Impact of Bone Lead and Bone Resorption on Plasma and Whole Blood Lead Levels during Pregnancy
The authors tested the hypotheses that maternal bone lead burden is associated with increasing maternal whole blood and plasma lead levels over the course of pregnancy and that this association is modified by rates of maternal bone resorption. A total of 193 Mexican women were evaluated (1997–1999)...
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| Veröffentlicht in: | American journal of epidemiology 2004-10, Vol.160 (7), p.668-678 |
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| creator | Téllez-Rojo, Martha María Hernández-Avila, Mauricio Lamadrid-Figueroa, Héctor Smith, Donald Hernández-Cadena, Leticia Mercado, Adriana Aro, Antonio Schwartz, Joel Hu, Howard |
| description | The authors tested the hypotheses that maternal bone lead burden is associated with increasing maternal whole blood and plasma lead levels over the course of pregnancy and that this association is modified by rates of maternal bone resorption. A total of 193 Mexican women were evaluated (1997–1999) in the first, second, and third trimesters of pregnancy. Whole blood lead and plasma lead levels were measured in each trimester. Urine was analyzed for cross-linked N-telopeptides (NTx) of type I collagen, a biomarker of bone resorption. Patella and tibia lead levels were measured at 4 weeks postpartum. The relation between whole blood, plasma, and bone lead and NTx was assessed using mixed models. Plasma lead concentrations followed a U-shape, while NTx levels increased significantly during pregnancy. In a multivariate model, the authors observed a significant and positive interaction between NTx and bone lead when plasma lead was used as the outcome variable. Dietary calcium intake was inversely associated with plasma lead. Results for whole blood lead were similar but less pronounced. These results confirm previous evidence that bone resorption increases during pregnancy, with a consequential significant release of lead from bone, constituting an endogenous source of prenatal exposure. They also provide a rationale for testing strategies (e.g., nutritional supplementation with calcium) aimed at decreasing prenatal lead exposure. |
| doi_str_mv | 10.1093/aje/kwh271 |
| format | Article |
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A total of 193 Mexican women were evaluated (1997–1999) in the first, second, and third trimesters of pregnancy. Whole blood lead and plasma lead levels were measured in each trimester. Urine was analyzed for cross-linked N-telopeptides (NTx) of type I collagen, a biomarker of bone resorption. Patella and tibia lead levels were measured at 4 weeks postpartum. The relation between whole blood, plasma, and bone lead and NTx was assessed using mixed models. Plasma lead concentrations followed a U-shape, while NTx levels increased significantly during pregnancy. In a multivariate model, the authors observed a significant and positive interaction between NTx and bone lead when plasma lead was used as the outcome variable. Dietary calcium intake was inversely associated with plasma lead. Results for whole blood lead were similar but less pronounced. These results confirm previous evidence that bone resorption increases during pregnancy, with a consequential significant release of lead from bone, constituting an endogenous source of prenatal exposure. They also provide a rationale for testing strategies (e.g., nutritional supplementation with calcium) aimed at decreasing prenatal lead exposure.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>EISSN: 0002-9262</identifier><identifier>DOI: 10.1093/aje/kwh271</identifier><identifier>PMID: 15383411</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adolescent ; Adult ; Analysis. Health state ; BCE ; Biological and medical sciences ; Blood ; Bone and Bones - chemistry ; bone collagen equivalents ; Bone Resorption ; Bones ; Calcium, Dietary ; cross-linked N-telopeptides ; Epidemiology ; Female ; General aspects ; Humans ; Impact analysis ; Lead ; Lead - blood ; Longitudinal Studies ; Medical sciences ; Multivariate Analysis ; NTx ; Plasma ; Pregnancy ; Pregnancy - physiology ; Pregnancy Complications ; Public health. Hygiene ; Public health. Hygiene-occupational