Dose‐dependent Immunomodulatory Effects of Acetylsalicylic Acid and Indomethacin in Human Whole Blood: Potential Role of Cyclooxygenase‐2 Inhibition

The aim of the study was to characterize the in vitro effect of non‐steroidal anti‐inflammatory drugs (NSAIDs) on the production of pro‐inflammatory cytokines in a human whole blood assay. Whole blood samples were pre‐incubated with acetylsalicylic acid, indomethacin, selective cyclooxygenase (COX)‐...

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Veröffentlicht in:	Scandinavian journal of immunology 2004-10, Vol.60 (4), p.412-420
Hauptverfasser:	Härtel, C., Von Puttkamer, J., Gallner, F., Strunk, T., Schultz, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adult Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Aspirin - administration & dosage Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - administration & dosage Cytokines - biosynthesis Dinoprostone - pharmacology Dose-Response Relationship, Drug Humans In Vitro Techniques Indomethacin - administration & dosage Inflammation Mediators - metabolism Interleukin-6 - biosynthesis Isoenzymes - antagonists & inhibitors Lipopolysaccharides - pharmacology Membrane Proteins Monocytes - drug effects Monocytes - immunology Prostaglandin-Endoperoxide Synthases Tumor Necrosis Factor-alpha - biosynthesis
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