Role of ghrelin in the pathophysiology of eating behaviour
Ghrelin, the endogenous ligand for GHS-R, was isolated from rat stomach, although other tissues exist expressing ghrelin, such as pituitary, hypothalamus, placent, ovary, testes, etc. It was showed that ghrelin is implicated in GH secretion, in vivo and in vitro. There are direct evidences that proo...
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| Veröffentlicht in: | Revista de medicina de la Universidad de Navarra 2004-04, Vol.48 (2), p.11-17 |
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| creator | Seoane, L M Lage, M Al-Massadi, O Diéguez, C Casanueva, F F |
| description | Ghrelin, the endogenous ligand for GHS-R, was isolated from rat stomach, although other tissues exist expressing ghrelin, such as pituitary, hypothalamus, placent, ovary, testes, etc. It was showed that ghrelin is implicated in GH secretion, in vivo and in vitro. There are direct evidences that proof that ghrelin administration induces GH secretion. There are in vivo data, showing ghrelin as a most potent GH secretor than GHRH. Evidences exist of ghrelin actions in the regulation of food intake and energy homeostasis. Ghrelin has a clear role in the differents pathologies such as obesity, anorexia and bulimia. |
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There are direct evidences that proof that ghrelin administration induces GH secretion. There are in vivo data, showing ghrelin as a most potent GH secretor than GHRH. Evidences exist of ghrelin actions in the regulation of food intake and energy homeostasis. 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There are direct evidences that proof that ghrelin administration induces GH secretion. There are in vivo data, showing ghrelin as a most potent GH secretor than GHRH. Evidences exist of ghrelin actions in the regulation of food intake and energy homeostasis. 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| subjects | Agouti-Related Protein Animals Appetite - drug effects Appetite - physiology Energy Metabolism - physiology Feeding and Eating Disorders - physiopathology Feeding Behavior - physiology Ghrelin Growth Hormone - secretion Humans Hypothalamus - physiology Intercellular Signaling Peptides and Proteins Leptin - physiology Neuropeptide Y - physiology Peptide Hormones - pharmacology Peptide Hormones - physiology Proteins - physiology Rats Rats, Inbred Lew Rats, Mutant Strains Stomach - metabolism |
| title | Role of ghrelin in the pathophysiology of eating behaviour |
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