy, S. Narasimha Zhao, Ya-Li Sen, Arindam Hui, Sek Wen |
| description | The transdermal transport of cyclodextrins (CD) across porcine epidermis by electroporation was studied. Electroporation increased the permeation of β-cyclodextrin (BCD) and hydroxy propyl β-cyclodextrin (HPCD) by several orders of magnitude, relative to passive transport. The presence of BCD and HPCD enhanced the total transport of the test permeants piroxicam and carboxyfluorescein (CF), respectively, from both permeant solutions and suspensions. BCD enhanced the fraction of piroxicam transported across the epidermis into the receiver compartment medium. This was most likely due to the prolonged post-pulse permeability state of the epidermis. The fraction of CF retained in the epidermis was increased by HPCD. The rate of diffusion of CF from epidermis into the receiver compartment was decreased by the presence of HPCD, apparently due to the aggregate forming tendency of HPCD. The in vivo delivery of CF by electroporation in mice demonstrated the potential of HPCD for sustaining the transdermal absorption rate of hydrophilic molecules. |
| doi_str_mv | 10.1016/j.jconrel.2004.07.026 |
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Narasimha ; Zhao, Ya-Li ; Sen, Arindam ; Hui, Sek Wen</creator><creatorcontrib>Murthy, S. Narasimha ; Zhao, Ya-Li ; Sen, Arindam ; Hui, Sek Wen</creatorcontrib><description>The transdermal transport of cyclodextrins (CD) across porcine epidermis by electroporation was studied. Electroporation increased the permeation of β-cyclodextrin (BCD) and hydroxy propyl β-cyclodextrin (HPCD) by several orders of magnitude, relative to passive transport. The presence of BCD and HPCD enhanced the total transport of the test permeants piroxicam and carboxyfluorescein (CF), respectively, from both permeant solutions and suspensions. BCD enhanced the fraction of piroxicam transported across the epidermis into the receiver compartment medium. This was most likely due to the prolonged post-pulse permeability state of the epidermis. The fraction of CF retained in the epidermis was increased by HPCD. The rate of diffusion of CF from epidermis into the receiver compartment was decreased by the presence of HPCD, apparently due to the aggregate forming tendency of HPCD. The in vivo delivery of CF by electroporation in mice demonstrated the potential of HPCD for sustaining the transdermal absorption rate of hydrophilic molecules.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2004.07.026</identifier><identifier>PMID: 15451597</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>2-Hydroxypropyl-beta-cyclodextrin ; Administration, Cutaneous ; Animals ; beta-Cyclodextrins - chemistry ; beta-Cyclodextrins - pharmacokinetics ; Biological and medical sciences ; Biological Transport - drug effects ; Biological Transport - physiology ; Carboxyfluorescein ; Cyclodextrin ; Diffusion - drug effects ; Drug Carriers - chemistry ; Drug Carriers - pharmacokinetics ; Electroporation ; Electroporation - methods ; Electroporation - trends ; Fluoresceins - chemistry ; Fluoresceins - pharmacokinetics ; General pharmacology ; Hydroxypropyl β-cyclodextrin ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Piroxicam ; Piroxicam - administration & dosage ; Piroxicam - chemistry ; Piroxicam - pharmacokinetics ; Porcine epidermis ; Skin - drug effects ; Skin - metabolism ; Skin - pathology ; Skin Absorption - drug effects ; Skin Absorption - physiology ; Surface-Active Agents - chemistry ; Surface-Active Agents - pharmacokinetics ; Sustained release ; Swine ; β cyclodextrin</subject><ispartof>Journal of controlled release, 2004-10, Vol.99 (3), p.393-402</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-520bd012f3790a59fcb39a97fc3b406e86ce6a269ed4ac5e763cc25eefa96d3c3</citedby><cites>FETCH-LOGICAL-c391t-520bd012f3790a59fcb39a97fc3b406e86ce6a269ed4ac5e763cc25eefa96d3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2004.07.