Allicin inhibits spontaneous and TNF-α induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells

Background & aims: Allicin, the active substance of fresh crushed garlic has different biological activities and was implicated as an anti-inflammatory agent. Epithelial cells have an important role in intestinal inflammation. The aim of this study was to assess the immunomodulatory effect of al...

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Veröffentlicht in:	Clinical nutrition (Edinburgh, Scotland) Scotland), 2004-10, Vol.23 (5), p.1199-1208
Hauptverfasser:	Lang, Alon, Lahav, Maor, Sakhnini, Emad, Barshack, Iris, Fidder, Herma H., Avidan, Benjamin, Bardan, Eitan, Hershkoviz, Rami, Bar-Meir, Simon, Chowers, Yehuda
Format:	Artikel
Sprache:	eng
Schlagworte:	Allicin Anti-Infective Agents - pharmacology Biological and medical sciences Caco-2 Cells Chemokine CXCL10 - antagonists & inhibitors Chemokine CXCL10 - secretion Chemokines Cytokines Dose-Response Relationship, Immunologic Epithelial cells Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology HT29 Cells Humans Immunosuppressive Agents - pharmacology Interleukin-1 - antagonists & inhibitors Interleukin-1 - secretion Interleukin-8 - antagonists & inhibitors Interleukin-8 - secretion Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - secretion Intestine RNA, Messenger - metabolism Sulfinic Acids - pharmacology TNF-α Tumor Necrosis Factor-alpha - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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