Green tea: prevention and treatment of cancer by nutraceuticals
Green tea1 has always been considered by the Chinese and Japanese peoples as a potent medicine for the maintenance of health, endowed with the power to prolong life. Recently, Yean Lee and colleagues' looked at the effects of the main active green tea constituent, epigallocatechin-3-gallate (EG...
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| Veröffentlicht in: | The Lancet (British edition) 2004-09, Vol.364 (9439), p.1021-1022 |
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| creator | Béliveau, Richard Gingras, Denis |
| description | Green tea1 has always been considered by the Chinese and Japanese peoples as a potent medicine for the maintenance of health, endowed with the power to prolong life. Recently, Yean Lee and colleagues' looked at the effects of the main active green tea constituent, epigallocatechin-3-gallate (EGCG) on chronic lymphocytic leukaemia B cells isolated from leukaemic patients. These cells are characterised by their resistance to apoptosis because they secrete and bind vascular endothelial growth factor (VEGF), a potent angiogenic cytokine that also acts as a crucial survival factor for tumour cells. The researchers showed that addition of EGCG to these cells markedly decreased VEGF-receptor phosphorylation, leading to the disruption of the VEGF-dependent autocrine pathway that protects the cells from apoptosis and cell death. |
| doi_str_mv | 10.1016/S0140-6736(04)17076-1 |
| format | Article |
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Recently, Yean Lee and colleagues' looked at the effects of the main active green tea constituent, epigallocatechin-3-gallate (EGCG) on chronic lymphocytic leukaemia B cells isolated from leukaemic patients. These cells are characterised by their resistance to apoptosis because they secrete and bind vascular endothelial growth factor (VEGF), a potent angiogenic cytokine that also acts as a crucial survival factor for tumour cells. The researchers showed that addition of EGCG to these cells markedly decreased VEGF-receptor phosphorylation, leading to the disruption of the VEGF-dependent autocrine pathway that protects the cells from apoptosis and cell death.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(04)17076-1</identifier><identifier>PMID: 15380952</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antineoplastic Agents, Phytogenic - therapeutic use ; Apoptosis - drug effects ; Cancer ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Catechin - therapeutic use ; Folk medicine ; Functional foods & nutraceuticals ; Green tea ; Humans ; Leukemia ; Leukemia, B-Cell - drug therapy ; Medical research ; Medical treatment ; Neoplasms - prevention & control ; Phytotherapy ; Plant Extracts - therapeutic use ; Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors ; Tea ; Tea - chemistry ; Toxicity</subject><ispartof>The Lancet (British edition), 2004-09, Vol.364 (9439), p.1021-1022</ispartof><rights>2004 Elsevier Ltd</rights><rights>Copyright Lancet Ltd. 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Recently, Yean Lee and colleagues' looked at the effects of the main active green tea constituent, epigallocatechin-3-gallate (EGCG) on chronic lymphocytic leukaemia B cells isolated from leukaemic patients. These cells are characterised by their resistance to apoptosis because they secrete and bind vascular endothelial growth factor (VEGF), a potent angiogenic cytokine that also acts as a crucial survival factor for tumour cells. The researchers showed that addition of EGCG to these cells markedly decreased VEGF-receptor phosphorylation, leading to the disruption of the VEGF-dependent autocrine pathway that protects the cells from apoptosis and cell death.</description><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Apoptosis - drug effects</subject><subject>Cancer</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Catechin - therapeutic use</subject><subject>Folk medicine</subject><subject>Functional foods & nutraceuticals</subject><subject>Green tea</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, B-Cell - drug therapy</subject><subject>Medical research</subject><subject>Medical treatment</subject><subject>Neoplasms - prevention & control</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors</subject><subject>Tea</subject><subject>Tea - 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Recently, Yean Lee and colleagues' looked at the effects of the main active green tea constituent, epigallocatechin-3-gallate (EGCG) on chronic lymphocytic leukaemia B cells isolated from leukaemic patients. These cells are characterised by their resistance to apoptosis because they secrete and bind vascular endothelial growth factor (VEGF), a potent angiogenic cytokine that also acts as a crucial survival factor for tumour cells. The researchers showed that addition of EGCG to these cells markedly decreased VEGF-receptor phosphorylation, leading to the disruption of the VEGF-dependent autocrine pathway that protects the cells from apoptosis and cell death.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15380952</pmid><doi>10.1016/S0140-6736(04)17076-1</doi><tpages>2</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 2004-09, Vol.364 (9439), p.1021-1022 |
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| language | eng |
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| subjects | Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis - drug effects Cancer Catechin - analogs & derivatives Catechin - pharmacology Catechin - therapeutic use Folk medicine Functional foods & nutraceuticals Green tea Humans Leukemia Leukemia, B-Cell - drug therapy Medical research Medical treatment Neoplasms - prevention & control Phytotherapy Plant Extracts - therapeutic use Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Tea Tea - chemistry Toxicity |
| title | Green tea: prevention and treatment of cancer by nutraceuticals |
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