Thyroid Function and Cancer Risk: A Prospective Population Study
Background: It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical power have investigated this question, and the results have not been consistent. Methods: In a prospective study of 29,691 people (19,710 women and 9,981 men) without previ...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2009-02, Vol.18 (2), p.570-574 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | HELLEVIK, Alf Inge ASVOLD, Bjørn Olav BJØRO, Trine ROMUNDSTAD, Pal R NILSEN, Tom Ivar L VATTEN, Lars J |
| description | Background: It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical
power have investigated this question, and the results have not been consistent.
Methods: In a prospective study of 29,691 people (19,710 women and 9,981 men) without previously known thyroid disease, thyrotropin
was measured at baseline, and cancer incidence was recorded during 9 years of follow-up. Using Cox regression analysis, we
studied the associations (hazard ratios) of thyrotropin categories with total cancer risk, and specifically, with risk of
lung, colon, prostate, and breast cancer adjusted for age, sex, and smoking status.
Results: Low thyrotropin levels ( |
| doi_str_mv | 10.1158/1055-9965.EPI-08-0911 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66909647</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66909647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-51194ebdab53991ba75f149df2183f01c9dd616eb1a51bde83ab648418906acd3</originalsourceid><addsrcrecordid>eNpF0F1PwyAUgGFiNDqnP0HTG_Wqyml7KHjlsjg1WeLixzWhQF21ayesmv172Yd6BQnPAfIScgL0EgD5FVDEWAiGl7eTh5jymAqAHdIDTHmc54i7Yf9rDsih9--U0lwg7pMDEICYpaxHbl6mS9dWJhp1jV5UbROpxkRD1WjroqfKf1xHg2jiWj-34fjLRpN23tVqLZ8XnVkekb1S1d4eb9c-eR3dvgzv4_Hj3cNwMI51BmwRI4DIbGFUgakQUKgcS8iEKRPgaUlBC2MYMFuAQiiM5akqWMYz4IIypU3aJ-ebe-eu_eysX8hZ5bWta9XYtvOSMUEFy_IAcQN1-LV3tpRzV82UW0qgcpVOrrLIVRYZ0knK5SpdmDvdPtAVM2v-p7atAjjbAuW1qksXIlX-zyWQMMgTGtzFxk2rt-l35azU65zOequcnkrgMpGY0_QHHYeEAQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66909647</pqid></control><display><type>article</type><title>Thyroid Function and Cancer Risk: A Prospective Population Study</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>HELLEVIK, Alf Inge ; ASVOLD, Bjørn Olav ; BJØRO, Trine ; ROMUNDSTAD, Pal R ; NILSEN, Tom Ivar L ; VATTEN, Lars J</creator><creatorcontrib>HELLEVIK, Alf Inge ; ASVOLD, Bjørn Olav ; BJØRO, Trine ; ROMUNDSTAD, Pal R ; NILSEN, Tom Ivar L ; VATTEN, Lars J</creatorcontrib><description>Background: It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical
power have investigated this question, and the results have not been consistent.
Methods: In a prospective study of 29,691 people (19,710 women and 9,981 men) without previously known thyroid disease, thyrotropin
was measured at baseline, and cancer incidence was recorded during 9 years of follow-up. Using Cox regression analysis, we
studied the associations (hazard ratios) of thyrotropin categories with total cancer risk, and specifically, with risk of
lung, colon, prostate, and breast cancer adjusted for age, sex, and smoking status.
Results: Low thyrotropin levels (<0.50 mU/L) were associated with increased cancer risk [adjusted hazard ratio (HR), 1.34;
95% confidence interval (CI), 1.06-1.69] compared with the euthyroid reference group. The higher risk was driven by lung cancer
(adjusted HR, 2.34; 95% CI, 1.24-4.40) and prostate cancer (adjusted HR, 1.97; 95% CI, 1.04-3.76). After excluding the first
2 years of follow-up, the associations were strengthened to 2.91 (1.49-5.70) for lung cancer and 2.60 (1.36-4.99) for prostate
cancer.
