Heroin profiling: mannitol hexaacetate as an unusual ingredient of some illicit drug seizures
Mannitol hexaacetate (MHA) has been detected by GC–MS in some brown illicit drug seizures in which diacetylmorphine (DAM) was completely lacking. The presence of MHA as a genuine ingredient of the drug seizures rather than a storage- or an analytical artifact, formed by transacetylation of mannitol...
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| Veröffentlicht in: | Forensic science international 2004-10, Vol.145 (1), p.41-46 |
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| creator | El-Haj, B.M. Al-Amri, A.M. Ali, H.S. |
| description | Mannitol hexaacetate (MHA) has been detected by GC–MS in some brown illicit drug seizures in which diacetylmorphine (DAM) was completely lacking. The presence of MHA as a genuine ingredient of the drug seizures rather than a storage- or an analytical artifact, formed by transacetylation of mannitol with the DAM in the heroin, has been verified. It is argued that MHA was formed as a result of the addition of mannitol, as diluent, before the acetylating step in the process of the heroin preparation. This early dilution in the production and distribution chain of the illicit drug is deemed as peculiar, nonetheless it may be highly indicative of a specific production process of heroin in a trafficking organization. |
| doi_str_mv | 10.1016/j.forsciint.2004.03.012 |
| format | Article |
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The presence of MHA as a genuine ingredient of the drug seizures rather than a storage- or an analytical artifact, formed by transacetylation of mannitol with the DAM in the heroin, has been verified. It is argued that MHA was formed as a result of the addition of mannitol, as diluent, before the acetylating step in the process of the heroin preparation. This early dilution in the production and distribution chain of the illicit drug is deemed as peculiar, nonetheless it may be highly indicative of a specific production process of heroin in a trafficking organization.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/j.forsciint.2004.03.012</identifier><identifier>PMID: 15374593</identifier><identifier>CODEN: FSINDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Acetates ; Biological and medical sciences ; Brown heroin ; Chemical industry ; Diacetylmorphine ; Forensic Medicine - methods ; Forensic sciences ; Gas Chromatography-Mass Spectrometry ; General aspects ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Heroin ; Heroin - chemistry ; Heroin diluents ; Investigative techniques, diagnostic techniques (general aspects) ; Mannitol ; Mannitol - analogs & derivatives ; Mannitol - analysis ; Mannitol hexaacetate ; Medical sciences ; Molecular Structure ; Narcotics ; Narcotics - chemistry ; Nervous system (semeiology, syndromes) ; Neurology ; Nitrogen ; Street Drugs - chemistry ; Temperature</subject><ispartof>Forensic science international, 2004-10, Vol.145 (1), p.41-46</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 The Lancet Publishing Group, a division of Elsevier Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-5a26f0218200f393a903dfb34575ede2a85224fb45fd1f9f31c684675f174eba3</citedby><cites>FETCH-LOGICAL-c561t-5a26f0218200f393a903dfb34575ede2a85224fb45fd1f9f31c684675f174eba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033030699?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16147655$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15374593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Haj, B.M.</creatorcontrib><creatorcontrib>Al-Amri, A.M.</creatorcontrib><creatorcontrib>Ali, H.S.</creatorcontrib><title>Heroin profiling: mannitol hexaacetate as an unusual ingredient of some illicit drug seizures</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Mannitol hexaacetate (MHA) has been detected by GC–MS in some brown illicit drug seizures in which diacetylmorphine (DAM) was completely lacking. The presence of MHA as a genuine ingredient of the drug seizures rather than a storage- or an analytical artifact, formed by transacetylation of mannitol with the DAM in the heroin, has been verified. It is argued that MHA was formed as a result of the addition of mannitol, as diluent, before the acetylating step in the process of the heroin preparation. This early dilution in the production and distribution chain of the illicit drug is deemed as peculiar, nonetheless it may be highly indicative of a specific production process of heroin in a trafficking organization.