Noncovalent Multivalent Assembly of Jun Peptides on a Leucine Zipper Dendrimer Displaying Fos Peptides
The synthesis and characterization of a new leucine-zipper dendrimer (LZD) is reported that displays four copies of the peptide corresponding to the coiled-coiled dimerization domain of Fos. Circular dichroism spectroscopy, fluorescence titration, and sedimentation equilibrium experiments demonstrat...
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| Veröffentlicht in: | Organic letters 2004-09, Vol.6 (20), p.3561-3564 |
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| container_title | Organic letters |
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| creator | Zhou, Min Ghosh, Indraneel |
| description | The synthesis and characterization of a new leucine-zipper dendrimer (LZD) is reported that displays four copies of the peptide corresponding to the coiled-coiled dimerization domain of Fos. Circular dichroism spectroscopy, fluorescence titration, and sedimentation equilibrium experiments demonstrate that Fos-LZD can noncovalently assemble four copies of the peptide corresponding to the coiled-coil domain of Jun. This work provides the basis for the future construction of noncovalently assembled multivalent protein assemblies displaying any protein of interest. |
| doi_str_mv | 10.1021/ol0485262 |
| format | Article |
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Circular dichroism spectroscopy, fluorescence titration, and sedimentation equilibrium experiments demonstrate that Fos-LZD can noncovalently assemble four copies of the peptide corresponding to the coiled-coil domain of Jun. This work provides the basis for the future construction of noncovalently assembled multivalent protein assemblies displaying any protein of interest.</description><identifier>ISSN: 1523-7060</identifier><identifier>EISSN: 1523-7052</identifier><identifier>DOI: 10.1021/ol0485262</identifier><identifier>PMID: 15387548</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Amino Acid Sequence ; Circular Dichroism ; Leucine Zippers ; Molecular Sequence Data ; Molecular Structure ; Peptides - chemistry ; Protein Conformation ; Proto-Oncogene Proteins c-fos - chemical synthesis ; Proto-Oncogene Proteins c-jun - chemical synthesis</subject><ispartof>Organic letters, 2004-09, Vol.6 (20), p.3561-3564</ispartof><rights>Copyright © 2004 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a377t-5b1ec5db019085bd676f1752f005fd61099e221d5ea10e4d114abbb84fd86cf3</citedby><cites>FETCH-LOGICAL-a377t-5b1ec5db019085bd676f1752f005fd61099e221d5ea10e4d114abbb84fd86cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ol0485262$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ol0485262$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15387548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Ghosh, Indraneel</creatorcontrib><title>Noncovalent Multivalent Assembly of Jun Peptides on a Leucine Zipper Dendrimer Displaying Fos Peptides</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>The synthesis and characterization of a new leucine-zipper dendrimer (LZD) is reported that displays four copies of the peptide corresponding to the coiled-coiled dimerization domain of Fos. Circular dichroism spectroscopy, fluorescence titration, and sedimentation equilibrium experiments demonstrate that Fos-LZD can noncovalently assemble four copies of the peptide corresponding to the coiled-coil domain of Jun. This work provides the basis for the future construction of noncovalently assembled multivalent protein assemblies displaying any protein of interest.</description><subject>Amino Acid Sequence</subject><subject>Circular Dichroism</subject><subject>Leucine Zippers</subject><subject>Molecular Sequence Data</subject><subject>Molecular Structure</subject><subject>Peptides - chemistry</subject><subject>Protein Conformation</subject><subject>Proto-Oncogene Proteins c-fos - chemical synthesis</subject><subject>Proto-Oncogene Proteins c-jun - chemical synthesis</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAURS0EolAY-APIC0gMATuJnWSsCuVD5WPoxBLZ8TNy5dghTpD670nVqCxMvrLOO3rvInRByS0lMb3zlqQ5i3l8gE4oi5MoIyw-3GdOJug0hDUhdPgpjtGEsiTPWJqfIP3mXeV_hAXX4dfedmbMsxCglnaDvcYvvcMf0HRGQcDeYYGX0FfGAf40TQMtvgenWlNvkwmNFRvjvvDCh_3UGTrSwgY4H98pWi0eVvOnaPn--DyfLSORZFkXMUmhYkoSWpCcScUzrmnGYk0I04pTUhQQx1QxEJRAqihNhZQyT7XKeaWTKbreaZvWf_cQurI2oQJrhQPfh5LzggxOMoA3O7BqfQgt6LIZ9hftpqSk3HZa7jsd2MtR2ssa1B85ljgAVztAVKFc-751w4n_iH4BTKB92g</recordid><startdate>20040930</startdate><enddate>20040930</enddate><creator>Zhou, Min</creator><creator>Ghosh, Indraneel</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040930</creationdate><title>Noncovalent Multivalent Assembly of Jun Peptides on a Leucine Zipper Dendrimer Displaying Fos Peptides</title><author>Zhou, Min ; Ghosh, Indraneel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a377t-5b1ec5db019085bd676f1752f005fd61099e221d5ea10e4d114abbb84fd86cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence</topic><topic>Circular Dichroism</topic><topic>Leucine Zippers</topic><topic>Molecular Sequence Data</topic><topic>Molecular Structure</topic><topic>Peptides - chemistry</topic><topic>Protein Conformation</topic><topic>Proto-Oncogene Proteins c-fos - chemical synthesis</topic><topic>Proto-Oncogene Proteins c-jun - chemical synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Ghosh, Indraneel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Min</au><au>Ghosh, Indraneel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noncovalent Multivalent Assembly of Jun Peptides on a Leucine Zipper Dendrimer Displaying Fos Peptides</atitle><jtitle>Organic letters</jtitle><addtitle>Org. 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| ispartof | Organic letters, 2004-09, Vol.6 (20), p.3561-3564 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Amino Acid Sequence Circular Dichroism Leucine Zippers Molecular Sequence Data Molecular Structure Peptides - chemistry Protein Conformation Proto-Oncogene Proteins c-fos - chemical synthesis Proto-Oncogene Proteins c-jun - chemical synthesis |
| title | Noncovalent Multivalent Assembly of Jun Peptides on a Leucine Zipper Dendrimer Displaying Fos Peptides |
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