Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line

Expression of a transmembrane mucin MUC1 is emphasized in most cases of carcinoma. High expression of MUC1 is closely associated with cancer progression and metastasis, leading to poor prognosis. However, little is known about how MUC1 is overexpressed in malignant tumor. In this study, we demonstra...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-02, Vol.379 (4), p.1060-1065
Hauptverfasser:	Mikami, Yuji, Hisatsune, Akinori, Tashiro, Tomomi, Isohama, Yoichiro, Katsuki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Cell Hypoxia - genetics Cell Line, Tumor Cobalt - pharmacology Gene expression Gene Expression Regulation, Neoplastic Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Lung adenocarcinoma cell Lung Neoplasms - genetics MUC1 Mucin-1 - genetics Promoter Regions, Genetic RNA Stability RNA, Messenger - metabolism RNA, Small Interfering - genetics Transcription, Genetic
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