Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice
Abstract Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 in...
Gespeichert in:
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2009-03, Vol.130 (3), p.322-330 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 330 |
|---|---|
| container_issue | 3 |
| container_start_page | 322 |
| container_title | Clinical immunology (Orlando, Fla.) |
| container_volume | 130 |
| creator | Nobumoto, Atsuya Oomizu, Souichi Arikawa, Tomohiro Katoh, Shigeki Nagahara, Keiko Miyake, Minoru Nishi, Nozomu Takeshita, Keisuke Niki, Toshiro Yamauchi, Akira Hirashima, Mitsuomi |
| description | Abstract Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 increased the numbers of NK cells, CD8 T cells and macrophages in tumor-bearing mice. Gal-9-mediated anti-tumor activity was not induced in NK cell-, macrophage- and CD8 T cell-depleted mice. NK cells from Gal-9-treated mice, compared to PBS-treated mice, exhibited significantly higher cytolytic activity. Co-culture of naïve NK cells with macrophages from Gal-9-treated mice resulted in enhanced NK activity, although Gal-9 itself did not enhance the NK activity. We also found that Ly-6C+ CD11b+ F4/80+ macrophages with plasmacytoid cell (pDC)-like phenotypes (PDCA-1 and B220) were responsible for the enhanced NK activity. These results provide evidence that Gal-9 promotes NK cell-mediated anti-tumor activity by expanding unique macrophages with a pDC-like phenotype. |
| doi_str_mv | 10.1016/j.clim.2008.09.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66896820</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1521661608008310</els_id><sourcerecordid>20357759</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-4b89ade9b5ad6db25feba35d01c20fe9467c05852f34b555bfc0b2254d6879993</originalsourceid><addsrcrecordid>eNqFks-O1SAUxhujcf7oC7gwbHTXeqCFlsSYTCY6Gie6UNeEwulc7rS0QjvxPoJvPdTbaOJCVxDO7_s4nI8se0ahoEDFq31hejcUDKApQBZAqwfZKeWM5jWU_OG2F4KKk-wsxj0AcMbE4-yENrKugJWn2c8r3aOZnc8lwR-T9jaSxbvvC5JBmzBOO32DMZV2rnUJuyFTr2MqHebRWWLR25DODTHY93nvbpFMO_TjfJiSbN7pmehkf6dnJJ8-_qIicZ7MyzCGvEUdVs_BGXySPep0H_Hptp5n3969_Xr5Pr_-fPXh8uI6N1UNc161jdQWZcu1FbZlvMNWl9wCNQw6lJWoDfCGs66sWs552xloGeOVFU0tpSzPs5dH3ymM6ZlxVoOLa1_a47hEJUQjRcPgv2BCeF3z1ZEdwTSvGAN2agpu0OGgKKg1KbVXa1JqTUqBVCmpJHq-uS_tgPaPZIsmAS82QEej-y5ob1z8zTFKJQioE_f6yGEa2p3DoKJx6A1aF1Kyyo7u3328-UueEO_Sjbd4wLgfl-BTHIqqyBSoL-ufWr8UNMmkpFDeA1scyO4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20357759</pqid></control><display><type>article</type><title>Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Nobumoto, Atsuya ; Oomizu, Souichi ; Arikawa, Tomohiro ; Katoh, Shigeki ; Nagahara, Keiko ; Miyake, Minoru ; Nishi, Nozomu ; Takeshita, Keisuke ; Niki, Toshiro ; Yamauchi, Akira ; Hirashima, Mitsuomi</creator><creatorcontrib>Nobumoto, Atsuya ; Oomizu, Souichi ; Arikawa, Tomohiro ; Katoh, Shigeki ; Nagahara, Keiko ; Miyake, Minoru ; Nishi, Nozomu ; Takeshita, Keisuke ; Niki, Toshiro ; Yamauchi, Akira ; Hirashima, Mitsuomi</creatorcontrib><description>Abstract Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 increased the numbers of NK cells, CD8 T cells and macrophages in tumor-bearing mice. Gal-9-mediated anti-tumor activity was not induced in NK cell-, macrophage- and CD8 T cell-depleted mice. NK cells from Gal-9-treated mice, compared to PBS-treated mice, exhibited significantly higher cytolytic activity. Co-culture of naïve NK cells with macrophages from Gal-9-treated mice resulted in enhanced NK activity, although Gal-9 itself did not enhance the NK activity. We also found that Ly-6C+ CD11b+ F4/80+ macrophages with plasmacytoid cell (pDC)-like phenotypes (PDCA-1 and B220) were responsible for the enhanced NK activity. These results provide evidence that Gal-9 promotes NK cell-mediated anti-tumor activity by expanding unique macrophages with a pDC-like phenotype.