Energetic and Hydration Contributions of the Removal of Methyl Groups From Thymine to Form Uracil in G-Quadruplexes

A combination of spectroscopic and calorimetric techniques is used to investigate the unfolding of two G-quadruplexes: d(G2U2G2UGUG2U2G2), G2-U, and d(G2T2G2TGTG2T2G2), G2. The comparisons of their thermodynamic data allow us to elucidate the role of methylation on the energetic and hydration proper...

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Veröffentlicht in:	The journal of physical chemistry. B 2009-01, Vol.113 (1), p.9-11
Hauptverfasser:	Olsen, Chris M, Marky, Luis A
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry G-Quadruplexes Methylation Thermodynamics Thymine - chemistry Uracil - chemistry
Online-Zugang:	Volltext
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