Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor γ synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells

Abstract Although inhibition of cyclooxygenase-2 (COX-2) or activation of peroxisome proliferators-activated receptor γ (PPAR-γ) leads to growth inhibition in malignancies, the synergistic anti-tumor effects of combination of COX-2 inhibitor (NS-398) and PPAR-γ agonist (rosiglitazone) on the human p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2009-03, Vol.275 (2), p.247-255
Hauptverfasser:	Sun, Wei-Hao, Chen, Guo-Sheng, Ou, Xi-Long, Yang, Ye, Luo, Cheng, Zhang, Yuan, Shao, Yun, Xu, Hai-Chen, Xiao, Bin, Xue, Yi-Ping, Zhou, Su-Ming, Zhao, Qin-Shi, Ding, Guo-Xian
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Base Sequence Cell Line, Tumor Cell Proliferation - drug effects Cyclooxygenase 2 - drug effects Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase-2 DNA Primers Electrophoresis, Polyacrylamide Gel Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Nitrobenzenes - pharmacology Pancreatic cancer Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Peroxisome proliferators-activated receptor γ PPAR gamma - agonists Proliferating Cell Nuclear Antigen - metabolism Proliferation Sulfonamides - pharmacology Thiazolidinediones - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!