Ischemia-induced increase in long-term potentiation is warded off by specific calpain inhibitor PD150606

In the present study, the effect of specific, membrane-permeable calpain inhibitor, PD150606, was analysed on synaptic efficacy in in vitro brain slices experiments after ischemic insult of rats in vivo, and on cell viability in a glutamate excitotoxicity test in mouse cell culture. Bilateral common...

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Veröffentlicht in:	Brain research 2004-10, Vol.1024 (1), p.150-158
Hauptverfasser:	Farkas, Bence, Tantos, Agnes, Schlett, Katalin, Világi, Ildikó, Friedrich, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - pharmacology Acrylates - therapeutic use Animals Biological and medical sciences Brain Ischemia - drug therapy Brain Ischemia - enzymology Calpain activity Calpain inhibition Carotid ligation Cell culture Cell Survival - drug effects Cell Survival - physiology Glycoproteins - pharmacology Hippocampal slice In Vitro Techniques Long-Term Potentiation - drug effects Long-Term Potentiation - physiology LTP Male Medical sciences Neurology Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system
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