The influence of carbon sources on recombinant-human- growth-hormone production by Pichia pastoris is dependent on phenotype: a comparison of Muts and Mut+ strains

The influence of carbon sources on rhGH (recombinant human growth hormone) production by two Pichia pastoris strains having different methanol utilization phenotypes (P. pastoris‐hGH‐Mut+ and P. pastoris‐hGH‐Muts) was investigated using batch bioreactors. The effect of methanol concentration (CMeOH)...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2009-03, Vol.52 (3), p.245-255
Hauptverfasser:	Orman, Mehmet Ali, Çalık, Pınar, Özdamar, Tunçer H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - metabolism AOX1 (alcohol oxidase 1) promoter Biological and medical sciences Biotechnology carbon source Cell Proliferation Fundamental and applied biological sciences. Psychology glycerol Glycerol - metabolism human growth hormone Human Growth Hormone - biosynthesis Human Growth Hormone - genetics methanol Methanol - metabolism Mut+ and Muts Mutation Phenotype Pichia - genetics Pichia - metabolism Pichia pastoris Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Time Factors
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