Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation
Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel func...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2004-09, Vol.110 (12), p.1645-1649 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | HARRIS, William S SANDS, Scott A WINDSOR, Sheryl L ALI, Hakim A STEVENS, Tracy L MAGALSKI, Anthony PORTER, Charles B BORKON, A. Michael |
| description | Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans.
We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g/d) on the FA composition of human cardiac and buccal tissue, RBCs, and plasma lipids in 25 other patients. Cardiac and RBC EPA+DHA levels were highly correlated (r=0.82, P |
| doi_str_mv | 10.1161/01.CIR.0000142292.10048.B2 |
| format | Article |
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We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g/d) on the FA composition of human cardiac and buccal tissue, RBCs, and plasma lipids in 25 other patients. Cardiac and RBC EPA+DHA levels were highly correlated (r=0.82, P<0.001). Supplementation increased EPA+DHA levels in cardiac tissue by 110%, in RBCs by 101%, in plasma by 139%, and in cheek cells by 73% (P<0.005 versus baseline for all; responses among tissues were not significantly different).
Although any of the tissues examined could serve as a surrogate for cardiac omega-3 FA content, RBC EPA+DHA was highly correlated with cardiac EPA+DHA; the RBC omega-3 response to supplementation was similar to that of the heart; RBCs are easily collected and analyzed; and they have a less variable FA composition than plasma. Therefore, RBC EPA+DHA (also called the Omega-3 Index) may be the preferred surrogate for cardiac omega-3 FA status.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000142292.10048.B2</identifier><identifier>PMID: 15353491</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Animals ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiac Catheterization ; Cardiology. Vascular system ; Cheek ; Cross-Sectional Studies ; Dietary Fats, Unsaturated - pharmacology ; Dietary Supplements ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Docosahexaenoic Acids - analysis ; Erythrocytes - chemistry ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - analysis ; Fatty Acids, Omega-3 - blood ; Fatty Acids, Omega-3 - pharmacology ; Female ; Fish Oils - administration & dosage ; Fish Oils - pharmacology ; Fishes ; General and cellular metabolism. Vitamins ; Heart ; Heart - drug effects ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart Transplantation ; Humans ; Lipids - blood ; Lipoproteins - blood ; Male ; Meat ; Medical sciences ; Middle Aged ; Mouth Mucosa - chemistry ; Mouth Mucosa - drug effects ; Myocardium - chemistry ; Myocardium - pathology ; Organ Specificity ; Pharmacology. Drug treatments</subject><ispartof>Circulation (New York, N.Y.), 2004-09, Vol.110 (12), p.1645-1649</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c331t-7ae46ba5a9c3900fe083756d392f0b1f35d4ac0bcfc48872de3e4c56a1b28d8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16460758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15353491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARRIS, William S</creatorcontrib><creatorcontrib>SANDS, Scott A</creatorcontrib><creatorcontrib>WINDSOR, Sheryl L</creatorcontrib><creatorcontrib>ALI, Hakim A</creatorcontrib><creatorcontrib>STEVENS, Tracy L</creatorcontrib><creatorcontrib>MAGALSKI, Anthony</creatorcontrib><creatorcontrib>PORTER, Charles B</creatorcontrib><creatorcontrib>BORKON, A. Michael</creatorcontrib><title>Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans.
We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g/d) on the FA composition of human cardiac and buccal tissue, RBCs, and plasma lipids in 25 other patients. Cardiac and RBC EPA+DHA levels were highly correlated (r=0.82, P<0.001). Supplementation increased EPA+DHA levels in cardiac tissue by 110%, in RBCs by 101%, in plasma by 139%, and in cheek cells by 73% (P<0.005 versus baseline for all; responses among tissues were not significantly different).
