Coexistence of corticotroph adenoma and thyrotroph hyperplasia in a dog
Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's dis...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2009, Vol.71(1), pp.93-98 |
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| creator | Teshima, T.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). Faculty of Veterinary Medicine) Hara, Y Shigihara, K Takekoshi, S Nezu, Y Harada, Y Yogo, T Teramoto, A Osamura, R.Y Tagawa, M |
| description | Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia. |
| doi_str_mv | 10.1292/jvms.71.93 |
| format | Article |
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Faculty of Veterinary Medicine) ; Hara, Y ; Shigihara, K ; Takekoshi, S ; Nezu, Y ; Harada, Y ; Yogo, T ; Teramoto, A ; Osamura, R.Y ; Tagawa, M</creator><creatorcontrib>Teshima, T.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). Faculty of Veterinary Medicine) ; Hara, Y ; Shigihara, K ; Takekoshi, S ; Nezu, Y ; Harada, Y ; Yogo, T ; Teramoto, A ; Osamura, R.Y ; Tagawa, M</creatorcontrib><description>Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.71.93</identifier><identifier>PMID: 19194082</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>ACTH-Secreting Pituitary Adenoma - complications ; ACTH-Secreting Pituitary Adenoma - pathology ; ACTH-Secreting Pituitary Adenoma - veterinary ; ADENOMA ; Adenoma - complications ; Adenoma - pathology ; Adenoma - veterinary ; ADENOME ; ADRENAL GLANDS ; Animals ; canine ; CHIEN ; corticotroph adenoma ; Cushing's disease ; Dog Diseases - pathology ; DOGS ; ENDOCRINE DISEASES ; ENFERMEDADES GLANDULAS ENDOCRINAS ; GLANDULA PITUITARIA ; GLANDULAS SUPRARRENALES ; HIPERPLASIA ; HYPERPLASIA ; Hyperplasia - complications ; Hyperplasia - pathology ; Hyperplasia - veterinary ; HYPERPLASIE ; HYPOPHYSE ; Immunohistochemistry - veterinary ; Male ; PERRO ; pituitary ; Pituitary ACTH Hypersecretion - complications ; Pituitary ACTH Hypersecretion - veterinary ; PITUITARY GLAND ; SURRENALE ; thyrotroph hyperplasia ; Thyrotrophs - pathology ; TROUBLE ENDOCRINIEN</subject><ispartof>Journal of Veterinary Medical Science, 2009, Vol.71(1), pp.93-98</ispartof><rights>2009 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-ceb3f745d82c85d646205a0e118191a95574910b49a886fcccb629750edf78ba3</citedby><cites>FETCH-LOGICAL-c583t-ceb3f745d82c85d646205a0e118191a95574910b49a886fcccb629750edf78ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19194082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teshima, T.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). Faculty of Veterinary Medicine)</creatorcontrib><creatorcontrib>Hara, Y</creatorcontrib><creatorcontrib>Shigihara, K</creatorcontrib><creatorcontrib>Takekoshi, S</creatorcontrib><creatorcontrib>Nezu, Y</creatorcontrib><creatorcontrib>Harada, Y</creatorcontrib><creatorcontrib>Yogo, T</creatorcontrib><creatorcontrib>Teramoto, A</creatorcontrib><creatorcontrib>Osamura, R.Y</creatorcontrib><creatorcontrib>Tagawa, M</creatorcontrib><title>Coexistence of corticotroph adenoma and thyrotroph hyperplasia in a dog</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia.</description><subject>ACTH-Secreting Pituitary Adenoma - complications</subject><subject>ACTH-Secreting Pituitary Adenoma - pathology</subject><subject>ACTH-Secreting Pituitary Adenoma - veterinary</subject><subject>ADENOMA</subject><subject>Adenoma - complications</subject><subject>Adenoma - pathology</subject><subject>Adenoma - veterinary</subject><subject>ADENOME</subject><subject>ADRENAL GLANDS</subject><subject>Animals</subject><subject>canine</subject><subject>CHIEN</subject><subject>corticotroph adenoma</subject><subject>Cushing's disease</subject><subject>Dog Diseases - pathology</subject><subject>DOGS</subject><subject>ENDOCRINE DISEASES</subject><subject>ENFERMEDADES GLANDULAS ENDOCRINAS</subject><subject>GLANDULA PITUITARIA</subject><subject>GLANDULAS SUPRARRENALES</subject><subject>HIPERPLASIA</subject><subject>HYPERPLASIA</subject><subject>Hyperplasia - complications</subject><subject>Hyperplasia - pathology</subject><subject>Hyperplasia - veterinary</subject><subject>HYPERPLASIE</subject><subject>HYPOPHYSE</subject><subject>Immunohistochemistry - veterinary</subject><subject>Male</subject><subject>PERRO</subject><subject>pituitary</subject><subject>Pituitary ACTH Hypersecretion - complications</subject><subject>Pituitary ACTH Hypersecretion - veterinary</subject><subject>PITUITARY GLAND</subject><subject>SURRENALE</subject><subject>thyrotroph hyperplasia</subject><subject>Thyrotrophs - pathology</subject><subject>TROUBLE ENDOCRINIEN</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1r2zAYh8VoWbNul91XDIUdCs70_XEaI2xtR2E7bGfxWpYTB9tyJac0__0UHDLopRcJ9D486P39EPpI8JJQQ79sn_q0VGRp2Bu0IIyrUnFmztACGyJLRQW-QO9S2mJMCZfmLboghhiONV2g21Xwz22a_OB8EZrChTi1LkwxjJsCaj-EHgoY6mLa7OPxebMffRw7SC0U7VBAUYf1e3TeQJf8h-N9if7--P5ndVc-_Lq9X317KJ3QbCqdr1ijuKg1dVrUkkuKBWBPiM5_AiOE4obgihvQWjbOuUpSowT2daN0BewSfZ69YwyPO58m27fJ-a6DwYddslLqvLTRr4IUc6UUxxm8fgFuwy4OeQmb09KKCEVopm5mysWQUvSNHWPbQ9xbgu2hBXtowSpiDcvw1VG5q3pf_0ePsWfg6wxs0wRrfwLgEH7nTy4yH4adJm4D0fohGz7NhgaChXVsk_35m2JsDiUryf4BTxWh8w</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Teshima, T.