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16173741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15451597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murthy, S. Narasimha</creatorcontrib><creatorcontrib>Zhao, Ya-Li</creatorcontrib><creatorcontrib>Sen, Arindam</creatorcontrib><creatorcontrib>Hui, Sek Wen</creatorcontrib><title>Cyclodextrin enhanced transdermal delivery of piroxicam and carboxyfluorescein by electroporation</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>The transdermal transport of cyclodextrins (CD) across porcine epidermis by electroporation was studied. Electroporation increased the permeation of β-cyclodextrin (BCD) and hydroxy propyl β-cyclodextrin (HPCD) by several orders of magnitude, relative to passive transport. The presence of BCD and HPCD enhanced the total transport of the test permeants piroxicam and carboxyfluorescein (CF), respectively, from both permeant solutions and suspensions. BCD enhanced the fraction of piroxicam transported across the epidermis into the receiver compartment medium. This was most likely due to the prolonged post-pulse permeability state of the epidermis. The fraction of CF retained in the epidermis was increased by HPCD. The rate of diffusion of CF from epidermis into the receiver compartment was decreased by the presence of HPCD, apparently due to the aggregate forming tendency of HPCD. The in vivo delivery of CF by electroporation in mice demonstrated the potential of HPCD for sustaining the transdermal absorption rate of hydrophilic molecules.</description><subject>2-Hydroxypropyl-beta-cyclodextrin</subject><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>beta-Cyclodextrins - chemistry</subject><subject>beta-Cyclodextrins - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Biological Transport - drug effects</subject><subject>Biological Transport - physiology</subject><subject>Carboxyfluorescein</subject><subject>Cyclodextrin</subject><subject>Diffusion - drug effects</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Electroporation</subject><subject>Electroporation - methods</subject><subject>Electroporation - trends</subject><subject>Fluoresceins - chemistry</subject><subject>Fluoresceins - pharmacokinetics</subject><subject>General pharmacology</subject><subject>Hydroxypropyl β-cyclodextrin</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Piroxicam</subject><subject>Piroxicam - administration & dosage</subject><subject>Piroxicam - chemistry</subject><subject>Piroxicam - pharmacokinetics</subject><subject>Porcine epidermis</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin Absorption - drug effects</subject><subject>Skin Absorption - physiology</subject><subject>Surface-Active Agents - chemistry</subject><subject>Surface-Active Agents - pharmacokinetics</subject><subject>Sustained release</subject><subject>Swine</subject><subject>β cyclodextrin</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E2v1CAUgGFiNN7x6k_QdKO7VigFhpUxE7-Sm7jRNaGHQ2RCywidm-m_l8k0uUtXbN5zOHkIectoxyiTH4_dEdKcMXY9pUNHVUd7-Yzs2F7xdtBaPCe72u1bLoW-I69KOVJKBR_US3LHxCCY0GpH7GGFmBxelhzmBuc_dgZ0zZLtXBzmycbGYQyPmNcm-eYUcroEsFNjZ9eAzWO6rD6eU8YCWDeMa4MRYcnplLJdQppfkxfexoJvtvee_P765dfhe_vw89uPw-eHFrhmSyt6OjrKes-VplZoDyPXVisPfByoxL0ElLaXGt1gQaCSHKAXiN5q6Tjwe_LhtveU098zlsVMod4Uo50xnYuRUjPeK11DcQshp1IyenPKYbJ5NYyaq605ms3WXG0NVaba1rl32wfncUL3NLVh1uD9FtgCNvpqCKE8dZIprgZWu0-3DivHY8BsCgS8uodc6YxL4T-n_AOL0Z3B</recordid><startdate>20041019</startdate><enddate>20041019</enddate><creator>Murthy, S. Narasimha</creator><creator>Zhao, Ya-Li</creator><creator>Sen, Arindam</creator><creator>Hui, Sek Wen</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041019</creationdate><title>Cyclodextrin enhanced transdermal delivery of piroxicam and carboxyfluorescein by electroporation</title><author>Murthy, S. Narasimha ; Zhao, Ya-Li ; Sen, Arindam ; Hui, Sek Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-520bd012f3790a59fcb39a97fc3b406e86ce6a269ed4ac5e763cc25eefa96d3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>2-Hydroxypropyl-beta-cyclodextrin</topic><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>beta-Cyclodextrins - chemistry</topic><topic>beta-Cyclodextrins - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Biological