Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients
This study was designed to compare growth hormone, cortisol and prolactin responses to physical exercise in depressed patients and healthy comparison subjects. Patients fulfilled the DSM-IV diagnostic criteria for current major depressive disorder; subjective depressive symptoms were rated with Mont...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2004-09, Vol.28 (6), p.1007-1013 |
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| creator | Kiive, Evelyn Maaroos, Jaak Shlik, Jakov Tõru, Innar Harro, Jaanus |
| description | This study was designed to compare growth hormone, cortisol and prolactin responses to physical exercise in depressed patients and healthy comparison subjects. Patients fulfilled the DSM-IV diagnostic criteria for current major depressive disorder; subjective depressive symptoms were rated with Montgomery-Åsberg Depression Rating Scale (MÅDRS) immediately before the experiment. Growth hormone, cortisol and prolactin were measured before and immediately after physiologically stressful bicycle cardiopulmonary exercise test. After exercise, there were three additional hormone measurements, with 30-min intervals. No significant difference was found in baseline growth hormone, cortisol or prolactin levels between patients and the control group. Plasma growth hormone and cortisol levels increased significantly during physical exercise in both patients and controls and returned to baseline in 90 min. There was no significant difference in growth hormone or cortisol responses to physical exercise between the two groups. However, prolactin levels increased only in the depressed patients group during the exercise. We hypothesize that acute exercise may have a stronger effect on serotonin (5-HT) release in depressed patients, which is reflected in increased plasma prolactin concentration. |
| doi_str_mv | 10.1016/j.pnpbp.2004.05.035 |
| format | Article |
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Patients fulfilled the DSM-IV diagnostic criteria for current major depressive disorder; subjective depressive symptoms were rated with Montgomery-Åsberg Depression Rating Scale (MÅDRS) immediately before the experiment. Growth hormone, cortisol and prolactin were measured before and immediately after physiologically stressful bicycle cardiopulmonary exercise test. After exercise, there were three additional hormone measurements, with 30-min intervals. No significant difference was found in baseline growth hormone, cortisol or prolactin levels between patients and the control group. Plasma growth hormone and cortisol levels increased significantly during physical exercise in both patients and controls and returned to baseline in 90 min. There was no significant difference in growth hormone or cortisol responses to physical exercise between the two groups. However, prolactin levels increased only in the depressed patients group during the exercise. We hypothesize that acute exercise may have a stronger effect on serotonin (5-HT) release in depressed patients, which is reflected in increased plasma prolactin concentration.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2004.05.035</identifier><identifier>PMID: 15380861</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Analysis of Variance ; Cortisol ; Depression ; Depressive Disorder - blood ; Exercise - physiology ; Exercise Test - methods ; Growth hormone ; Growth Hormone - blood ; Humans ; Hydrocortisone - blood ; Immunoassay - methods ; Male ; Middle Aged ; MÅDRS ; Physical exercise ; Prolactin ; Prolactin - blood ; Psychiatric Status Rating Scales ; Time Factors</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2004-09, Vol.28 (6), p.1007-1013</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-1c48cc7792d7cc59b32bd5856804fff06f4cf6975d7762f3a085d24922d6ad63</citedby><cites>FETCH-LOGICAL-c452t-1c48cc7792d7cc59b32bd5856804fff06f4cf6975d7762f3a085d24922d6ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2004.05.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15380861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiive, Evelyn</creatorcontrib><creatorcontrib>Maaroos, Jaak</creatorcontrib><creatorcontrib>Shlik, Jakov</creatorcontrib><creatorcontrib>Tõru, Innar</creatorcontrib><creatorcontrib>Harro, Jaanus</creatorcontrib><title>Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>This study was designed to compare growth hormone, cortisol and prolactin responses to physical exercise in depressed patients and healthy comparison subjects. Patients fulfilled the DSM-IV diagnostic criteria for current major depressive disorder; subjective depressive symptoms were rated with Montgomery-Åsberg Depression Rating Scale (MÅDRS) immediately before the experiment. Growth hormone, cortisol and prolactin were measured before and immediately after physiologically stressful bicycle cardiopulmonary exercise test. After exercise, there were three additional hormone measurements, with 30-min intervals. No significant difference was found in baseline growth hormone, cortisol or prolactin levels between patients and the control group. Plasma growth hormone and cortisol levels increased significantly during physical exercise in both patients and controls and returned to baseline in 90 min. There was no significant difference in growth hormone or cortisol responses to physical exercise between the two groups. However, prolactin levels increased only in the depressed patients group during the exercise. We hypothesize that acute exercise may have a stronger effect on serotonin (5-HT) release in depressed patients, which is reflected in increased plasma prolactin concentration.