PKC-interacting proteins: from function to pharmacology
Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins...
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| Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2004-10, Vol.25 (10), p.528-535 |
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| container_end_page | 535 |
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| container_title | Trends in pharmacological sciences (Regular ed.) |
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| creator | Poole, Alastair W. Pula, Giordano Hers, Ingeborg Crosby, David Jones, Matthew L. |
| description | Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development. |
| doi_str_mv | 10.1016/j.tips.2004.08.006 |
| format | Article |
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| ispartof | Trends in pharmacological sciences (Regular ed.), 2004-10, Vol.25 (10), p.528-535 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Carrier Proteins - chemistry Carrier Proteins - metabolism Drug Delivery Systems - methods Humans Isoenzymes - chemistry Isoenzymes - metabolism Protein Binding - drug effects Protein Binding - physiology Protein Interaction Mapping - methods Protein Kinase C - chemistry Protein Kinase C - metabolism |
| title | PKC-interacting proteins: from function to pharmacology |
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