A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder
Background To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). Methods Consecutive patients admitted to hospital after traumatic injury ( n = 155) were assessed for current psychiatric disorder, pain, and morphine d...
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| Veröffentlicht in: | Biological psychiatry (1969) 2009-03, Vol.65 (5), p.438-440 |
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| container_title | Biological psychiatry (1969) |
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| creator | Bryant, Richard A Creamer, Mark O'Donnell, Meaghan Silove, Derrick McFarlane, Alexander C |
| description | Background To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). Methods Consecutive patients admitted to hospital after traumatic injury ( n = 155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later ( n = 120). Results Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. Conclusions Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development. |
| doi_str_mv | 10.1016/j.biopsych.2008.10.032 |
| format | Article |
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Methods Consecutive patients admitted to hospital after traumatic injury ( n = 155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later ( n = 120). Results Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. Conclusions Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2008.10.032</identifier><identifier>PMID: 19058787</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - therapeutic use ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Fear ; Fear conditioning ; Female ; Humans ; Male ; Medical sciences ; morphine ; Morphine - administration & dosage ; Morphine - therapeutic use ; Post-traumatic stress disorder ; posttraumatic stress disorder ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Severity of Illness Index ; Stress Disorders, Post-Traumatic - prevention & control ; Time Factors ; Wounds and Injuries - complications ; Wounds and Injuries - drug therapy</subject><ispartof>Biological psychiatry (1969), 2009-03, Vol.65 (5), p.438-440</ispartof><rights>Society of Biological Psychiatry</rights><rights>2009 Society of Biological Psychiatry</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-588873750c896d957e0c666c61bc1f516840037035634d702a471f5369818e843</citedby><cites>FETCH-LOGICAL-c548t-588873750c896d957e0c666c61bc1f516840037035634d702a471f5369818e843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322308013218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21167535$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19058787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bryant, Richard A</creatorcontrib><creatorcontrib>Creamer, Mark</creatorcontrib><creatorcontrib>O'Donnell, Meaghan</creatorcontrib><creatorcontrib>Silove, Derrick</creatorcontrib><creatorcontrib>McFarlane, Alexander C</creatorcontrib><title>A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). Methods Consecutive patients admitted to hospital after traumatic injury ( n = 155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later ( n = 120). Results Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. Conclusions Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Fear</subject><subject>Fear conditioning</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - therapeutic use</subject><subject>Post-traumatic stress disorder</subject><subject>posttraumatic stress disorder</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Stress Disorders, Post-Traumatic - prevention & control</subject><subject>Time Factors</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - drug therapy</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1vEzEQhi0EoqHwFypf4Lbp2N61vRdE1FKKVESlwNnaeGcVh40dbG-l_Hu8SgCJCyfbM898-J0h5IrBkgGT17vlxoVDOtrtkgPoYlyC4M_IgmklKl4Df04WACArwbm4IK9S2pWn4py9JBeshUYrrRYkrOg6T_2RhoHmLdLHGDLa7J6Q3k2-XIKfXSs7ZaRfQjxsnUe66vfOu5RjdwI8XU-bhD8n9Jk-hpSLZ9oXpy3ZI6ZEb10Kscf4mrwYujHhm_N5Sb7fffx2c189fP30-Wb1UNmm1rlqtC7_UA1Y3cq-bRSClVJayTaWDQ2TugYQCkQjRd0r4F2til3IVjONuhaX5N0p7yGG0lbKZu-SxXHsPIYpGSl1q6FmBZQn0MaQUsTBHKLbd_FoGJhZarMzv6U2s9SzvUhdAq_OFabNHvu_YWdtC_D2DHTJduMQO29d-sNxxqRqRFO4DycOix5PDqNJ1qG32LtYRmH64P7fy_t_UtixDKhU_YFHTLswRV_UNswkbsCs58WY9wI0MMGZFr8AlQq0bQ</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Bryant, Richard A</creator><creator>Creamer, Mark</creator><creator>O'Donnell, Meaghan</creator><creator>Silove, Derrick</creator><creator>McFarlane, Alexander C</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder</title><author>Bryant, Richard A ; Creamer, Mark ; O'Donnell, Meaghan ; Silove, Derrick ; McFarlane, Alexander C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-588873750c896d957e0c666c61bc1f516840037035634d702a471f5369818e843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Fear</topic><topic>Fear conditioning</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - therapeutic use</topic><topic>Post-traumatic stress disorder</topic><topic>posttraumatic stress disorder</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Stress Disorders, Post-Traumatic - prevention & control</topic><topic>Time Factors</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bryant, Richard A</creatorcontrib><creatorcontrib>Creamer, Mark</creatorcontrib><creatorcontrib>O'Donnell, Meaghan</creatorcontrib><creatorcontrib>Silove, Derrick</creatorcontrib><creatorcontrib>McFarlane, Alexander C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bryant, Richard A</au><au>Creamer, Mark</au><au>O'Donnell, Meaghan</au><au>Silove, Derrick</au><au>McFarlane, Alexander C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>65</volume><issue>5</issue><spage>438</spage><epage>440</epage><pages>438-440</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). Methods Consecutive patients admitted to hospital after traumatic injury ( n = 155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later ( n = 120). Results Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. Conclusions Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19058787</pmid><doi>10.1016/j.biopsych.2008.10.032</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Analgesics, Opioid - administration & dosage Analgesics, Opioid - therapeutic use Anxiety disorders. Neuroses Biological and medical sciences Fear Fear conditioning Female Humans Male Medical sciences morphine Morphine - administration & dosage Morphine - therapeutic use Post-traumatic stress disorder posttraumatic stress disorder Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index Stress Disorders, Post-Traumatic - prevention & control Time Factors Wounds and Injuries - complications Wounds and Injuries - drug therapy |
| title | A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder |
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