Conclusion: Thyrotropin levels suggestive of hyperthyroid function are associated with increased cancer risk, and specifically,
with increased risk of lung and prostate cancer, whereas hypothyroid function does not seem to be associated with cancer risk.
(Cancer Epidemiol Biomarkers Prev 2009;18(2):570–4)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-08-0911</identifier><identifier>PMID: 19155436</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast Neoplasms - blood ; Breast Neoplasms - epidemiology ; cancer risk ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - epidemiology ; Endocrinopathies ; epidemiology ; Female ; Humans ; Incidence ; Lung Neoplasms - blood ; Lung Neoplasms - epidemiology ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; Norway - epidemiology ; Prospective Studies ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - epidemiology ; Risk Factors ; thyroid function ; Thyroid Function Tests ; Thyroid. Thyroid axis (diseases) ; thyrotropin ; Thyrotropin - blood ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2009-02, Vol.18 (2), p.570-574</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-51194ebdab53991ba75f149df2183f01c9dd616eb1a51bde83ab648418906acd3</citedby><cites>FETCH-LOGICAL-c416t-51194ebdab53991ba75f149df2183f01c9dd616eb1a51bde83ab648418906acd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21261720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19155436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HELLEVIK, Alf Inge</creatorcontrib><creatorcontrib>ASVOLD, Bjørn Olav</creatorcontrib><creatorcontrib>BJØRO, Trine</creatorcontrib><creatorcontrib>ROMUNDSTAD, Pal R</creatorcontrib><creatorcontrib>NILSEN, Tom Ivar L</creatorcontrib><creatorcontrib>VATTEN, Lars J</creatorcontrib><title>Thyroid Function and Cancer Risk: A Prospective Population Study</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical
power have investigated this question, and the results have not been consistent.
Methods: In a prospective study of 29,691 people (19,710 women and 9,981 men) without previously known thyroid disease, thyrotropin
was measured at baseline, and cancer incidence was recorded during 9 years of follow-up. Using Cox regression analysis, we
studied the associations (hazard ratios) of thyrotropin categories with total cancer risk, and specifically, with risk of
lung, colon, prostate, and breast cancer adjusted for age, sex, and smoking status.
Results: Low thyrotropin levels (<0.50 mU/L) were associated with increased cancer risk [adjusted hazard ratio (HR), 1.34;
95% confidence interval (CI), 1.06-1.69] compared with the euthyroid reference group. The higher risk was driven by lung cancer
(adjusted HR, 2.34; 95% CI, 1.24-4.40) and prostate cancer (adjusted HR, 1.97; 95% CI, 1.04-3.76). After excluding the first
2 years of follow-up, the associations were strengthened to 2.91 (1.49-5.70) for lung cancer and 2.60 (1.36-4.99) for prostate
cancer.
Conclusion: Thyrotropin levels suggestive of hyperthyroid function are associated with increased cancer risk, and specifically,
with increased risk of lung and prostate cancer, whereas hypothyroid function does not seem to be associated with cancer risk.
