Characterization of a novel immunoglobulin-like domain containing receptor
A not yet described gene was identified in a lymphoma specific subtraction strategy. Three splice variants of this gene denoted immunoglobulin-like domain containing receptor 1 (ILDR1) were identified and characterized. Cellular localization studies showed membrane-association for two of the variant...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2004-10, Vol.323 (3), p.970-978 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Hauge, Helena Patzke, Sebastian Delabie, Jan Aasheim, Hans-Christian |
| description | A not yet described gene was identified in a lymphoma specific subtraction strategy. Three splice variants of this gene denoted immunoglobulin-like domain containing receptor 1 (ILDR1) were identified and characterized. Cellular localization studies showed membrane-association for two of the variants, while the third was cytoplasmic and appeared to translocate to the membrane upon co-expression with any of the other two isoforms. ILDR1 shows approximately 30% homology to a recently described protein from rat, lipolysis stimulated receptor, that has been shown to bind low-density lipoprotein. The gene encoding ILDR1 is localized to chromosome 3q21.1 and it is expressed in prostate, testis, pancreas, kidney, liver, and heart. Interestingly, the shortest transcript corresponding to the cytoplasmic variant could only be detected in lymphoma samples and not in normal tissues or cell lines tested. The expression of this variant may therefore be related to the development and/or progression of cancer. |
| doi_str_mv | 10.1016/j.bbrc.2004.08.188 |
| format | Article |
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Three splice variants of this gene denoted immunoglobulin-like domain containing receptor 1 (ILDR1) were identified and characterized. Cellular localization studies showed membrane-association for two of the variants, while the third was cytoplasmic and appeared to translocate to the membrane upon co-expression with any of the other two isoforms. ILDR1 shows approximately 30% homology to a recently described protein from rat, lipolysis stimulated receptor, that has been shown to bind low-density lipoprotein. The gene encoding ILDR1 is localized to chromosome 3q21.1 and it is expressed in prostate, testis, pancreas, kidney, liver, and heart. Interestingly, the shortest transcript corresponding to the cytoplasmic variant could only be detected in lymphoma samples and not in normal tissues or cell lines tested. 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Three splice variants of this gene denoted immunoglobulin-like domain containing receptor 1 (ILDR1) were identified and characterized. Cellular localization studies showed membrane-association for two of the variants, while the third was cytoplasmic and appeared to translocate to the membrane upon co-expression with any of the other two isoforms. ILDR1 shows approximately 30% homology to a recently described protein from rat, lipolysis stimulated receptor, that has been shown to bind low-density lipoprotein. The gene encoding ILDR1 is localized to chromosome 3q21.1 and it is expressed in prostate, testis, pancreas, kidney, liver, and heart. Interestingly, the shortest transcript corresponding to the cytoplasmic variant could only be detected in lymphoma samples and not in normal tissues or cell lines tested. The expression of this variant may therefore be related to the development and/or progression of cancer.</description><subject>Alternative splicing</subject><subject>Amino Acid Sequence</subject><subject>Biomarkers, Tumor - chemistry</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Diagnostic marker</subject><subject>Gene expression</subject><subject>Humans</subject><subject>ILDR1</subject><subject>Lymphoma - chemistry</subject><subject>Lymphoma - genetics</subject><subject>Lymphoma - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Organ Specificity</subject><subject>Receptors, Cell Surface - chemistry</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Sequence Analysis, Protein</subject><subject>Sequence Homology, Amino Acid</subject><subject>Subcellular Fractions - metabolism</subject><subject>Tissue Distribution</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1OwzAYRS0EouXnBRhQJraEz4kTxxILqvgVEgtIbJbrfCkuiV3spBI8Pa5aiQ2mO9xz73AIOaOQUaDV5TKbz73OcgCWQZ3Rut4jUwoC0pwC2ydTAKjSXNC3CTkKYQlAKavEIZnQsqgjWE7J4-xdeaUH9OZbDcbZxLWJSqxbY5eYvh-tW3RuPnbGpp35wKRxvTI20c4OMY1dJB41rgbnT8hBq7qAp7s8Jq-3Ny-z-_Tp-e5hdv2UaiaKIVVKcCGQ8oLWDWs1thxLVnGmNfC2bnLkooKqKDhiIwBLLWIwYGXsALA4Jhfb35V3nyOGQfYmaOw6ZdGNQVZVLXjk_wUp52XO-AbMt6D2LgSPrVx50yv_JSnIjWq5lBvVcqNaQi2j6jg6372P8x6b38nObQSutgBGGWuDXgZt0GpsTFQ2yMaZv_5_ADncj_E</recordid><startdate>20041022</startdate><enddate>20041022</enddate><creator>Hauge, Helena</creator><creator>Patzke, Sebastian</creator><creator>Delabie, Jan</creator><creator>Aasheim, Hans-Christian</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20041022</creationdate><title>Characterization of a novel immunoglobulin-like domain containing receptor</title><author>Hauge, Helena ; 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Three splice variants of this gene denoted immunoglobulin-like domain containing receptor 1 (ILDR1) were identified and characterized. Cellular localization studies showed membrane-association for two of the variants, while the third was cytoplasmic and appeared to translocate to the membrane upon co-expression with any of the other two isoforms. ILDR1 shows approximately 30% homology to a recently described protein from rat, lipolysis stimulated receptor, that has been shown to bind low-density lipoprotein. The gene encoding ILDR1 is localized to chromosome 3q21.1 and it is expressed in prostate, testis, pancreas, kidney, liver, and heart. Interestingly, the shortest transcript corresponding to the cytoplasmic variant could only be detected in lymphoma samples and not in normal tissues or cell lines tested. 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| subjects | Alternative splicing Amino Acid Sequence Biomarkers, Tumor - chemistry Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cell Line, Tumor Diagnostic marker Gene expression Humans ILDR1 Lymphoma - chemistry Lymphoma - genetics Lymphoma - metabolism Molecular Sequence Data Organ Specificity Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Sequence Analysis, Protein Sequence Homology, Amino Acid Subcellular Fractions - metabolism Tissue Distribution |
| title | Characterization of a novel immunoglobulin-like domain containing receptor |
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