Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation
Partial nerve injury results in chronic pain that is difficult to treat effectively. To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin–horseradish peroxidase (WGA‐HRP) to label the central projections of uninjured small fibers (Aδ and C) in a well‐established model o...
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| Veröffentlicht in: | The European journal of neuroscience 2004-10, Vol.20 (7), p.1705-1712 |
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| container_title | The European journal of neuroscience |
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| creator | Hu, Jian Mata, Marina Hao, Shuanglin Zhang, Gui Fink, David J. |
| description | Partial nerve injury results in chronic pain that is difficult to treat effectively. To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin–horseradish peroxidase (WGA‐HRP) to label the central projections of uninjured small fibers (Aδ and C) in a well‐established model of neuropathic pain created by selective spinal nerve ligation in the adult. We found extensive sprouting of uninjured WGA‐HRP‐labeled afferents into the central termination field in lamina II of dorsal horn normally occupied by L5 afferents whose peripheral axons had been ligated distal to the dorsal root ganglion. The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain. |
| doi_str_mv | 10.1111/j.1460-9568.2004.03652.x |
| format | Article |
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To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin–horseradish peroxidase (WGA‐HRP) to label the central projections of uninjured small fibers (Aδ and C) in a well‐established model of neuropathic pain created by selective spinal nerve ligation in the adult. We found extensive sprouting of uninjured WGA‐HRP‐labeled afferents into the central termination field in lamina II of dorsal horn normally occupied by L5 afferents whose peripheral axons had been ligated distal to the dorsal root ganglion. The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain.</description><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Axonal Transport</subject><subject>Hyperalgesia - physiopathology</subject><subject>Male</subject><subject>Nerve Fibers - physiology</subject><subject>neural plasticity</subject><subject>neuropathic</subject><subject>pain</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spinal Cord - physiopathology</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>spinal nerve ligation</subject><subject>sprouting</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0EokvhLyCfuCWM7cRODhzQUhZKVSQEgpvlOOPixZu0dkK3_x6nuypH8MUe-33PmnmEUAYly-v1tmSVhKKtZVNygKoEIWte7h-R1cPDY7KCthZFw-SPE_IspS0ANLKqn5ITVgvVti1bkZs1DlM0gabrOM6TH67o6Og8-GE7R-xp2pkQqPMdRmqcw5jlifqBTj-Rmn4OE41myrQfsokdY0_dGMJ4uzgdbweMv5EGf2UmPw7PyRNnQsIXx_2UfHt_9nX9obj4vPm4fntR2BqAF5xbtLxnDMChBAkOQFW8BaPAdrnsFG9sjY3FjtvOCu6khUY5rkTX9604Ja8OvrmxmxnTpHc-WQzBDDjOSUvZtLwC9U8hU0IIxussbA5CG8eUIjp9Hf3OxDvNQC-56K1exq-X8eslF32fi95n9OXxj7nbYf8XPAaRBW8Oglsf8O6_jfXZ-eVyynxx4H2acP_Am_hLSyVUrb9fbjR7xz7lVr7ojfgDGKKssQ</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Hu, Jian</creator><creator>Mata, Marina</creator><creator>Hao, Shuanglin</creator><creator>Zhang, Gui</creator><creator>Fink, David J.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation</title><author>Hu, Jian ; Mata, Marina ; Hao, Shuanglin ; Zhang, Gui ; Fink, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5002-22cec2d1100fe6060f0074290a70cb60fb728c5e8ceb2cbc32f6c087f273bdd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Axonal Transport</topic><topic>Hyperalgesia - physiopathology</topic><topic>Male</topic><topic>Nerve Fibers - physiology</topic><topic>neural plasticity</topic><topic>neuropathic</topic><topic>pain</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spinal Cord - physiopathology</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>spinal nerve ligation</topic><topic>sprouting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Jian</creatorcontrib><creatorcontrib>Mata, Marina</creatorcontrib><creatorcontrib>Hao, Shuanglin</creatorcontrib><creatorcontrib>Zhang, Gui</creatorcontrib><creatorcontrib>Fink, David J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Jian</au><au>Mata, Marina</au><au>Hao, Shuanglin</au><au>Zhang, Gui</au><au>Fink, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2004-10</date><risdate>2004</risdate><volume>20</volume><issue>7</issue><spage>1705</spage><epage>1712</epage><pages>1705-1712</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Partial nerve injury results in chronic pain that is difficult to treat effectively. 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| ispartof | The European journal of neuroscience, 2004-10, Vol.20 (7), p.1705-1712 |
| issn | 0953-816X 1460-9568 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Afferent Pathways - physiology Animals Axonal Transport Hyperalgesia - physiopathology Male Nerve Fibers - physiology neural plasticity neuropathic pain Rats Rats, Sprague-Dawley Spinal Cord - physiopathology Spinal Cord Injuries - physiopathology spinal nerve ligation sprouting |
| title | Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation |
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