Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia

To study the hierarchical levels of stem cell targets for ABL-kinase domain mutations in CML, highly purified CD34+CD38− and CD34+CD38+ cell populations and their LTC-IC-derived progeny were analyzed in four patients at diagnosis (n=1) or in advanced phases (n=3) of their disease. In the single pati...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-10, Vol.323 (3), p.728-730
Hauptverfasser:	Sorel, N., Bonnet, M.L., Guillier, M., Guilhot, F., Brizard, A., Turhan, A.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABL-kinase domain mutations Antineoplastic Agents - administration & dosage BCR-ABL Benzamides Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Chronic myelogenous leukemia Drug Resistance - genetics Enzyme Inhibitors - administration & dosage Fusion Proteins, bcr-abl - genetics Gene Expression Regulation, Neoplastic - drug effects Genetic Predisposition to Disease - genetics Genetic Testing - methods Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Mutation Phosphotransferases - antagonists & inhibitors Phosphotransferases - genetics Piperazines - administration & dosage Protein Structure, Tertiary Pyrimidines - administration & dosage Sequence Analysis, Protein Stem cells Stem Cells - drug effects Stem Cells - enzymology Stem Cells - pathology Structure-Activity Relationship Tumor Cells, Cultured Tyrosine kinase
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