Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process

Acetylcholinesterase (AChE) triggers beta amyloid plaques formation and is associated with amyloid plaques in the brain. Recent studies have demonstrated that AChE promotes the aggregation of PrP106-126, a peptide deduced from the prion protein sequence. In the present study we show that AChE trigge...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular neuroscience 2009-02, Vol.40 (2), p.217-224
Hauptverfasser:	Pera, M., Martínez-Otero, A., Colombo, L., Salmona, M., Ruiz-Molina, D., Badia, A., Clos, M.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - genetics Acetylcholinesterase - metabolism AChE peripheral site AChE peripheral site blockers Amyloid - chemistry Amyloid - metabolism Amyloid aggregation process Animals Anticoagulants - metabolism Cattle Coumarins - metabolism Gerstmann-Straussler-Scheinker Disease - metabolism Gerstmann-Straussler-Scheinker Disease - pathology Gerstmann-Sträussler-Scheinker disease Glycoproteins - genetics Glycoproteins - metabolism Humans Microscopy, Atomic Force Particle Size Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Plaque, Amyloid - chemistry Plaque, Amyloid - metabolism Prion protein Prions - chemistry Prions - genetics Prions - metabolism PrP82-146
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!