Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes

Modulation of the L-type Ca(2+) channel (LTCC) by sorcin was investigated by measuring the L-type Ca(2+) current (I (Ca,L)) in isolated rabbit ventricular myocytes using ruptured patch, single electrode voltage clamp in the absence of extracellular Na(+). Fifty millimolars EGTA (170 nM Ca(2+)) in th...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Pflügers Archiv 2009-03, Vol.457 (5), p.1049-1060
Hauptverfasser:	Fowler, Mark R, Colotti, Gianni, Chiancone, Emilia, Higuchi, Yoshiharu, Seidler, Tim, Smith, Godfrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Calcium Signaling - drug effects Calcium-Binding Proteins - pharmacology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Cyclic AMP-Dependent Protein Kinases - physiology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Myocytes, Cardiac - metabolism Protein Kinase Inhibitors - pharmacology Rabbits RNA Interference
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!