Discovery of genes implicated in placode formation
The peripheral nervous system of the head is derived from cranial ectodermal placodes and neural crest cells. Placodes arise from thickenings in the cranial ectoderm that invaginate or ingress to form sensory ganglia and the paired sense organs. We have combined embryological techniques with array t...
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| Veröffentlicht in: | Developmental biology 2004-10, Vol.274 (2), p.462-477 |
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| creator | McCabe, Kathryn L. Manzo, Andrea Gammill, Laura S. Bronner-Fraser, Marianne |
| description | The peripheral nervous system of the head is derived from cranial ectodermal placodes and neural crest cells. Placodes arise from thickenings in the cranial ectoderm that invaginate or ingress to form sensory ganglia and the paired sense organs. We have combined embryological techniques with array technology to identify genes that are expressed as a consequence of placode induction. As a secondary screen, we used whole mount in situ hybridization to determine the expression of candidate genes in various placodal domains. The results reveal 52 genes that are found in one or more placodes, including the olfactory, trigeminal, and otic placodes. Expression of some of these genes is retained in placodal derivatives. Furthermore, several genes are common to both neural crest and ectodermal placodes. This study presents the first array of candidate genes implicated in placode development, providing numerous new molecular markers for various stages of placode formation. Importantly, the results uncover previously unknown commonalities in genes expressed by multiple placodes and shared properties between placodes and other migratory cells, like neural crest cells. |
| doi_str_mv | 10.1016/j.ydbio.2004.07.012 |
| format | Article |
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Placodes arise from thickenings in the cranial ectoderm that invaginate or ingress to form sensory ganglia and the paired sense organs. We have combined embryological techniques with array technology to identify genes that are expressed as a consequence of placode induction. As a secondary screen, we used whole mount in situ hybridization to determine the expression of candidate genes in various placodal domains. The results reveal 52 genes that are found in one or more placodes, including the olfactory, trigeminal, and otic placodes. Expression of some of these genes is retained in placodal derivatives. Furthermore, several genes are common to both neural crest and ectodermal placodes. This study presents the first array of candidate genes implicated in placode development, providing numerous new molecular markers for various stages of placode formation. 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Placodes arise from thickenings in the cranial ectoderm that invaginate or ingress to form sensory ganglia and the paired sense organs. We have combined embryological techniques with array technology to identify genes that are expressed as a consequence of placode induction. As a secondary screen, we used whole mount in situ hybridization to determine the expression of candidate genes in various placodal domains. The results reveal 52 genes that are found in one or more placodes, including the olfactory, trigeminal, and otic placodes. Expression of some of these genes is retained in placodal derivatives. Furthermore, several genes are common to both neural crest and ectodermal placodes. This study presents the first array of candidate genes implicated in placode development, providing numerous new molecular markers for various stages of placode formation. Importantly, the results uncover previously unknown commonalities in genes expressed by multiple placodes and shared properties between placodes and other migratory cells, like neural crest cells.