Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress

Mitochondria are both targets and sources of oxidative stress. This dual relationship is particularly evident in experimental paradigms modeling ischemic brain injury. One mitochondrial metabolic enzyme that is particularly sensitive to oxidative inactivation is pyruvate dehydrogenase. This reaction...

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Veröffentlicht in:	Journal of bioenergetics and biomembranes 2004-08, Vol.36 (4), p.347-352
Hauptverfasser:	Fiskum, Gary, Rosenthal, Robert E, Vereczki, Viktoria, Martin, Erica, Hoffman, Gloria E, Chinopoulos, Christos, Kowaltowski, Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Apoptosis Brain - metabolism Brain damage Brain Ischemia - metabolism Brain Ischemia - prevention & control Calcium - metabolism Cell Hypoxia - drug effects Cell Respiration Enzymes Gene expression Humans Inactivation Lipids Mitochondria Mitochondria - metabolism Mitochondrial Proteins - metabolism Models, Biological Neurons - metabolism Neuroprotective Agents - pharmacology Oxidative stress Oxidative Stress - drug effects Oxygen Pyruvate Dehydrogenase Complex - metabolism Reactive Oxygen Species - metabolism Signal Transduction - drug effects
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