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2008.09.014</identifier><identifier>PMID: 18974023</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Allergy and Immunology ; Animals ; Anti-tumor activity ; B16F10 melanoma ; Biological and medical sciences ; Cell Line, Tumor ; Dendritic Cells - immunology ; Dermatology ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Galectin-9 ; Galectins - metabolism ; Galectins - pharmacology ; Killer Cells, Natural - immunology ; Lymphocyte Activation ; Macrophage ; Macrophages - drug effects ; Macrophages - immunology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Neoplasms - immunology ; NK cell ; Phenotype ; Plasmacytoid dendritic cell ; Time Factors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Clinical immunology (Orlando, Fla.), 2009-03, Vol.130 (3), p.322-330</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-4b89ade9b5ad6db25feba35d01c20fe9467c05852f34b555bfc0b2254d6879993</citedby><cites>FETCH-LOGICAL-c470t-4b89ade9b5ad6db25feba35d01c20fe9467c05852f34b555bfc0b2254d6879993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661608008310$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21190607$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18974023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nobumoto, Atsuya</creatorcontrib><creatorcontrib>Oomizu, Souichi</creatorcontrib><creatorcontrib>Arikawa, Tomohiro</creatorcontrib><creatorcontrib>Katoh, Shigeki</creatorcontrib><creatorcontrib>Nagahara, Keiko</creatorcontrib><creatorcontrib>Miyake, Minoru</creatorcontrib><creatorcontrib>Nishi, Nozomu</creatorcontrib><creatorcontrib>Takeshita, Keisuke</creatorcontrib><creatorcontrib>Niki, Toshiro</creatorcontrib><creatorcontrib>Yamauchi, Akira</creatorcontrib><creatorcontrib>Hirashima, Mitsuomi</creatorcontrib><title>Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 increased the numbers of NK cells, CD8 T cells and macrophages in tumor-bearing mice. Gal-9-mediated anti-tumor activity was not induced in NK cell-, macrophage- and CD8 T cell-depleted mice. NK cells from Gal-9-treated mice, compared to PBS-treated mice, exhibited significantly higher cytolytic activity. Co-culture of naïve NK cells with macrophages from Gal-9-treated mice resulted in enhanced NK activity, although Gal-9 itself did not enhance the NK activity. We also found that Ly-6C+ CD11b+ F4/80+ macrophages with plasmacytoid cell (pDC)-like phenotypes (PDCA-1 and B220) were responsible for the enhanced NK activity. These results provide evidence that Gal-9 promotes NK cell-mediated anti-tumor activity by expanding unique macrophages with a pDC-like phenotype.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Anti-tumor activity</subject><subject>B16F10 melanoma</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Dendritic Cells - immunology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Galectin-9</subject><subject>Galectins - metabolism</subject><subject>Galectins - pharmacology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Activation</subject><subject>Macrophage</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasms - immunology</subject><subject>NK cell</subject><subject>Phenotype</subject><subject>Plasmacytoid dendritic cell</subject><subject>Time Factors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-O1SAUxhujcf7oC7gwbHTXeqCFlsSYTCY6Gie6UNeEwulc7rS0QjvxPoJvPdTbaOJCVxDO7_s4nI8se0ahoEDFq31hejcUDKApQBZAqwfZKeWM5jWU_OG2F4KKk-wsxj0AcMbE4-yENrKugJWn2c8r3aOZnc8lwR-T9jaSxbvvC5JBmzBOO32DMZV2rnUJuyFTr2MqHebRWWLR25DODTHY93nvbpFMO_TjfJiSbN7pmehkf6dnJJ8-_qIicZ7MyzCGvEUdVs_BGXySPep0H_Hptp5n3969_Xr5Pr_-fPXh8uI6N1UNc161jdQWZcu1FbZlvMNWl9wCNQw6lJWoDfCGs66sWs552xloGeOVFU0tpSzPs5dH3ymM6ZlxVoOLa1_a47hEJUQjRcPgv2BCeF3z1ZEdwTSvGAN2agpu0OGgKKg1KbVXa1JqTUqBVCmpJHq-uS_tgPaPZIsmAS82QEej-y5ob1z8zTFKJQioE_f6yGEa2p3DoKJx6A1aF1Kyyo7u3328-UueEO_Sjbd4wLgfl-BTHIqqyBSoL-ufWr8UNMmkpFDeA1scyO4</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Nobumoto, Atsuya</creator><creator>Oomizu, Souichi</creator><creator>Arikawa, Tomohiro</creator><creator>Katoh, Shigeki</creator><creator>Nagahara, Keiko</creator><creator>Miyake, Minoru</creator><creator>Nishi, Nozomu</creator><creator>Takeshita, Keisuke</creator><creator>Niki, Toshiro</creator><creator>Yamauchi, Akira</creator><creator>Hirashima, Mitsuomi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice</title><author>Nobumoto, Atsuya ; Oomizu, Souichi ; Arikawa, Tomohiro ; Katoh, Shigeki ; Nagahara, Keiko ; Miyake, Minoru ; Nishi, Nozomu ; Takeshita, Keisuke ; Niki, Toshiro ; Yamauchi, Akira ; Hirashima, Mitsuomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-4b89ade9b5ad6db25feba35d01c20fe9467c05852f34b555bfc0b2254d6879993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Anti-tumor activity</topic><topic>B16F10 melanoma</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Dendritic Cells - immunology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Galectin-9</topic><topic>Galectins - metabolism</topic><topic>Galectins - pharmacology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Activation</topic><topic>Macrophage</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasms - immunology</topic><topic>NK cell</topic><topic>Phenotype</topic><topic>Plasmacytoid dendritic cell</topic><topic>Time Factors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nobumoto, Atsuya</creatorcontrib><creatorcontrib>Oomizu, Souichi</creatorcontrib><creatorcontrib>Arikawa, Tomohiro</creatorcontrib><creatorcontrib>Katoh, Shigeki</creatorcontrib><creatorcontrib>Nagahara, Keiko</creatorcontrib><creatorcontrib>Miyake, Minoru</creatorcontrib><creatorcontrib>Nishi, Nozomu</creatorcontrib><creatorcontrib>Takeshita, Keisuke</creatorcontrib><creatorcontrib>Niki, Toshiro</creatorcontrib><creatorcontrib>Yamauchi, Akira</creatorcontrib><creatorcontrib>Hirashima, Mitsuomi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nobumoto, Atsuya</au><au>Oomizu, Souichi</au><au>Arikawa, Tomohiro</au><au>Katoh, Shigeki</au><au>Nagahara, Keiko</au><au>Miyake, Minoru</au><au>Nishi, Nozomu</au><au>Takeshita, Keisuke</au><au>Niki, Toshiro</au><au>Yamauchi, Akira</au><au>Hirashima, Mitsuomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>130</volume><issue>3</issue><spage>322</spage><epage>330</epage><pages>322-330</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>Abstract Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 increased the numbers of NK cells, CD8 T cells and macrophages in tumor-bearing mice. Gal-9-mediated anti-tumor activity was not induced in NK cell-, macrophage- and CD8 T cell-depleted mice. NK cells from Gal-9-treated mice, compared to PBS-treated mice, exhibited significantly higher cytolytic activity. Co-culture of naïve NK cells with macrophages from Gal-9-treated mice resulted in enhanced NK activity, although Gal-9 itself did not enhance the NK activity. We also found that Ly-6C+ CD11b+ F4/80+ macrophages with plasmacytoid cell (pDC)-like phenotypes (PDCA-1 and B220) were responsible for the enhanced NK activity. These results provide evidence that Gal-9 promotes NK cell-mediated anti-tumor activity by expanding unique macrophages with a pDC-like phenotype.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18974023</pmid><doi>10.1016/j.clim.2008.09.014</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1521-6616 |
| ispartof | Clinical immunology (Orlando, Fla.), 2009-03, Vol.130 (3), p.322-330 |
| issn | 1521-6616 1521-7035 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66896820 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animals Anti-tumor activity B16F10 melanoma Biological and medical sciences Cell Line, Tumor Dendritic Cells - immunology Dermatology Female Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Galectin-9 Galectins - metabolism Galectins - pharmacology Killer Cells, Natural - immunology Lymphocyte Activation Macrophage Macrophages - drug effects Macrophages - immunology Medical sciences Mice Mice, Inbred C57BL Neoplasms - immunology NK cell Phenotype Plasmacytoid dendritic cell Time Factors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T12%3A23%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Galectin-9%20expands%20unique%20macrophages%20exhibiting%20plasmacytoid%20dendritic%20cell-like%20phenotypes%20that%20activate%20NK%20cells%20in%20tumor-bearing%20mice&rft.jtitle=Clinical%20immunology%20(Orlando,%20Fla.)&rft.au=Nobumoto,%20Atsuya&rft.date=2009-03-01&rft.volume=130&rft.issue=3&rft.spage=322&rft.epage=330&rft.pages=322-330&rft.issn=1521-6616&rft.eissn=1521-7035&rft.coden=CLIIFY&rft_id=info:doi/10.1016/j.clim.2008.09.014&rft_dat=%3Cproquest_cross%3E20357759%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20357759&rft_id=info:pmid/18974023&rft_els_id=S1521661608008310&rfr_iscdi=true |