PHYTOCHROME-INTERACTING FACTOR 1 is a critical bHLH regulator of chlorophyll biosynthesis
Photosynthetic organisms must achieve a delicate balance between the light energy absorbed by chlorophyll and their capacity to channel that energy into productive photochemical reactions. Release of excess absorbed energy in the cell can cause lethal photooxidative damage. We identified a basic hel...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2004-09, Vol.305 (5692), p.1937-1941 |
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| container_end_page | 1941 |
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| container_issue | 5692 |
| container_start_page | 1937 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 305 |
| creator | Huq, E Al-Sady, B Hudson, M Kim, C Apel, K Quail, P.H |
| description | Photosynthetic organisms must achieve a delicate balance between the light energy absorbed by chlorophyll and their capacity to channel that energy into productive photochemical reactions. Release of excess absorbed energy in the cell can cause lethal photooxidative damage. We identified a basic helix-loop-helix (bHLH) transcription factor, designated PHYTOCHROME-INTERACTING FACTOR 1 (PIF1), that negatively regulates chlorophyll biosynthesis. pif1 mutant seedlings accumulate excess free protochlorophyllide when grown in the dark, with consequent lethal bleaching upon exposure to light. PIF1 interacts specifically with the photoactivated conformer of phytochromes A and B, suggesting a signaling pathway by which chlorophyll biosynthetic rates are tightly controlled during the critical initial emergence of seedlings from subterranean darkness into sunlight. |
| doi_str_mv | 10.1126/science.1099728 |
| format | Article |
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Release of excess absorbed energy in the cell can cause lethal photooxidative damage. We identified a basic helix-loop-helix (bHLH) transcription factor, designated PHYTOCHROME-INTERACTING FACTOR 1 (PIF1), that negatively regulates chlorophyll biosynthesis. pif1 mutant seedlings accumulate excess free protochlorophyllide when grown in the dark, with consequent lethal bleaching upon exposure to light. PIF1 interacts specifically with the photoactivated conformer of phytochromes A and B, suggesting a signaling pathway by which chlorophyll biosynthetic rates are tightly controlled during the critical initial emergence of seedlings from subterranean darkness into sunlight.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1099728</identifier><identifier>PMID: 15448264</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Arabidopsis ; Arabidopsis Proteins - physiology ; Arabidopsis thaliana ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology ; Basic Helix-Loop-Helix Transcription Factors ; Biological and medical sciences ; Biological Evolution ; Biosynthesis ; Botany ; Chemical properties ; Chlorophyll ; Chlorophyll - biosynthesis ; Chlorophylls ; Company growth ; DNA, Plant - metabolism ; DNA-Binding Proteins - physiology ; Energy ; Fundamental and applied biological sciences. Psychology ; Gene expression regulation ; Gene Expression Regulation, Plant ; Germination ; Growth ; Helix-Loop-Helix Motifs ; hypocotyl length ; Hypocotyls ; Light ; messenger RNA ; Metabolism ; Molecules ; mutants ; phenotype ; Phenotypes ; Photochemistry ; Photoreceptors ; Photosynthesis ; Phytochrome ; Phytochrome - physiology ; Plant cells ; Plant physiology and development ; Protein Binding ; protochlorophyllides ; Quails ; seedling growth ; Seedlings ; Seeds ; Signal Transduction ; Storage and secretion, pigments, phytochrome ; transcription (genetics) ; transcription factors ; Transcription Factors - physiology ; Transcription, Genetic ; transcriptional activation</subject><ispartof>Science (American Association for the Advancement of Science), 2004-09, Vol.305 (5692), p.1937-1941</ispartof><rights>Copyright 2004 American Association for the Advancement of Science</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2004 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 24, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c805t-7a54df6ff8f30e1067e30d0fc18cf8cc675967cde698a166ca7c71e1f17e93383</citedby><cites>FETCH-LOGICAL-c805t-7a54df6ff8f30e1067e30d0fc18cf8cc675967cde698a166ca7c71e1f17e93383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3837869$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3837869$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27928,27929,58021,58254</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16142210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15448264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huq, E</creatorcontrib><creatorcontrib>Al-Sady, B</creatorcontrib><creatorcontrib>Hudson, M</creatorcontrib><creatorcontrib>Kim, C</creatorcontrib><creatorcontrib>Apel, K</creatorcontrib><creatorcontrib>Quail, P.H</creatorcontrib><title>PHYTOCHROME-INTERACTING FACTOR 1 is a critical bHLH regulator of chlorophyll biosynthesis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Photosynthetic organisms must achieve a delicate balance between the light energy absorbed by chlorophyll and their capacity to channel that energy into productive photochemical reactions. Release of excess absorbed energy in the cell can cause lethal photooxidative damage. We identified a basic helix-loop-helix (bHLH) transcription factor, designated PHYTOCHROME-INTERACTING FACTOR 1 (PIF1), that negatively regulates chlorophyll biosynthesis. pif1 mutant seedlings accumulate excess free protochlorophyllide when grown in the dark, with consequent lethal bleaching upon exposure to light. PIF1 interacts specifically with the photoactivated conformer of phytochromes A and B, suggesting a signaling pathway by which chlorophyll biosynthetic rates are tightly controlled during the critical initial emergence of seedlings from subterranean darkness into sunlight.