Although any of the tissues examined could serve as a surrogate for cardiac omega-3 FA content, RBC EPA+DHA was highly correlated with cardiac EPA+DHA; the RBC omega-3 response to supplementation was similar to that of the heart; RBCs are easily collected and analyzed; and they have a less variable FA composition than plasma. Therefore, RBC EPA+DHA (also called the Omega-3 Index) may be the preferred surrogate for cardiac omega-3 FA status.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiac Catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Cheek</subject><subject>Cross-Sectional Studies</subject><subject>Dietary Fats, Unsaturated - pharmacology</subject><subject>Dietary Supplements</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Docosahexaenoic Acids - analysis</subject><subject>Erythrocytes - chemistry</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - analysis</subject><subject>Fatty Acids, Omega-3 - blood</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Female</subject><subject>Fish Oils - administration & dosage</subject><subject>Fish Oils - pharmacology</subject><subject>Fishes</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Heart Transplantation</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Meat</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - chemistry</subject><subject>Mouth Mucosa - drug effects</subject><subject>Myocardium - chemistry</subject><subject>Myocardium - pathology</subject><subject>Organ Specificity</subject><subject>Pharmacology. Drug treatments</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd-K1TAQxoMo7tnVV5Ag6F1r_jVt98496LqwsCB6HabpxBNpm5rkIOcVfGqjp3DmZpjhN98w8xHylrOac80_MF7vH77WrARXQvSi5oyprr4Tz8iON0JVqpH9c7IrQF-1Uogrcp3Sz1Jq2TYvyRVvZCNVz3fkz9OMP6CS1EHOJwrWj4n6hVqIowdLBx_W5DFRF8NMDwgx0xxhSesES4bsw0LXknDJ6ZbuQ4w4nbu_fT5QjKd8iMGecpGAZaQR0xqWhDQHmo7rOuGMm84r8sLBlPD1lm_I98-fvu2_VI9P9w_7j4-VlZLnqgVUeoAGeit7xhyyrhylR9kLxwbuZDMqsGywzqqua8WIEpVtNPBBdGPn5A15f9ZdY_h1xJTN7JPFqRyE4ZiM1l2ve8kLeHsGbQwpRXRmjX6GeDKcmX9OGMZNccJcnDD_nTB3ogy_2bYchxnHy-j2-gK82wBIFiZXnmp9unBaadY2nfwL8ZeVug</recordid><startdate>20040921</startdate><enddate>20040921</enddate><creator>HARRIS, William S</creator><creator>SANDS, Scott A</creator><creator>WINDSOR, Sheryl L</creator><creator>ALI, Hakim A</creator><creator>STEVENS, Tracy L</creator><creator>MAGALSKI, Anthony</creator><creator>PORTER, Charles B</creator><creator>BORKON, A. Michael</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040921</creationdate><title>Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation</title><author>HARRIS, William S ; SANDS, Scott A ; WINDSOR, Sheryl L ; ALI, Hakim A ; STEVENS, Tracy L ; MAGALSKI, Anthony ; PORTER, Charles B ; BORKON, A. Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-7ae46ba5a9c3900fe083756d392f0b1f35d4ac0bcfc48872de3e4c56a1b28d8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiac Catheterization</topic><topic>Cardiology. Vascular system</topic><topic>Cheek</topic><topic>Cross-Sectional Studies</topic><topic>Dietary Fats, Unsaturated - pharmacology</topic><topic>Dietary Supplements</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Docosahexaenoic Acids - analysis</topic><topic>Erythrocytes - chemistry</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - analysis</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Fatty Acids, Omega-3 - pharmacology</topic><topic>Female</topic><topic>Fish Oils - administration & dosage</topic><topic>Fish Oils - pharmacology</topic><topic>Fishes</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Heart Transplantation</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>Meat</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - chemistry</topic><topic>Mouth Mucosa - drug effects</topic><topic>Myocardium - chemistry</topic><topic>Myocardium - pathology</topic><topic>Organ Specificity</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARRIS, William S</creatorcontrib><creatorcontrib>SANDS, Scott A</creatorcontrib><creatorcontrib>WINDSOR, Sheryl L</creatorcontrib><creatorcontrib>ALI, Hakim A</creatorcontrib><creatorcontrib>STEVENS, Tracy L</creatorcontrib><creatorcontrib>MAGALSKI, Anthony</creatorcontrib><creatorcontrib>PORTER, Charles B</creatorcontrib><creatorcontrib>BORKON, A. Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARRIS, William S</au><au>SANDS, Scott A</au><au>WINDSOR, Sheryl L</au><au>ALI, Hakim A</au><au>STEVENS, Tracy L</au><au>MAGALSKI, Anthony</au><au>PORTER, Charles B</au><au>BORKON, A. Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2004-09-21</date><risdate>2004</risdate><volume>110</volume><issue>12</issue><spage>1645</spage><epage>1649</epage><pages>1645-1649</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans.
We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g/d) on the FA composition of human cardiac and buccal tissue, RBCs, and plasma lipids in 25 other patients. Cardiac and RBC EPA+DHA levels were highly correlated (r=0.82, P<0.001). Supplementation increased EPA+DHA levels in cardiac tissue by 110%, in RBCs by 101%, in plasma by 139%, and in cheek cells by 73% (P<0.005 versus baseline for all; responses among tissues were not significantly different).
Although any of the tissues examined could serve as a surrogate for cardiac omega-3 FA content, RBC EPA+DHA was highly correlated with cardiac EPA+DHA; the RBC omega-3 response to supplementation was similar to that of the heart; RBCs are easily collected and analyzed; and they have a less variable FA composition than plasma. Therefore, RBC EPA+DHA (also called the Omega-3 Index) may be the preferred surrogate for cardiac omega-3 FA status.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15353491</pmid><doi>10.1161/01.CIR.0000142292.10048.B2</doi><tpages>5</tpages></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2004-09, Vol.110 (12), p.1645-1649 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Animals Biological and medical sciences Blood and lymphatic vessels Cardiac Catheterization Cardiology. Vascular system Cheek Cross-Sectional Studies Dietary Fats, Unsaturated - pharmacology Dietary Supplements Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Docosahexaenoic Acids - analysis Erythrocytes - chemistry Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - analysis Fatty Acids, Omega-3 - blood Fatty Acids, Omega-3 - pharmacology Female Fish Oils - administration & dosage Fish Oils - pharmacology Fishes General and cellular metabolism. Vitamins Heart Heart - drug effects Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Transplantation Humans Lipids - blood Lipoproteins - blood Male Meat Medical sciences Middle Aged Mouth Mucosa - chemistry Mouth Mucosa - drug effects Myocardium - chemistry Myocardium - pathology Organ Specificity Pharmacology. Drug treatments |
| title | Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation |
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