Electrosynthesis of hydrogel films on metal substrates for the development of coatings with tunable drug delivery performances
Novel polyacrylates‐based hydrogel thin films were prepared by electrochemical polymerization, a new method to obtain hydrogels directly onto metal substrates. 2‐Hydroxy‐ethyl‐methacrylate (HEMA), a macromer poly (ethylene‐glycol diacrylate) (PEGDA) and PEGDA copolymerized with acrylic acid (AA) wer...
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| Veröffentlicht in: | Journal of Biomedical Materials Research Part B 2009-03, Vol.88A (4), p.1048-1057 |
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| container_title | Journal of Biomedical Materials Research Part B |
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| creator | De Giglio, E. Cometa, S. Satriano, C. Sabbatini, L. Zambonin, P. G. |
| description | Novel polyacrylates‐based hydrogel thin films were prepared by electrochemical polymerization, a new method to obtain hydrogels directly onto metal substrates. 2‐Hydroxy‐ethyl‐methacrylate (HEMA), a macromer poly (ethylene‐glycol diacrylate) (PEGDA) and PEGDA copolymerized with acrylic acid (AA) were used to obtain hydrogels. The electrosynthesized coatings were characterized by X‐ray photoelectron spectroscopy, to assess their surface chemical composition, and by water content determination measurements, to characterize the swelling behavior. In particular, quartz crystal microbalance with dissipation monitoring was used to evaluate the pH‐dependency of the swelling for AA‐containing hydrogels. Moreover, a model protein (bovine serum albumin) and a model drug (caffeine) were entrapped within the hydrogel coatings during electrosynthesis, to examine the release performances and mechanisms of the electrosynthesized hydrogels. It was observed that all the examined polymers showed significant release properties and, in particular, AA‐containing hydrogel films confirmed a strong pH‐dependence as expected. These coatings seem to be promising in orthopedic field for in situ drug delivery applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 |
| doi_str_mv | 10.1002/jbm.a.31908 |
| format | Article |
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Moreover, a model protein (bovine serum albumin) and a model drug (caffeine) were entrapped within the hydrogel coatings during electrosynthesis, to examine the release performances and mechanisms of the electrosynthesized hydrogels. It was observed that all the examined polymers showed significant release properties and, in particular, AA‐containing hydrogel films confirmed a strong pH‐dependence as expected. These coatings seem to be promising in orthopedic field for in situ drug delivery applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.a.31908</identifier><identifier>PMID: 18404708</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Caffeine - chemistry ; Caffeine - metabolism ; Coated Materials, Biocompatible - chemistry ; Drug Carriers - chemistry ; Drug Delivery Systems ; drug release ; Elasticity ; Electrochemical Techniques ; electrosynthesis ; hydrogel ; Hydrogels - chemistry ; Hydrogen-Ion Concentration ; Materials Testing ; Metals - chemistry ; Methacrylates - chemistry ; Serum Albumin, Bovine - chemistry ; Serum Albumin, Bovine - metabolism ; Surface Properties ; titanium ; Viscosity ; XPS</subject><ispartof>Journal of Biomedical Materials Research Part B, 2009-03, Vol.88A (4), p.1048-1057</ispartof><rights>Copyright © 2008 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4298-df7057c3e6a3ffe113fab3f73ce4fd096fa616363e1f7d61acd63fa099a76ac83</citedby><cites>FETCH-LOGICAL-c4298-df7057c3e6a3ffe113fab3f73ce4fd096fa616363e1f7d61acd63fa099a76ac83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.31908$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.31908$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18404708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Giglio, E.</creatorcontrib><creatorcontrib>Cometa, S.</creatorcontrib><creatorcontrib>Satriano, C.</creatorcontrib><creatorcontrib>Sabbatini, L.</creatorcontrib><creatorcontrib>Zambonin, P. G.</creatorcontrib><title>Electrosynthesis of hydrogel films on metal substrates for the development of coatings with tunable drug delivery performances</title><title>Journal of Biomedical Materials Research Part B</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Novel polyacrylates‐based hydrogel thin films were prepared by electrochemical polymerization, a new method to obtain hydrogels directly onto metal substrates. 