medicine</subject><ispartof>American journal of epidemiology, 2004-10, Vol.160 (7), p.668-678</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Oct 01, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-57e93aa268154a87a1c04ced37481981d414c11b1e671916ffad7bf98586f9493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16181252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15383411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Téllez-Rojo, Martha María</creatorcontrib><creatorcontrib>Hernández-Avila, Mauricio</creatorcontrib><creatorcontrib>Lamadrid-Figueroa, Héctor</creatorcontrib><creatorcontrib>Smith, Donald</creatorcontrib><creatorcontrib>Hernández-Cadena, Leticia</creatorcontrib><creatorcontrib>Mercado, Adriana</creatorcontrib><creatorcontrib>Aro, Antonio</creatorcontrib><creatorcontrib>Schwartz, Joel</creatorcontrib><creatorcontrib>Hu, Howard</creatorcontrib><title>Impact of Bone Lead and Bone Resorption on Plasma and Whole Blood Lead Levels during Pregnancy</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>The authors tested the hypotheses that maternal bone lead burden is associated with increasing maternal whole blood and plasma lead levels over the course of pregnancy and that this association is modified by rates of maternal bone resorption. A total of 193 Mexican women were evaluated (1997–1999) in the first, second, and third trimesters of pregnancy. Whole blood lead and plasma lead levels were measured in each trimester. Urine was analyzed for cross-linked N-telopeptides (NTx) of type I collagen, a biomarker of bone resorption. Patella and tibia lead levels were measured at 4 weeks postpartum. The relation between whole blood, plasma, and bone lead and NTx was assessed using mixed models. Plasma lead concentrations followed a U-shape, while NTx levels increased significantly during pregnancy. In a multivariate model, the authors observed a significant and positive interaction between NTx and bone lead when plasma lead was used as the outcome variable. Dietary calcium intake was inversely associated with plasma lead. Results for whole blood lead were similar but less pronounced. These results confirm previous evidence that bone resorption increases during pregnancy, with a consequential significant release of lead from bone, constituting an endogenous source of prenatal exposure. They also provide a rationale for testing strategies (e.g., nutritional supplementation with calcium) aimed at decreasing prenatal lead exposure.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis. Health state</subject><subject>BCE</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bone and Bones - chemistry</subject><subject>bone collagen equivalents</subject><subject>Bone Resorption</subject><subject>Bones</subject><subject>Calcium, Dietary</subject><subject>cross-linked N-telopeptides</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Impact analysis</subject><subject>Lead</subject><subject>Lead - blood</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>NTx</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Pregnancy - physiology</subject><subject>Pregnancy Complications</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><issn>0002-9262</issn><issn>1476-6256</issn><issn>0002-9262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgFrut3vgDZBD0Qhibk-9ctsW6LQsusqJ4YchmMu1sZyZrMlPtv2_aWVrwRgiEcJ6cfLwIvQb8EbCmR3bjj67_XBEJz9AMmBSlIFw8RzOMMSk1EWQfHaS0wRhAc_wC7QOnijKAGfp13m2tG4pQFyeh98XC26qwfTWtvvoU4nZoQl_ksWxt6uxD9ftVaH1x0oZQTVsW_sa3qajG2PSXxTL6y9727vYl2qttm_yr3XyIvp19Wp3Oy8WXz-enx4vScYCh5NJrai0RCjizSlpwmDlfUckUaAUVA-YA1uCFBA2irm0l17VWXIlaM00P0fup7zaG36NPg-ma5Hzb2t6HMRkhlFaa8f9CkFJLgUmGb_-BmzDGPj_CEJqPxYKxjD5MyMWQUvS12cams_HWADb32ZicjZmyyfjNruO47nz1RHdhZPBuB2xytq1j_sEmPTkBCgi_v1o5uSYN_u9j3cZrIySV3Mx__DQXc3qxWi2ZOaN3b2SkOg</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Téllez-Rojo, Martha María</creator><creator>Hernández-Avila, Mauricio</creator><creator>Lamadrid-Figueroa, Héctor</creator><creator>Smith, Donald</creator><creator>Hernández-Cadena, Leticia</creator><creator>Mercado, Adriana</creator><creator>Aro, Antonio</creator><creator>Schwartz, Joel</creator><creator>Hu, Howard</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Impact of Bone Lead and Bone Resorption on Plasma and Whole Blood Lead Levels during