</description><subject>Acetates</subject><subject>Biological and medical sciences</subject><subject>Brown heroin</subject><subject>Chemical industry</subject><subject>Diacetylmorphine</subject><subject>Forensic Medicine - methods</subject><subject>Forensic sciences</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General aspects</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Heroin</subject><subject>Heroin - chemistry</subject><subject>Heroin diluents</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mannitol</subject><subject>Mannitol - analogs & derivatives</subject><subject>Mannitol - analysis</subject><subject>Mannitol hexaacetate</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Narcotics</subject><subject>Narcotics - chemistry</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Nitrogen</subject><subject>Street Drugs - chemistry</subject><subject>Temperature</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk-LFDEQxYMo7rj6FTQgeus2fzpJt7dhUVdY8KJHCZl0ZcyQTtake1E_vRlncFAGlhxyyO9V1as8hF5Q0lJC5Ztd61Iu1vs4t4yQriW8JZQ9QCvaK9ZI1vOHaEW4GhqieH-BnpSyI4QIweRjdEEFV50Y-Ap9vYacfMS3OTkffNy-xZOJ0c8p4G_wwxgLs5kBm4JNxEtcymICrlyG0UOccXK4pAmwD8FbP-MxL1tcwP9aMpSn6JEzocCz432Jvrx_9_nqurn59OHj1fqmsULSuRGGSUcY7asVxwduBsJHt-GdUAJGYKYXjHVu0wk3Ujc4Tq3sO6mEo6qDjeGX6PWhbrXxfYEy68kXCyGYCGkpWsq-r_hwL0hVzxQjvIIv_wN3acmxmtC0PhNO5DCcqK0JoH10ac7G7kvqNeVMKTn8adqcobYQIZuQItTFw798e4avZ4TJ27MCdRDYnErJ4PRt9pPJP-usep8XvdN_86L3edGE65qXqnx-tLlsJhhPumNAKvDqCJhiTXDZROvLiZO0U1KIyq0PHNRvvvOQde0G0daUZLCzHpO_d5jfzurgVg</recordid><startdate>20041004</startdate><enddate>20041004</enddate><creator>El-Haj, B.M.</creator><creator>Al-Amri, A.M.</creator><creator>Ali, H.S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><general>The Lancet Publishing Group, a division of Elsevier Science Ltd</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ILT</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20041004</creationdate><title>Heroin profiling: mannitol hexaacetate as an unusual ingredient of some illicit drug seizures</title><author>El-Haj, B.M. ; Al-Amri, A.M. ; Ali, H.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-5a26f0218200f393a903dfb34575ede2a85224fb45fd1f9f31c684675f174eba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetates</topic><topic>Biological and medical sciences</topic><topic>Brown heroin</topic><topic>Chemical industry</topic><topic>Diacetylmorphine</topic><topic>Forensic Medicine - methods</topic><topic>Forensic sciences</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General aspects</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Heroin</topic><topic>Heroin - chemistry</topic><topic>Heroin diluents</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mannitol</topic><topic>Mannitol - analogs & derivatives</topic><topic>Mannitol - analysis</topic><topic>Mannitol hexaacetate</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Narcotics</topic><topic>Narcotics - chemistry</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Nitrogen</topic><topic>Street Drugs - chemistry</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Haj, B.M.</creatorcontrib><creatorcontrib>Al-Amri, A.M.</creatorcontrib><creatorcontrib>Ali, H.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale OneFile: LegalTrac</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Haj, B.M.</au><au>Al-Amri, A.M.</au><au>Ali, H.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heroin profiling: mannitol hexaacetate as an unusual ingredient of some illicit drug seizures</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2004-10-04</date><risdate>2004</risdate><volume>145</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><coden>FSINDR</coden><abstract>Mannitol hexaacetate (MHA) has been detected by GC–MS in some brown illicit drug seizures in which diacetylmorphine (DAM) was completely lacking. The presence of MHA as a genuine ingredient of the drug seizures rather than a storage- or an analytical artifact, formed by transacetylation of mannitol with the DAM in the heroin, has been verified. It is argued that MHA was formed as a result of the addition of mannitol, as diluent, before the acetylating step in the process of the heroin preparation. This early dilution in the production and distribution chain of the illicit drug is deemed as peculiar, nonetheless it may be highly indicative of a specific production process of heroin in a trafficking organization.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>15374593</pmid><doi>10.1016/j.forsciint.2004.03.012</doi><tpages>6</tpages></addata></record> |
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| ispartof | Forensic science international, 2004-10, Vol.145 (1), p.41-46 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Acetates Biological and medical sciences Brown heroin Chemical industry Diacetylmorphine Forensic Medicine - methods Forensic sciences Gas Chromatography-Mass Spectrometry General aspects Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Heroin Heroin - chemistry Heroin diluents Investigative techniques, diagnostic techniques (general aspects) Mannitol Mannitol - analogs & derivatives Mannitol - analysis Mannitol hexaacetate Medical sciences Molecular Structure Narcotics Narcotics - chemistry Nervous system (semeiology, syndromes) Neurology Nitrogen Street Drugs - chemistry Temperature |
| title | Heroin profiling: mannitol hexaacetate as an unusual ingredient of some illicit drug seizures |
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