2‐Hydroxy‐ethyl‐methacrylate (HEMA), a macromer poly (ethylene‐glycol diacrylate) (PEGDA) and PEGDA copolymerized with acrylic acid (AA) were used to obtain hydrogels. The electrosynthesized coatings were characterized by X‐ray photoelectron spectroscopy, to assess their surface chemical composition, and by water content determination measurements, to characterize the swelling behavior. In particular, quartz crystal microbalance with dissipation monitoring was used to evaluate the pH‐dependency of the swelling for AA‐containing hydrogels. Moreover, a model protein (bovine serum albumin) and a model drug (caffeine) were entrapped within the hydrogel coatings during electrosynthesis, to examine the release performances and mechanisms of the electrosynthesized hydrogels. It was observed that all the examined polymers showed significant release properties and, in particular, AA‐containing hydrogel films confirmed a strong pH‐dependence as expected. These coatings seem to be promising in orthopedic field for in situ drug delivery applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</description><subject>Animals</subject><subject>Caffeine - chemistry</subject><subject>Caffeine - metabolism</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>drug release</subject><subject>Elasticity</subject><subject>Electrochemical Techniques</subject><subject>electrosynthesis</subject><subject>hydrogel</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Materials Testing</subject><subject>Metals - chemistry</subject><subject>Methacrylates - chemistry</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Serum Albumin, Bovine - metabolism</subject><subject>Surface Properties</subject><subject>titanium</subject><subject>Viscosity</subject><subject>XPS</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cFv0zAYBXALgdgYnLgjn7igFDtO7PgI09qBCkhoCImL5TifWw8nKbazkQt_-1xa4MZOsaLfe5b8EHpOyYISUr6-bvuFXjAqSfMAndK6LotK8vrh_lzJgpWSn6AnMV5nzEldPkYntKlIJUhzin5deDApjHEe0haii3i0eDt3YdyAx9b5Pv8ZcA9JexynNqagE0Rsx4BzAHdwA37c9TCkfdKMOrlhE_GtS1ucpkG3PqMwbbL07gbCjHcQcrrXg4H4FD2y2kd4dvyeoS_Li6vzy2L9afXu_M26MFUpm6KzgtTCMOCaWQuUMqtbZgUzUNmOSG41p5xxBtSKjlNtOp4JkVILrk3DztDLQ-8ujD8miEn1LhrwXg8wTlFx3kjRCHIvZLWUhLPqXliSWrJS7K9-dYAmv3IMYNUuuF6HWVGi9gOqPKDS6veAWb841k5tD90_e1wsA3oAt87D_L8u9f7thz-lxSHjYoKffzM6fFdcMFGrrx9X6vNquVyLq2-KsTtr9rj0</recordid><startdate>20090315</startdate><enddate>20090315</enddate><creator>De Giglio, E.</creator><creator>Cometa, S.</creator><creator>Satriano, C.</creator><creator>Sabbatini, L.</creator><creator>Zambonin, P. 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G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4298-df7057c3e6a3ffe113fab3f73ce4fd096fa616363e1f7d61acd63fa099a76ac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Caffeine - chemistry</topic><topic>Caffeine - metabolism</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>drug release</topic><topic>Elasticity</topic><topic>Electrochemical Techniques</topic><topic>electrosynthesis</topic><topic>hydrogel</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Materials Testing</topic><topic>Metals - chemistry</topic><topic>Methacrylates - chemistry</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Serum Albumin, Bovine - metabolism</topic><topic>Surface Properties</topic><topic>titanium</topic><topic>Viscosity</topic><topic>XPS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Giglio, E.</creatorcontrib><creatorcontrib>Cometa, S.</creatorcontrib><creatorcontrib>Satriano, C.</creatorcontrib><creatorcontrib>Sabbatini, L.</creatorcontrib><creatorcontrib>Zambonin, P. 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| subjects | Animals Caffeine - chemistry Caffeine - metabolism Coated Materials, Biocompatible - chemistry Drug Carriers - chemistry Drug Delivery Systems drug release Elasticity Electrochemical Techniques electrosynthesis hydrogel Hydrogels - chemistry Hydrogen-Ion Concentration Materials Testing Metals - chemistry Methacrylates - chemistry Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism Surface Properties titanium Viscosity XPS |
| title | Electrosynthesis of hydrogel films on metal substrates for the development of coatings with tunable drug delivery performances |
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