Pregnancy</title><author>Téllez-Rojo, Martha María ; Hernández-Avila, Mauricio ; Lamadrid-Figueroa, Héctor ; Smith, Donald ; Hernández-Cadena, Leticia ; Mercado, Adriana ; Aro, Antonio ; Schwartz, Joel ; Hu, Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-57e93aa268154a87a1c04ced37481981d414c11b1e671916ffad7bf98586f9493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis. Health state</topic><topic>BCE</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bone and Bones - chemistry</topic><topic>bone collagen equivalents</topic><topic>Bone Resorption</topic><topic>Bones</topic><topic>Calcium, Dietary</topic><topic>cross-linked N-telopeptides</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Impact analysis</topic><topic>Lead</topic><topic>Lead - blood</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>NTx</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>Pregnancy - physiology</topic><topic>Pregnancy Complications</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Téllez-Rojo, Martha María</creatorcontrib><creatorcontrib>Hernández-Avila, Mauricio</creatorcontrib><creatorcontrib>Lamadrid-Figueroa, Héctor</creatorcontrib><creatorcontrib>Smith, Donald</creatorcontrib><creatorcontrib>Hernández-Cadena, Leticia</creatorcontrib><creatorcontrib>Mercado, Adriana</creatorcontrib><creatorcontrib>Aro, Antonio</creatorcontrib><creatorcontrib>Schwartz, Joel</creatorcontrib><creatorcontrib>Hu, Howard</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Téllez-Rojo, Martha María</au><au>Hernández-Avila, Mauricio</au><au>Lamadrid-Figueroa, Héctor</au><au>Smith, Donald</au><au>Hernández-Cadena, Leticia</au><au>Mercado, Adriana</au><au>Aro, Antonio</au><au>Schwartz, Joel</au><au>Hu, Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Bone Lead and Bone Resorption on Plasma and Whole Blood Lead Levels during Pregnancy</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>160</volume><issue>7</issue><spage>668</spage><epage>678</epage><pages>668-678</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><eissn>0002-9262</eissn><coden>AJEPAS</coden><abstract>The authors tested the hypotheses that maternal bone lead burden is associated with increasing maternal whole blood and plasma lead levels over the course of pregnancy and that this association is modified by rates of maternal bone resorption. A total of 193 Mexican women were evaluated (1997–1999) in the first, second, and third trimesters of pregnancy. Whole blood lead and plasma lead levels were measured in each trimester. Urine was analyzed for cross-linked N-telopeptides (NTx) of type I collagen, a biomarker of bone resorption. Patella and tibia lead levels were measured at 4 weeks postpartum. The relation between whole blood, plasma, and bone lead and NTx was assessed using mixed models. Plasma lead concentrations followed a U-shape, while NTx levels increased significantly during pregnancy. In a multivariate model, the authors observed a significant and positive interaction between NTx and bone lead when plasma lead was used as the outcome variable. Dietary calcium intake was inversely associated with plasma lead. Results for whole blood lead were similar but less pronounced. These results confirm previous evidence that bone resorption increases during pregnancy, with a consequential significant release of lead from bone, constituting an endogenous source of prenatal exposure. They also provide a rationale for testing strategies (e.g., nutritional supplementation with calcium) aimed at decreasing prenatal lead exposure.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>15383411</pmid><doi>10.1093/aje/kwh271</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Adult Analysis. Health state BCE Biological and medical sciences Blood Bone and Bones - chemistry bone collagen equivalents Bone Resorption Bones Calcium, Dietary cross-linked N-telopeptides Epidemiology Female General aspects Humans Impact analysis Lead Lead - blood Longitudinal Studies Medical sciences Multivariate Analysis NTx Plasma Pregnancy Pregnancy - physiology Pregnancy Complications Public health. Hygiene Public health. Hygiene-occupational medicine |
| title | Impact of Bone Lead and Bone Resorption on Plasma and Whole Blood Lead Levels during Pregnancy |
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