Overexpression of beta2-adrenergic receptors cAMP-dependent protein kinase phosphorylates and modulates slow delayed rectifier potassium channels expressed in murine heart: evidence for receptor/channel co-localization

The cardiac slow delayed rectifier potassium channel (IKs), comprised of (KCNQ1) and beta (KCNE1) subunits, is regulated by sympathetic nervous stimulation, with activation of beta-adrenergic receptors PKA phosphorylating IKs channels. We examined the effects of 2-adrenergic receptors (beta2-AR) on...

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Veröffentlicht in:	The Journal of biological chemistry 2004-09, Vol.279 (39), p.40778-40787
Hauptverfasser:	Dilly, Keith W, Kurokawa, Junko, Terrenoire, Cecile, Reiken, Steven, Lederer, W J, Marks, Andrew R, Kass, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calcium Channels - chemistry Cells, Cultured Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Electrophysiology Fluorescence Resonance Energy Transfer Heart Ventricles - metabolism Immunohistochemistry KCNQ Potassium Channels KCNQ1 Potassium Channel Mice Mice, Transgenic Microscopy, Fluorescence Myocytes, Cardiac - metabolism Phosphorylation Potassium Channels - biosynthesis Potassium Channels - metabolism Potassium Channels, Voltage-Gated Precipitin Tests Receptors, Adrenergic, beta-2 - biosynthesis Up-Regulation
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