In vitro and in vivo expansion of hematopoietic stem cells
The capacity for sustained self-renewal – the generation of daughter cells having the same regenerative properties as the parent cell – is the defining feature of hematopoietic stem cells (HSCs). Strong evidence exists that self-renewal of HSC is under extrinsic biological control in vivo . A variet...
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| Veröffentlicht in: | Oncogene 2004-09, Vol.23 (43), p.7223-7232 |
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| container_title | Oncogene |
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| creator | Sauvageau, Guy Iscove, Norman N Humphries, R Keith |
| description | The capacity for sustained self-renewal – the generation of daughter cells having the same regenerative properties as the parent cell – is the defining feature of hematopoietic stem cells (HSCs). Strong evidence exists that self-renewal of HSC is under extrinsic biological control
in vivo
. A variety of cytokines, morphogenic ligands and associated signaling components influence self-renewal in culture and
in vivo
. Specific homeobox transcription factors act as powerful intrinsic agonists of HSC self-renewal
in vitro
and
in vivo
when supplied either as transduced cDNAs or as externally delivered proteins. These findings provide tools for deepening our knowledge of mechanism and for achievement of clinically useful levels of HSC expansion. |
| doi_str_mv | 10.1038/sj.onc.1207942 |
| format | Article |
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in vivo
. A variety of cytokines, morphogenic ligands and associated signaling components influence self-renewal in culture and
in vivo
. Specific homeobox transcription factors act as powerful intrinsic agonists of HSC self-renewal
in vitro
and
in vivo
when supplied either as transduced cDNAs or as externally delivered proteins. These findings provide tools for deepening our knowledge of mechanism and for achievement of clinically useful levels of HSC expansion.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1207942</identifier><identifier>PMID: 15378082</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Apoptosis ; Biological control ; Cancer ; Cell Biology ; Cell culture ; Cell Division - drug effects ; Cell self-renewal ; Cells, Cultured - cytology ; Cells, Cultured - drug effects ; Cytokines ; DNA, Complementary - genetics ; Gene Expression Regulation, Developmental ; Genes, Homeobox ; Growth factors ; Hematopoietic Cell Growth Factors - pharmacology ; Hematopoietic Cell Growth Factors - physiology ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - drug effects ; Homeobox ; Homeodomain Proteins - genetics ; Homeodomain Proteins - pharmacology ; Homeodomain Proteins - physiology ; Human Genetics ; Humans ; Immunology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mice ; Oncology ; Recombinant Fusion Proteins - physiology ; review ; Stem cells ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - pharmacology ; Transcription Factors - physiology</subject><ispartof>Oncogene, 2004-09, Vol.23 (43), p.7223-7232</ispartof><rights>Springer Nature Limited 2004</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 20, 2004</rights><rights>Nature Publishing Group 2004.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-bc3d0fc81abd5b46ed025faf503a9431ef1c84731936477526e3584e93f1dbe33</citedby><cites>FETCH-LOGICAL-c590t-bc3d0fc81abd5b46ed025faf503a9431ef1c84731936477526e3584e93f1dbe33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1207942$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1207942$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15378082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauvageau, Guy</creatorcontrib><creatorcontrib>Iscove, Norman N</creatorcontrib><creatorcontrib>Humphries, R Keith</creatorcontrib><title>In vitro and in vivo expansion of hematopoietic stem cells</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>The capacity for sustained self-renewal – the generation of daughter cells having the same regenerative properties as the parent cell – is the defining feature of hematopoietic stem cells (HSCs). Strong evidence exists that self-renewal of HSC is under extrinsic biological control
in vivo
. A variety of cytokines, morphogenic ligands and associated signaling components influence self-renewal in culture and
in vivo
. Specific homeobox transcription factors act as powerful intrinsic agonists of HSC self-renewal
in vitro
and
in vivo