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). 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Faculty of Veterinary Medicine) ; Hara, Y ; Shigihara, K ; Takekoshi, S ; Nezu, Y ; Harada, Y ; Yogo, T ; Teramoto, A ; Osamura, R.Y ; Tagawa, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-ceb3f745d82c85d646205a0e118191a95574910b49a886fcccb629750edf78ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>ACTH-Secreting Pituitary Adenoma - complications</topic><topic>ACTH-Secreting Pituitary Adenoma - pathology</topic><topic>ACTH-Secreting Pituitary Adenoma - veterinary</topic><topic>ADENOMA</topic><topic>Adenoma - complications</topic><topic>Adenoma - pathology</topic><topic>Adenoma - veterinary</topic><topic>ADENOME</topic><topic>ADRENAL GLANDS</topic><topic>Animals</topic><topic>canine</topic><topic>CHIEN</topic><topic>corticotroph adenoma</topic><topic>Cushing's disease</topic><topic>Dog Diseases - pathology</topic><topic>DOGS</topic><topic>ENDOCRINE DISEASES</topic><topic>ENFERMEDADES GLANDULAS ENDOCRINAS</topic><topic>GLANDULA PITUITARIA</topic><topic>GLANDULAS SUPRARRENALES</topic><topic>HIPERPLASIA</topic><topic>HYPERPLASIA</topic><topic>Hyperplasia - complications</topic><topic>Hyperplasia - pathology</topic><topic>Hyperplasia - veterinary</topic><topic>HYPERPLASIE</topic><topic>HYPOPHYSE</topic><topic>Immunohistochemistry - veterinary</topic><topic>Male</topic><topic>PERRO</topic><topic>pituitary</topic><topic>Pituitary ACTH Hypersecretion - complications</topic><topic>Pituitary ACTH Hypersecretion - veterinary</topic><topic>PITUITARY GLAND</topic><topic>SURRENALE</topic><topic>thyrotroph hyperplasia</topic><topic>Thyrotrophs - pathology</topic><topic>TROUBLE ENDOCRINIEN</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teshima, T.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). Faculty of Veterinary Medicine)</creatorcontrib><creatorcontrib>Hara, Y</creatorcontrib><creatorcontrib>Shigihara, K</creatorcontrib><creatorcontrib>Takekoshi, S</creatorcontrib><creatorcontrib>Nezu, Y</creatorcontrib><creatorcontrib>Harada, Y</creatorcontrib><creatorcontrib>Yogo, T</creatorcontrib><creatorcontrib>Teramoto, A</creatorcontrib><creatorcontrib>Osamura, R.Y</creatorcontrib><creatorcontrib>Tagawa, M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teshima, T.(Nippon Veterinary and Life Science Univ., Musashino, Tokyo (Japan). Faculty of Veterinary Medicine)</au><au>Hara, Y</au><au>Shigihara, K</au><au>Takekoshi, S</au><au>Nezu, Y</au><au>Harada, Y</au><au>Yogo, T</au><au>Teramoto, A</au><au>Osamura, R.Y</au><au>Tagawa, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coexistence of corticotroph adenoma and thyrotroph hyperplasia in a dog</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>71</volume><issue>1</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>19194082</pmid><doi>10.1292/jvms.71.93</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Veterinary Medical Science, 2009, Vol.71(1), pp.93-98 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | ACTH-Secreting Pituitary Adenoma - complications ACTH-Secreting Pituitary Adenoma - pathology ACTH-Secreting Pituitary Adenoma - veterinary ADENOMA Adenoma - complications Adenoma - pathology Adenoma - veterinary ADENOME ADRENAL GLANDS Animals canine CHIEN corticotroph adenoma Cushing's disease Dog Diseases - pathology DOGS ENDOCRINE DISEASES ENFERMEDADES GLANDULAS ENDOCRINAS GLANDULA PITUITARIA GLANDULAS SUPRARRENALES HIPERPLASIA HYPERPLASIA Hyperplasia - complications Hyperplasia - pathology Hyperplasia - veterinary HYPERPLASIE HYPOPHYSE Immunohistochemistry - veterinary Male PERRO pituitary Pituitary ACTH Hypersecretion - complications Pituitary ACTH Hypersecretion - veterinary PITUITARY GLAND SURRENALE thyrotroph hyperplasia Thyrotrophs - pathology TROUBLE ENDOCRINIEN |
| title | Coexistence of corticotroph adenoma and thyrotroph hyperplasia in a dog |
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