The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors

Circulating endothelial progenitors contribute to neovascularization at sites of injury and tumorigenesis in postnatal life. Yet, the molecular mechanisms initiating the endothelial developmental program of these precursors remain elusive. Here we provide evidence that endothelial development from p...

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Veröffentlicht in:	Blood 2004-10, Vol.104 (7), p.2010-2019
Hauptverfasser:	Hildbrand, Patrick, Cirulli, Vincenzo, Prinsen, Robyn C., Smith, Kent A., Torbett, Bruce E., Salomon, Daniel R., Crisa, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 - biosynthesis Angiopoietin-2 - biosynthesis Antigens, CD34 - biosynthesis Antigens, CD34 - immunology Antigens, CD34 - metabolism Biological and medical sciences Blood vessels and receptors Blotting, Western CD11b Antigen - biosynthesis Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Division Cell physiology Cells, Cultured Collagen - pharmacology DNA, Complementary - metabolism Drug Combinations Endothelial Cells - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fetal Blood - cytology Fetal Blood - metabolism Flow Cytometry Fundamental and applied biological sciences. Psychology Humans Laminin - pharmacology Microscopy, Confocal Molecular and cellular biology Neovascularization, Pathologic Proteoglycans - pharmacology Reverse Transcriptase Polymerase Chain Reaction Stem Cells - cytology Up-Regulation Vertebrates: cardiovascular system
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