Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus
CXC-chemokine receptor 4 (CXCR4) functions as a receptor for feline immunodeficiency virus (FIV). Although we previously found that a CXCR4 antagonist, T140, inhibited the FIV replication in vitro, it was not effective in cats infected with FIV because of its low stability in feline serum. To resolv...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2009, Vol.71(1), pp.121-124 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Mizukoshi, F.(Tokyo Univ. (Japan)) Baba, K Goto Koshino, Y Setoguchi Mukai, A Fujino, Y Ohno, K Tamamura, H Oishi, S Fujii, N Tsujimoto, H |
| description | CXC-chemokine receptor 4 (CXCR4) functions as a receptor for feline immunodeficiency virus (FIV). Although we previously found that a CXCR4 antagonist, T140, inhibited the FIV replication in vitro, it was not effective in cats infected with FIV because of its low stability in feline serum. To resolve this problem, several T140 derivatives have been developed. Here, we examined the efficacy of T140 analogs, TF14016 and TF14013, on the inhibition of FIV infection. These compounds were shown to significantly inhibit the syncytia formation in CXCR4-expressing cells after co-cultivation with FIV-infected cells and the replication of FIV in a feline lymphoid cultured cell line. These results indicated that TF14016 and TF14013 could be useful as antiviral drugs for cats infected with FIV. |
| doi_str_mv | 10.1292/jvms.71.121 |
| format | Article |
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(Japan)) ; Baba, K ; Goto Koshino, Y ; Setoguchi Mukai, A ; Fujino, Y ; Ohno, K ; Tamamura, H ; Oishi, S ; Fujii, N ; Tsujimoto, H</creator><creatorcontrib>Mizukoshi, F.(Tokyo Univ. (Japan)) ; Baba, K ; Goto Koshino, Y ; Setoguchi Mukai, A ; Fujino, Y ; Ohno, K ; Tamamura, H ; Oishi, S ; Fujii, N ; Tsujimoto, H</creatorcontrib><description>CXC-chemokine receptor 4 (CXCR4) functions as a receptor for feline immunodeficiency virus (FIV). Although we previously found that a CXCR4 antagonist, T140, inhibited the FIV replication in vitro, it was not effective in cats infected with FIV because of its low stability in feline serum. To resolve this problem, several T140 derivatives have been developed. Here, we examined the efficacy of T140 analogs, TF14016 and TF14013, on the inhibition of FIV infection. These compounds were shown to significantly inhibit the syncytia formation in CXCR4-expressing cells after co-cultivation with FIV-infected cells and the replication of FIV in a feline lymphoid cultured cell line. These results indicated that TF14016 and TF14013 could be useful as antiviral drugs for cats infected with FIV.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.71.121</identifier><identifier>PMID: 19194089</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; ANTAGONISM ; ANTAGONISME ; ANTAGONISMO ; Cat Diseases - prevention & control ; CATS ; CHAT ; CXCR4 antagonist ; feline ; Feline immunodeficiency virus ; FIV ; Flow Cytometry ; GATO ; HeLa Cells ; Humans ; IMMUNODEFICIENCE ; IMMUNODEFICIENCY ; Immunodeficiency Virus, Feline - immunology ; INFECCION ; INFECTION ; INMUNODEFICIENCIA ; Lentivirus Infections - prevention & control ; Lentivirus Infections - veterinary ; Oligopeptides - pharmacology ; Peptides - physiology ; Receptors, CXCR4 - antagonists & inhibitors ; VIRUS ; Virus Replication - drug effects ; VIRUSES</subject><ispartof>Journal of Veterinary Medical Science, 2009, Vol.71(1), pp.121-124</ispartof><rights>2009 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-2d8274caf0965f81b9a01a93c8d1d5fc96ef6aaf6019d228e48bceadff4d577c3</citedby><cites>FETCH-LOGICAL-c486t-2d8274caf0965f81b9a01a93c8d1d5fc96ef6aaf6019d228e48bceadff4d577c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19194089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizukoshi, F.(Tokyo Univ. 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To resolve this problem, several T140 derivatives have been developed. Here, we examined the efficacy of T140 analogs, TF14016 and TF14013, on the inhibition of FIV infection. These compounds were shown to significantly inhibit the syncytia formation in CXCR4-expressing cells after co-cultivation with FIV-infected cells and the replication of FIV in a feline lymphoid cultured cell line. These results indicated that TF14016 and TF14013 could be useful as antiviral drugs for cats infected with FIV.</description><subject>Animals</subject><subject>ANTAGONISM</subject><subject>ANTAGONISME</subject><subject>ANTAGONISMO</subject><subject>Cat Diseases - prevention & control</subject><subject>CATS</subject><subject>CHAT</subject><subject>CXCR4 antagonist</subject><subject>feline</subject><subject>Feline immunodeficiency virus</subject><subject>FIV</subject><subject>Flow Cytometry</subject><subject>GATO</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>IMMUNODEFICIENCE</subject><subject>IMMUNODEFICIENCY</subject><subject>Immunodeficiency Virus, Feline - immunology</subject><subject>INFECCION</subject><subject>INFECTION</subject><subject>INMUNODEFICIENCIA</subject><subject>Lentivirus Infections - prevention & control</subject><subject>Lentivirus Infections - veterinary</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptides - physiology</subject><subject>Receptors, CXCR4 - antagonists & inhibitors</subject><subject>VIRUS</subject><subject>Virus Replication - drug effects</subject><subject>VIRUSES</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFrFDEUh4Modls9eVYCgheZmmQyk-SmLFYrBT0oeAvZzEs360yyJjNb9uD_boZZWvAihIQf-d4HeS8IvaDkkjLF3u0OQ74UtAT6CK1ozUUleK0eoxVRtK0Ea8gZOs95RwijvFVP0RlVVHEi1Qr9uQ5bv_FjTEcMzoEdcXQ4wF1_xB0coI976PD657qyWxjiLx8AJ7CwLxWYYxNGcxuDz2PGMeBxC9iH2eJLuvPjFjvo5xo_DFOIHThvPQR7xAefpvwMPXGmz_D8dF6gH1cfv68_VzdfP12vP9xUlst2rFgnmeDWOKLaxkm6UYZQo2orO9o1zqoWXGuMawlVHWMSuNxYMJ1zvGuEsPUFerN49yn-niCPevDZQt-bAHHKum2lqsv6L8gIF1JyWsDX_4C7OKVQHqFLj6WgjSCqUG8XyqaYcwKn98kPJh01JXoenp6HpwUtYXa-OjmnzQDdA3uaVgHeL8Aul7bDPWDS6G0PD7JlK877K7s1SUMoipeLwpmozW3yWX_5xghR8-eQdf0X4ui4FQ</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Mizukoshi, F.(Tokyo Univ. 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| subjects | Animals ANTAGONISM ANTAGONISME ANTAGONISMO Cat Diseases - prevention & control CATS CHAT CXCR4 antagonist feline Feline immunodeficiency virus FIV Flow Cytometry GATO HeLa Cells Humans IMMUNODEFICIENCE IMMUNODEFICIENCY Immunodeficiency Virus, Feline - immunology INFECCION INFECTION INMUNODEFICIENCIA Lentivirus Infections - prevention & control Lentivirus Infections - veterinary Oligopeptides - pharmacology Peptides - physiology Receptors, CXCR4 - antagonists & inhibitors VIRUS Virus Replication - drug effects VIRUSES |
| title | Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus |
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