(Cancer Epidemiol Biomarkers Prev 2009;18(2):570–4)</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - epidemiology</subject><subject>cancer risk</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Endocrinopathies</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norway - epidemiology</subject><subject>Prospective Studies</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Risk Factors</subject><subject>thyroid function</subject><subject>Thyroid Function Tests</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>thyrotropin</subject><subject>Thyrotropin - blood</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0F1PwyAUgGFiNDqnP0HTG_Wqyml7KHjlsjg1WeLixzWhQF21ayesmv172Yd6BQnPAfIScgL0EgD5FVDEWAiGl7eTh5jymAqAHdIDTHmc54i7Yf9rDsih9--U0lwg7pMDEICYpaxHbl6mS9dWJhp1jV5UbROpxkRD1WjroqfKf1xHg2jiWj-34fjLRpN23tVqLZ8XnVkekb1S1d4eb9c-eR3dvgzv4_Hj3cNwMI51BmwRI4DIbGFUgakQUKgcS8iEKRPgaUlBC2MYMFuAQiiM5akqWMYz4IIypU3aJ-ebe-eu_eysX8hZ5bWta9XYtvOSMUEFy_IAcQN1-LV3tpRzV82UW0qgcpVOrrLIVRYZ0knK5SpdmDvdPtAVM2v-p7atAjjbAuW1qksXIlX-zyWQMMgTGtzFxk2rt-l35azU65zOequcnkrgMpGY0_QHHYeEAQ</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>HELLEVIK, Alf Inge</creator><creator>ASVOLD, Bjørn Olav</creator><creator>BJØRO, Trine</creator><creator>ROMUNDSTAD, Pal R</creator><creator>NILSEN, Tom Ivar L</creator><creator>VATTEN, Lars J</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Thyroid Function and Cancer Risk: A Prospective Population Study</title><author>HELLEVIK, Alf Inge ; ASVOLD, Bjørn Olav ; BJØRO, Trine ; ROMUNDSTAD, Pal R ; NILSEN, Tom Ivar L ; VATTEN, Lars J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-51194ebdab53991ba75f149df2183f01c9dd616eb1a51bde83ab648418906acd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - epidemiology</topic><topic>cancer risk</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Endocrinopathies</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Norway - epidemiology</topic><topic>Prospective Studies</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Risk Factors</topic><topic>thyroid function</topic><topic>Thyroid Function Tests</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>thyrotropin</topic><topic>Thyrotropin - blood</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HELLEVIK, Alf Inge</creatorcontrib><creatorcontrib>ASVOLD, Bjørn Olav</creatorcontrib><creatorcontrib>BJØRO, Trine</creatorcontrib><creatorcontrib>ROMUNDSTAD, Pal R</creatorcontrib><creatorcontrib>NILSEN, Tom Ivar L</creatorcontrib><creatorcontrib>VATTEN, Lars J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HELLEVIK, Alf Inge</au><au>ASVOLD, Bjørn Olav</au><au>BJØRO, Trine</au><au>ROMUNDSTAD, Pal R</au><au>NILSEN, Tom Ivar L</au><au>VATTEN, Lars J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid Function and Cancer Risk: A Prospective Population Study</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>18</volume><issue>2</issue><spage>570</spage><epage>574</epage><pages>570-574</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Background: It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical
power have investigated this question, and the results have not been consistent.
Methods: In a prospective study of 29,691 people (19,710 women and 9,981 men) without previously known thyroid disease, thyrotropin
was measured at baseline, and cancer incidence was recorded during 9 years of follow-up. Using Cox regression analysis, we
studied the associations (hazard ratios) of thyrotropin categories with total cancer risk, and specifically, with risk of
lung, colon, prostate, and breast cancer adjusted for age, sex, and smoking status.
Results: Low thyrotropin levels (<0.50 mU/L) were associated with increased cancer risk [adjusted hazard ratio (HR), 1.34;
95% confidence interval (CI), 1.06-1.69] compared with the euthyroid reference group. The higher risk was driven by lung cancer
(adjusted HR, 2.34; 95% CI, 1.24-4.40) and prostate cancer (adjusted HR, 1.97; 95% CI, 1.04-3.76). After excluding the first
2 years of follow-up, the associations were strengthened to 2.91 (1.49-5.70) for lung cancer and 2.60 (1.36-4.99) for prostate
cancer.
Conclusion: Thyrotropin levels suggestive of hyperthyroid function are associated with increased cancer risk, and specifically,
with increased risk of lung and prostate cancer, whereas hypothyroid function does not seem to be associated with cancer risk.
(Cancer Epidemiol Biomarkers Prev 2009;18(2):570–4)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19155436</pmid><doi>10.1158/1055-9965.EPI-08-0911</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - epidemiology cancer risk Colorectal Neoplasms - blood Colorectal Neoplasms - epidemiology Endocrinopathies epidemiology Female Humans Incidence Lung Neoplasms - blood Lung Neoplasms - epidemiology Male Malignant tumors Medical sciences Middle Aged Norway - epidemiology Prospective Studies Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Risk Factors thyroid function Thyroid Function Tests Thyroid. Thyroid axis (diseases) thyrotropin Thyrotropin - blood Tumors |
| title | Thyroid Function and Cancer Risk: A Prospective Population Study |
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