Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media
Localized atomic force microscopy (AFM) force analysis on poly(lactic acid) (PLA) and poly(lactic acid)/everolimus coated stents has been performed under ambient conditions. Similar Young's modulus were derived from both PLA and PLA/everolimus stent surface, namely 2.25 ± 0.46 and 2.04 ± 0.39 G...
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| Veröffentlicht in: | European journal of pharmaceutical sciences 2009-03, Vol.36 (4), p.493-501 |
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| creator | Wu, Ming Kleiner, Lothar Tang, Fuh-Wei Hossainy, Syed Davies, Martyn C. Roberts, Clive J. |
| description | Localized atomic force microscopy (AFM) force analysis on poly(lactic acid) (PLA) and poly(lactic acid)/everolimus coated stents has been performed under ambient conditions. Similar Young's modulus were derived from both PLA and PLA/everolimus stent surface, namely 2.25
±
0.46 and 2.04
±
0.39
GPa, respectively, indicating that the drug, everolimus does not significantly effect the mechanical properties of PLA up to a 1:1 (w/w) drug loading. Temperature controlled force measurements on PLA only coated stents in air and in a 1% Triton surfactant solution allowed the glass transition temperature (
T
g) of the polymer to be determined. A significant drop of the Young's modulus in solution was observed at 36
°C, suggests that
in vivo the
T
g of the polymer is below body temperature. The possible consequences on drug release and the mechanisms by which this may occur are considered. |
| doi_str_mv | 10.1016/j.ejps.2008.12.001 |
| format | Article |
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±
0.46 and 2.04
±
0.39
GPa, respectively, indicating that the drug, everolimus does not significantly effect the mechanical properties of PLA up to a 1:1 (w/w) drug loading. Temperature controlled force measurements on PLA only coated stents in air and in a 1% Triton surfactant solution allowed the glass transition temperature (
T
g) of the polymer to be determined. A significant drop of the Young's modulus in solution was observed at 36
°C, suggests that
in vivo the
T
g of the polymer is below body temperature. The possible consequences on drug release and the mechanisms by which this may occur are considered.</description><identifier>ISSN: 0928-0987</identifier><identifier>EISSN: 1879-0720</identifier><identifier>DOI: 10.1016/j.ejps.2008.12.001</identifier><identifier>PMID: 19111614</identifier><language>eng</language><publisher>Kindlington: Elsevier B.V</publisher><subject>AFM ; Biological and medical sciences ; Everolimus ; General pharmacology ; Glass ; Glass transition temperature ; Hot Temperature ; Lactic Acid - chemistry ; Medical sciences ; Microscopy, Atomic Force ; Nano-indentation ; Nanotechnology ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyesters ; Polylactic acid ; Polymers - chemistry ; Sirolimus - analogs & derivatives ; Sirolimus - chemistry ; Solubility ; Stents</subject><ispartof>European journal of pharmaceutical sciences, 2009-03, Vol.36 (4), p.493-501</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-c88ab9c835e5793d50b80281d27acfe8df51e8fbdc515d754f281b47c84307553</citedby><cites>FETCH-LOGICAL-c384t-c88ab9c835e5793d50b80281d27acfe8df51e8fbdc515d754f281b47c84307553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928098708004843$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21252676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19111614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Kleiner, Lothar</creatorcontrib><creatorcontrib>Tang, Fuh-Wei</creatorcontrib><creatorcontrib>Hossainy, Syed</creatorcontrib><creatorcontrib>Davies, Martyn C.</creatorcontrib><creatorcontrib>Roberts, Clive J.</creatorcontrib><title>Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media</title><title>European journal of pharmaceutical sciences</title><addtitle>Eur J Pharm Sci</addtitle><description>Localized atomic force microscopy (AFM) force analysis on poly(lactic acid) (PLA) and poly(lactic acid)/everolimus coated stents has been performed under ambient conditions. Similar Young's modulus were derived from both PLA and PLA/everolimus stent surface, namely 2.25
±
0.46 and 2.04
±
0.39
GPa, respectively, indicating that the drug, everolimus does not significantly effect the mechanical properties of PLA up to a 1:1 (w/w) drug loading. Temperature controlled force measurements on PLA only coated stents in air and in a 1% Triton surfactant solution allowed the glass transition temperature (
T
g) of the polymer to be determined. A significant drop of the Young's modulus in solution was observed at 36
°C, suggests that
in vivo the
T