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Cortisol</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Exercise - physiology</subject><subject>Exercise Test - methods</subject><subject>Growth hormone</subject><subject>Growth Hormone - blood</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Immunoassay - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MÅDRS</subject><subject>Physical exercise</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Psychiatric Status Rating Scales</subject><subject>Time Factors</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo7rj6CQTJyZPTVpLOnxY8yKKrsOBl7yGTVNsZejptklndb2_WGfAiSh2qAr_3KtQj5CWDjgFTb_fduqy7teMAfQeyAyEfkQ0z2mx7ztRjsgHeZml6dUGelbIHACZAPCUXTAoDRrENubvO6Ued6JTyIS34hvqUayxppm4JdM1pdr7GhWYsa1oKFloTXaf7Er2bKf7E7GPBd3SK3ybMfxHQNgdc27NgM3Q14lLLc_JkdHPBF-d-SW4_fby9-ry9-Xr95erDzdb3ktct873xXuuBB-29HHaC74I0Uhnox3EENfZ-VIOWQWvFR-HAyMD7gfOgXFDikrw-2bZ_fT9iqfYQi8d5dgumY7FKDSBYq_-BTEujtYYGihPocyol42jXHA8u31sG9iEWu7e_Y7EPsViQtsXSVK_O9sfdAcMfzTmHBrw_AdiOcRcx2-LboTyGmNFXG1L854JfzAGh4g</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Kiive, Evelyn</creator><creator>Maaroos, Jaak</creator><creator>Shlik, Jakov</creator><creator>Tõru, Innar</creator><creator>Harro, Jaanus</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients</title><author>Kiive, Evelyn ; Maaroos, Jaak ; Shlik, Jakov ; Tõru, Innar ; Harro, Jaanus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-1c48cc7792d7cc59b32bd5856804fff06f4cf6975d7762f3a085d24922d6ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Cortisol</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Exercise - physiology</topic><topic>Exercise Test - methods</topic><topic>Growth hormone</topic><topic>Growth Hormone - blood</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Immunoassay - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MÅDRS</topic><topic>Physical exercise</topic><topic>Prolactin</topic><topic>Prolactin - blood</topic><topic>Psychiatric Status Rating Scales</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiive, Evelyn</creatorcontrib><creatorcontrib>Maaroos, Jaak</creatorcontrib><creatorcontrib>Shlik, Jakov</creatorcontrib><creatorcontrib>Tõru, Innar</creatorcontrib><creatorcontrib>Harro, Jaanus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiive, Evelyn</au><au>Maaroos, Jaak</au><au>Shlik, Jakov</au><au>Tõru, Innar</au><au>Harro, Jaanus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>28</volume><issue>6</issue><spage>1007</spage><epage>1013</epage><pages>1007-1013</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><abstract>This study was designed to compare growth hormone, cortisol and prolactin responses to physical exercise in depressed patients and healthy comparison subjects. Patients fulfilled the DSM-IV diagnostic criteria for current major depressive disorder; subjective depressive symptoms were rated with Montgomery-Åsberg Depression Rating Scale (MÅDRS) immediately before the experiment. Growth hormone, cortisol and prolactin were measured before and immediately after physiologically stressful bicycle cardiopulmonary exercise test. After exercise, there were three additional hormone measurements, with 30-min intervals. No significant difference was found in baseline growth hormone, cortisol or prolactin levels between patients and the control group. Plasma growth hormone and cortisol levels increased significantly during physical exercise in both patients and controls and returned to baseline in 90 min. There was no significant difference in growth hormone or cortisol responses to physical exercise between the two groups. However, prolactin levels increased only in the depressed patients group during the exercise. We hypothesize that acute exercise may have a stronger effect on serotonin (5-HT) release in depressed patients, which is reflected in increased plasma prolactin concentration.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>15380861</pmid><doi>10.1016/j.pnpbp.2004.05.035</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0278-5846 |
| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 2004-09, Vol.28 (6), p.1007-1013 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Aged Analysis of Variance Cortisol Depression Depressive Disorder - blood Exercise - physiology Exercise Test - methods Growth hormone Growth Hormone - blood Humans Hydrocortisone - blood Immunoassay - methods Male Middle Aged MÅDRS Physical exercise Prolactin Prolactin - blood Psychiatric Status Rating Scales Time Factors |
| title | Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients |
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