</description><subject>Arabidopsis</subject><subject>Arabidopsis Proteins - physiology</subject><subject>Arabidopsis thaliana</subject><subject>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Biosynthesis</subject><subject>Botany</subject><subject>Chemical properties</subject><subject>Chlorophyll</subject><subject>Chlorophyll - biosynthesis</subject><subject>Chlorophylls</subject><subject>Company growth</subject><subject>DNA, Plant - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Energy</subject><subject>Fundamental and applied biological sciences. 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physiology</topic><topic>Arabidopsis thaliana</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Biosynthesis</topic><topic>Botany</topic><topic>Chemical properties</topic><topic>Chlorophyll</topic><topic>Chlorophyll - biosynthesis</topic><topic>Chlorophylls</topic><topic>Company growth</topic><topic>DNA, Plant - metabolism</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Energy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression regulation</topic><topic>Gene Expression Regulation, Plant</topic><topic>Germination</topic><topic>Growth</topic><topic>Helix-Loop-Helix Motifs</topic><topic>hypocotyl length</topic><topic>Hypocotyls</topic><topic>Light</topic><topic>messenger RNA</topic><topic>Metabolism</topic><topic>Molecules</topic><topic>mutants</topic><topic>phenotype</topic><topic>Phenotypes</topic><topic>Photochemistry</topic><topic>Photoreceptors</topic><topic>Photosynthesis</topic><topic>Phytochrome</topic><topic>Phytochrome - physiology</topic><topic>Plant cells</topic><topic>Plant physiology and development</topic><topic>Protein Binding</topic><topic>protochlorophyllides</topic><topic>Quails</topic><topic>seedling growth</topic><topic>Seedlings</topic><topic>Seeds</topic><topic>Signal Transduction</topic><topic>Storage and secretion, pigments, phytochrome</topic><topic>transcription (genetics)</topic><topic>transcription factors</topic><topic>Transcription Factors - 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reactions. Release of excess absorbed energy in the cell can cause lethal photooxidative damage. We identified a basic helix-loop-helix (bHLH) transcription factor, designated PHYTOCHROME-INTERACTING FACTOR 1 (PIF1), that negatively regulates chlorophyll biosynthesis. pif1 mutant seedlings accumulate excess free protochlorophyllide when grown in the dark, with consequent lethal bleaching upon exposure to light. PIF1 interacts specifically with the photoactivated conformer of phytochromes A and B, suggesting a signaling pathway by which chlorophyll biosynthetic rates are tightly controlled during the critical initial emergence of seedlings from subterranean darkness into sunlight.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>15448264</pmid><doi>10.1126/science.1099728</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2004-09, Vol.305 (5692), p.1937-1941 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66910863 |
| source | MEDLINE; American Association for the Advancement of Science; JSTOR |
| subjects | Arabidopsis Arabidopsis Proteins - physiology Arabidopsis thaliana Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology Basic Helix-Loop-Helix Transcription Factors Biological and medical sciences Biological Evolution Biosynthesis Botany Chemical properties Chlorophyll Chlorophyll - biosynthesis Chlorophylls Company growth DNA, Plant - metabolism DNA-Binding Proteins - physiology Energy Fundamental and applied biological sciences. Psychology Gene expression regulation Gene Expression Regulation, Plant Germination Growth Helix-Loop-Helix Motifs hypocotyl length Hypocotyls Light messenger RNA Metabolism Molecules mutants phenotype Phenotypes Photochemistry Photoreceptors Photosynthesis Phytochrome Phytochrome - physiology Plant cells Plant physiology and development Protein Binding protochlorophyllides Quails seedling growth Seedlings Seeds Signal Transduction Storage and secretion, pigments, phytochrome transcription (genetics) transcription factors Transcription Factors - physiology Transcription, Genetic transcriptional activation |
| title | PHYTOCHROME-INTERACTING FACTOR 1 is a critical bHLH regulator of chlorophyll biosynthesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T13%3A21%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PHYTOCHROME-INTERACTING%20FACTOR%201%20is%20a%20critical%20bHLH%20regulator%20of%20chlorophyll%20biosynthesis&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Huq,%20E&rft.date=2004-09-24&rft.volume=305&rft.issue=5692&rft.spage=1937&rft.epage=1941&rft.pages=1937-1941&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1099728&rft_dat=%3Cgale_proqu%3EA123163078%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213579283&rft_id=info:pmid/15448264&rft_galeid=A123163078&rft_jstor_id=3837869&rfr_iscdi=true |