g of the polymer is below body temperature. The possible consequences on drug release and the mechanisms by which this may occur are considered.</description><subject>AFM</subject><subject>Biological and medical sciences</subject><subject>Everolimus</subject><subject>General pharmacology</subject><subject>Glass</subject><subject>Glass transition temperature</subject><subject>Hot Temperature</subject><subject>Lactic Acid - chemistry</subject><subject>Medical sciences</subject><subject>Microscopy, Atomic Force</subject><subject>Nano-indentation</subject><subject>Nanotechnology</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyesters</subject><subject>Polylactic acid</subject><subject>Polymers - chemistry</subject><subject>Sirolimus - analogs & derivatives</subject><subject>Sirolimus - chemistry</subject><subject>Solubility</subject><subject>Stents</subject><issn>0928-0987</issn><issn>1879-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPCC7BA3oDKIqntxIkjdYMq_qQKNrC2HPuGepTYg69TqQ_Du-J0RrBj5Sv7O0fX5xDyirOaM95d7WvYH7AWjKmai5ox_oTsuOqHivWCPSU7NghVsUH1Z-Qccc8Y61TPnpMzPnDOO97uyO-vJkS0Zga6gL0zwZe5jAbXBAuETB1kSIsPJvsYaJxovgP6czaINCcT0D_eZ1gOkEwuqo05xPnhcjY2e0uN9e7dFdxDirNfVqQ2mgyOYi72SH2gxidqgqPOI8Z5fTRcwHnzgjybzIzw8nRekB8fP3y_-Vzdfvv05eb9bWUb1ebKKmXGwapGguyHxkk2KiYUd6I3dgLlJslBTaOzkkvXy3Yqj2PbW9U2rJeyuSBvj76HFH-tgFkvHi3MswkQV9RdN7BWNG0BxRG0KSImmPQh-cWkB82Z3krRe72VordSNBe6lFJEr0_u61i-9U9yaqEAb06A2aqYSqzW419OcCFF13eFuz5yULK495A0Wg_BlqgS2Kxd9P_b4w-ova7O</recordid><startdate>20090302</startdate><enddate>20090302</enddate><creator>Wu, Ming</creator><creator>Kleiner, Lothar</creator><creator>Tang, Fuh-Wei</creator><creator>Hossainy, Syed</creator><creator>Davies, Martyn C.</creator><creator>Roberts, Clive J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090302</creationdate><title>Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media</title><author>Wu, Ming ; Kleiner, Lothar ; Tang, Fuh-Wei ; Hossainy, Syed ; Davies, Martyn C. ; Roberts, Clive J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-c88ab9c835e5793d50b80281d27acfe8df51e8fbdc515d754f281b47c84307553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>AFM</topic><topic>Biological and medical sciences</topic><topic>Everolimus</topic><topic>General pharmacology</topic><topic>Glass</topic><topic>Glass transition temperature</topic><topic>Hot Temperature</topic><topic>Lactic Acid - chemistry</topic><topic>Medical sciences</topic><topic>Microscopy, Atomic Force</topic><topic>Nano-indentation</topic><topic>Nanotechnology</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyesters</topic><topic>Polylactic acid</topic><topic>Polymers - chemistry</topic><topic>Sirolimus - analogs & derivatives</topic><topic>Sirolimus - chemistry</topic><topic>Solubility</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Kleiner, Lothar</creatorcontrib><creatorcontrib>Tang, Fuh-Wei</creatorcontrib><creatorcontrib>Hossainy, Syed</creatorcontrib><creatorcontrib>Davies, Martyn C.</creatorcontrib><creatorcontrib>Roberts, Clive J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Ming</au><au>Kleiner, Lothar</au><au>Tang, Fuh-Wei</au><au>Hossainy, Syed</au><au>Davies, Martyn C.</au><au>Roberts, Clive J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media</atitle><jtitle>European journal of pharmaceutical sciences</jtitle><addtitle>Eur J Pharm Sci</addtitle><date>2009-03-02</date><risdate>2009</risdate><volume>36</volume><issue>4</issue><spage>493</spage><epage>501</epage><pages>493-501</pages><issn>0928-0987</issn><eissn>1879-0720</eissn><abstract>Localized atomic force microscopy (AFM) force analysis on poly(lactic acid) (PLA) and poly(lactic acid)/everolimus coated stents has been performed under ambient conditions. Similar Young's modulus were derived from both PLA and PLA/everolimus stent surface, namely 2.25
±
0.46 and 2.04
±
0.39
GPa, respectively, indicating that the drug, everolimus does not significantly effect the mechanical properties of PLA up to a 1:1 (w/w) drug loading. Temperature controlled force measurements on PLA only coated stents in air and in a 1% Triton surfactant solution allowed the glass transition temperature (
T
g) of the polymer to be determined. A significant drop of the Young's modulus in solution was observed at 36
°C, suggests that
in vivo the
T
g of the polymer is below body temperature. The possible consequences on drug release and the mechanisms by which this may occur are considered.</abstract><cop>Kindlington</cop><pub>Elsevier B.V</pub><pmid>19111614</pmid><doi>10.1016/j.ejps.2008.12.001</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0928-0987 |
| ispartof | European journal of pharmaceutical sciences, 2009-03, Vol.36 (4), p.493-501 |
| issn | 0928-0987 1879-0720 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | AFM Biological and medical sciences Everolimus General pharmacology Glass Glass transition temperature Hot Temperature Lactic Acid - chemistry Medical sciences Microscopy, Atomic Force Nano-indentation Nanotechnology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters Polylactic acid Polymers - chemistry Sirolimus - analogs & derivatives Sirolimus - chemistry Solubility Stents |
| title | Nanoscale mechanical measurement determination of the glass transition temperature of poly(lactic acid)/everolimus coated stents in air and dissolution media |
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