SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors

The Y chromosome gene Sry encodes a transcription factor required to initiate testis development. The related autosomal gene Sox9 is up-regulated shortly after the onset of Sry transcription and is thought essential for the differentiation of Sertoli cells. The lineage that gives rise to Sertoli cel...

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Veröffentlicht in:	Developmental biology 2004-10, Vol.274 (2), p.271-279
Hauptverfasser:	Sekido, Ryohei, Bar, Isabelle, Narváez, Véronica, Penny, Graeme, Lovell-Badge, Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Cell Lineage DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene Expression Regulation, Developmental Genes, Reporter Gonads - cytology Gonads - growth & development Gonads - metabolism High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Humans Male Mice Mice, Transgenic Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype Promoter Regions, Genetic Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sertoli cell Sertoli Cells - cytology Sertoli Cells - physiology Sex Determination Processes Sex Differentiation - physiology Sex-Determining Region Y Protein Sox9 SOX9 Transcription Factor Sry Testis development Transcription Factors - genetics Transcription Factors - metabolism Transgenes Transgenic mice Up-Regulation Y Chromosome
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