when supplied either as transduced cDNAs or as externally delivered proteins. These findings provide tools for deepening our knowledge of mechanism and for achievement of clinically useful levels of HSC expansion.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological control</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Cell Division - drug effects</subject><subject>Cell self-renewal</subject><subject>Cells, Cultured - cytology</subject><subject>Cells, Cultured - drug effects</subject><subject>Cytokines</subject><subject>DNA, Complementary - genetics</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Homeobox</subject><subject>Growth factors</subject><subject>Hematopoietic Cell Growth Factors - pharmacology</subject><subject>Hematopoietic Cell Growth Factors - physiology</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Homeobox</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - pharmacology</subject><subject>Homeodomain Proteins - physiology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Oncology</subject><subject>Recombinant Fusion Proteins - physiology</subject><subject>review</subject><subject>Stem cells</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - pharmacology</subject><subject>Transcription Factors - physiology</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc9LHDEcxUOp1K3t1aMMLXibNb8n8SZSW0Hw0p5DJvONZtlJ1mRW9L83gwsLopQcQpLP9-U9HkLHBC8JZuqsrJYpuiWhuNOcfkILwjvZCqH5Z7TAWuBWU0YP0ddSVhhXCNMv6JAI1ims6AKdX8fmMUw5NTYOTZgPj6mBp42NJaTYJN_cw2intEkBpuCaMsHYOFivyzd04O26wPfdfoT-Xf36e_mnvbn9fX15cdM6ofHU9o4N2DtFbD-InksYMBXeeoGZ1ZwR8MQp3jGimeRdJ6gEJhQHzTwZemDsCJ2-6m5yethCmcwYyuzARkjbYqRUmuoa6X8gUVgK1ckK_nwDrtI2xxrCUMkJY7pilfrxIUW76lFovZe6s2swIfo0Zevmf80FURprrdTsbPkOVdcAY3Apgg_1_r0Bl1MpGbzZ5DDa_GwINnPxpqxMLd7siq8DJzuz236EYY_vmq7A2StQ6lO8g7xP84HkC8k1tao</recordid><startdate>20040920</startdate><enddate>20040920</enddate><creator>Sauvageau, Guy</creator><creator>Iscove, Norman N</creator><creator>Humphries, R Keith</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040920</creationdate><title>In vitro and in vivo expansion of hematopoietic stem cells</title><author>Sauvageau, Guy ; Iscove, Norman N ; Humphries, R Keith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-bc3d0fc81abd5b46ed025faf503a9431ef1c84731936477526e3584e93f1dbe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological control</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell culture</topic><topic>Cell Division - drug effects</topic><topic>Cell self-renewal</topic><topic>Cells, Cultured - cytology</topic><topic>Cells, Cultured - drug effects</topic><topic>Cytokines</topic><topic>DNA, Complementary - genetics</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Homeobox</topic><topic>Growth factors</topic><topic>Hematopoietic Cell Growth Factors - pharmacology</topic><topic>Hematopoietic Cell Growth Factors - physiology</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Homeobox</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - pharmacology</topic><topic>Homeodomain Proteins - physiology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Oncology</topic><topic>Recombinant Fusion Proteins - 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Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauvageau, Guy</au><au>Iscove, Norman N</au><au>Humphries, R Keith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo expansion of hematopoietic stem cells</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2004-09-20</date><risdate>2004</risdate><volume>23</volume><issue>43</issue><spage>7223</spage><epage>7232</epage><pages>7223-7232</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>The capacity for sustained self-renewal – the generation of daughter cells having the same regenerative properties as the parent cell – is the defining feature of hematopoietic stem cells (HSCs). Strong evidence exists that self-renewal of HSC is under extrinsic biological control
in vivo
. A variety of cytokines, morphogenic ligands and associated signaling components influence self-renewal in culture and
in vivo
. Specific homeobox transcription factors act as powerful intrinsic agonists of HSC self-renewal
in vitro
and
in vivo
when supplied either as transduced cDNAs or as externally delivered proteins. These findings provide tools for deepening our knowledge of mechanism and for achievement of clinically useful levels of HSC expansion.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15378082</pmid><doi>10.1038/sj.onc.1207942</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 2004-09, Vol.23 (43), p.7223-7232 |
| issn | 0950-9232 1476-5594 |
| language | eng |
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| source | MEDLINE; Nature; EZB Electronic Journals Library; SpringerLink Journals - AutoHoldings |
| subjects | Animals Apoptosis Biological control Cancer Cell Biology Cell culture Cell Division - drug effects Cell self-renewal Cells, Cultured - cytology Cells, Cultured - drug effects Cytokines DNA, Complementary - genetics Gene Expression Regulation, Developmental Genes, Homeobox Growth factors Hematopoietic Cell Growth Factors - pharmacology Hematopoietic Cell Growth Factors - physiology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - pharmacology Homeodomain Proteins - physiology Human Genetics Humans Immunology Internal Medicine Medicine Medicine & Public Health Mice Oncology Recombinant Fusion Proteins - physiology review Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - pharmacology Transcription Factors - physiology |
| title | In vitro and in vivo expansion of hematopoietic stem cells |
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