Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice

Abstract Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 in...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2009-03, Vol.130 (3), p.322-330
Hauptverfasser:	Nobumoto, Atsuya, Oomizu, Souichi, Arikawa, Tomohiro, Katoh, Shigeki, Nagahara, Keiko, Miyake, Minoru, Nishi, Nozomu, Takeshita, Keisuke, Niki, Toshiro, Yamauchi, Akira, Hirashima, Mitsuomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anti-tumor activity B16F10 melanoma Biological and medical sciences Cell Line, Tumor Dendritic Cells - immunology Dermatology Female Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Galectin-9 Galectins - metabolism Galectins - pharmacology Killer Cells, Natural - immunology Lymphocyte Activation Macrophage Macrophages - drug effects Macrophages - immunology Medical sciences Mice Mice, Inbred C57BL Neoplasms - immunology NK cell Phenotype Plasmacytoid dendritic cell Time Factors Tumors of the skin and soft tissue. Premalignant lesions
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