Restoration of T-box–containing protein expressed in T cells protects against allergen-induced asthma

Background A TH 1-specific transcription factor, T-box–containing protein expressed in T cells (T-bet), controls the production of both TH 1 and TH 2 cytokines in TH cell differentiation by means of distinct mechanisms. T-bet–deficient mice overproduce TH 2 cytokines and have spontaneous airway infl...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2009-02, Vol.123 (2), p.479-485.e6
Hauptverfasser:	Park, Jung Won, MD, Min, Hyun Jung, MS, Sohn, Jung Ho, BS, Kim, Joo Young, PhD, Hong, Jeong Ho, PhD, Sigrist, Kirsten S., BS, Glimcher, Laurie H., MD, PhD, Hwang, Eun Sook, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	airway hyperresponsiveness Allergens - immunology Allergy and Immunology Animals asthma Asthma - immunology Asthma - metabolism Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology Cytokines - drug effects Cytokines - immunology Cytokines - metabolism Disease Models, Animal Doxycycline - pharmacology Eosinophilia - immunology Eosinophilia - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Goblet Cells - immunology Goblet Cells - pathology Immune system Immunoglobulin E - blood Lymphocytes Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic OVA Ovalbumin - immunology Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sucrose T cell T-bet T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - metabolism transgenic mice
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