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Chicken</subject><subject>Chickens</subject><subject>Ectoderm - cytology</subject><subject>Ectoderm - physiology</subject><subject>Embryonic Structures - physiology</subject><subject>Epibranchial</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Developmental</subject><subject>In Situ Hybridization</subject><subject>Induction</subject><subject>Neural crest</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - physiology</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Olfactory</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Otic</subject><subject>Peripheral Nervous System - anatomy & histology</subject><subject>Peripheral Nervous System - embryology</subject><subject>Peripheral Nervous System - physiology</subject><subject>Placodes</subject><subject>Quail</subject><subject>Space life sciences</subject><subject>Subtraction</subject><subject>Trigeminal</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlZ_gSB78rbr5GOz24MHqZ9Q8KLgLaTJRFJ2NzXZFvrv3dqCNz0NDM_7zvAQckmhoEDlzbLY2oUPBQMQBVQFUHZExhSmZV5K8XFMxjCscipBjshZSksA4HXNT8mIlrwuacXGhN37ZMIG4zYLLvvEDlPm21Xjje7RZr7LVo02wWLmQmx170N3Tk6cbhJeHOaEvD8-vM2e8_nr08vsbp4bwWmfG0epAOEkdcJIrB1HYK40jgvU1iHTVc0Ft0xri0yUQmgJUDqGQvLSOj4h1_veVQxfa0y9aodfsWl0h2GdlJRTqECwf0EGspIU-ADyPWhiSCmiU6voWx23ioLaOVVL9eNU7ZwqqNQgcEhdHerXixbtb-YgcQBu9wAONjYeo0rGY2fQ-oimVzb4Pw98A4ntiD8</recordid><startdate>20041015</startdate><enddate>20041015</enddate><creator>McCabe, Kathryn L.</creator><creator>Manzo, Andrea</creator><creator>Gammill, Laura S.</creator><creator>Bronner-Fraser, Marianne</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20041015</creationdate><title>Discovery of genes implicated in placode formation</title><author>McCabe, Kathryn L. ; Manzo, Andrea ; Gammill, Laura S. ; Bronner-Fraser, Marianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-cf11404f61f4c6e8f3e02f5cf34eadfe2a78343d2aade24544a6005f2e4635df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Chicken</topic><topic>Chickens</topic><topic>Ectoderm - cytology</topic><topic>Ectoderm - physiology</topic><topic>Embryonic Structures - physiology</topic><topic>Epibranchial</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Developmental</topic><topic>In Situ Hybridization</topic><topic>Induction</topic><topic>Neural crest</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - physiology</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Olfactory</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Otic</topic><topic>Peripheral Nervous System - anatomy & histology</topic><topic>Peripheral Nervous System - embryology</topic><topic>Peripheral Nervous System - physiology</topic><topic>Placodes</topic><topic>Quail</topic><topic>Space life sciences</topic><topic>Subtraction</topic><topic>Trigeminal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCabe, Kathryn L.</creatorcontrib><creatorcontrib>Manzo, Andrea</creatorcontrib><creatorcontrib>Gammill, Laura S.</creatorcontrib><creatorcontrib>Bronner-Fraser, Marianne</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCabe, Kathryn L.</au><au>Manzo, Andrea</au><au>Gammill, Laura S.</au><au>Bronner-Fraser, Marianne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of genes implicated in placode formation</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>2004-10-15</date><risdate>2004</risdate><volume>274</volume><issue>2</issue><spage>462</spage><epage>477</epage><pages>462-477</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>The peripheral nervous system of the head is derived from cranial ectodermal placodes and neural crest cells. Placodes arise from thickenings in the cranial ectoderm that invaginate or ingress to form sensory ganglia and the paired sense organs. We have combined embryological techniques with array technology to identify genes that are expressed as a consequence of placode induction. As a secondary screen, we used whole mount in situ hybridization to determine the expression of candidate genes in various placodal domains. The results reveal 52 genes that are found in one or more placodes, including the olfactory, trigeminal, and otic placodes. Expression of some of these genes is retained in placodal derivatives. Furthermore, several genes are common to both neural crest and ectodermal placodes. This study presents the first array of candidate genes implicated in placode development, providing numerous new molecular markers for various stages of placode formation. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biomarkers Chicken Chickens Ectoderm - cytology Ectoderm - physiology Embryonic Structures - physiology Epibranchial Gene Expression Profiling Gene Expression Regulation, Developmental In Situ Hybridization Induction Neural crest Neural Crest - cytology Neural Crest - physiology Neurons - cytology Neurons - physiology Olfactory Oligonucleotide Array Sequence Analysis Otic Peripheral Nervous System - anatomy & histology Peripheral Nervous System - embryology Peripheral Nervous System - physiology Placodes Quail Space life sciences Subtraction Trigeminal |
| title | Discovery of genes implicated in placode formation |
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