Transport - drug effects</topic><topic>Biological Transport - physiology</topic><topic>Carboxyfluorescein</topic><topic>Cyclodextrin</topic><topic>Diffusion - drug effects</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacokinetics</topic><topic>Electroporation</topic><topic>Electroporation - methods</topic><topic>Electroporation - trends</topic><topic>Fluoresceins - chemistry</topic><topic>Fluoresceins - pharmacokinetics</topic><topic>General pharmacology</topic><topic>Hydroxypropyl β-cyclodextrin</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Piroxicam</topic><topic>Piroxicam - administration & dosage</topic><topic>Piroxicam - chemistry</topic><topic>Piroxicam - pharmacokinetics</topic><topic>Porcine epidermis</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin Absorption - drug effects</topic><topic>Skin Absorption - physiology</topic><topic>Surface-Active Agents - chemistry</topic><topic>Surface-Active Agents - pharmacokinetics</topic><topic>Sustained release</topic><topic>Swine</topic><topic>β cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murthy, S. Narasimha</creatorcontrib><creatorcontrib>Zhao, Ya-Li</creatorcontrib><creatorcontrib>Sen, Arindam</creatorcontrib><creatorcontrib>Hui, Sek Wen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murthy, S. Narasimha</au><au>Zhao, Ya-Li</au><au>Sen, Arindam</au><au>Hui, Sek Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclodextrin enhanced transdermal delivery of piroxicam and carboxyfluorescein by electroporation</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2004-10-19</date><risdate>2004</risdate><volume>99</volume><issue>3</issue><spage>393</spage><epage>402</epage><pages>393-402</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>The transdermal transport of cyclodextrins (CD) across porcine epidermis by electroporation was studied. Electroporation increased the permeation of β-cyclodextrin (BCD) and hydroxy propyl β-cyclodextrin (HPCD) by several orders of magnitude, relative to passive transport. The presence of BCD and HPCD enhanced the total transport of the test permeants piroxicam and carboxyfluorescein (CF), respectively, from both permeant solutions and suspensions. BCD enhanced the fraction of piroxicam transported across the epidermis into the receiver compartment medium. This was most likely due to the prolonged post-pulse permeability state of the epidermis. The fraction of CF retained in the epidermis was increased by HPCD. The rate of diffusion of CF from epidermis into the receiver compartment was decreased by the presence of HPCD, apparently due to the aggregate forming tendency of HPCD. The in vivo delivery of CF by electroporation in mice demonstrated the potential of HPCD for sustaining the transdermal absorption rate of hydrophilic molecules.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15451597</pmid><doi>10.1016/j.jconrel.2004.07.026</doi><tpages>10</tpages></addata></record> |
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| subjects | 2-Hydroxypropyl-beta-cyclodextrin Administration, Cutaneous Animals beta-Cyclodextrins - chemistry beta-Cyclodextrins - pharmacokinetics Biological and medical sciences Biological Transport - drug effects Biological Transport - physiology Carboxyfluorescein Cyclodextrin Diffusion - drug effects Drug Carriers - chemistry Drug Carriers - pharmacokinetics Electroporation Electroporation - methods Electroporation - trends Fluoresceins - chemistry Fluoresceins - pharmacokinetics General pharmacology Hydroxypropyl β-cyclodextrin Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Piroxicam Piroxicam - administration & dosage Piroxicam - chemistry Piroxicam - pharmacokinetics Porcine epidermis Skin - drug effects Skin - metabolism Skin - pathology Skin Absorption - drug effects Skin Absorption - physiology Surface-Active Agents - chemistry Surface-Active Agents - pharmacokinetics Sustained release Swine β cyclodextrin |
| title | Cyclodextrin enhanced transdermal delivery of piroxicam and carboxyfluorescein by electroporation |
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