Axillary recurrence after negative sentinel lymph node biopsy
Background Sentinel lymph node biopsy (SLNB) has almost totally replaced axillary lymph node dissection as the first-line axillary procedure for node-negative breast cancer. SLNB has a false-negative rate of 0-22%, and regional nodal recurrence is a major concern after SLNB. In this study, we assess...
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| Veröffentlicht in: | Breast cancer research and treatment 2009-03, Vol.114 (2), p.301-305 |
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| creator | Kim, Hee Jeong Son, Byung Ho Park, Eun Wha Lim, Woo Sung Seo, Jin Young Jang, Mi Ae Ku, Bo Kyong Ahn, Sei Hyun |
| description | Background Sentinel lymph node biopsy (SLNB) has almost totally replaced axillary lymph node dissection as the first-line axillary procedure for node-negative breast cancer. SLNB has a false-negative rate of 0-22%, and regional nodal recurrence is a major concern after SLNB. In this study, we assessed axillary recurrence and risk factors in breast cancer patients 40 months after negative SLNB. Methods Of 940 patients with node-negative breast cancer who underwent SLNB between December 2003 and January 2006 at Asan Medical Center, 720 were negative on SLNB, as determined using 99-m TC radiocolloid and subareolar injection technique. Of the 720 patients negative on SLNB, 174 underwent further axillary dissection, 253 underwent node sampling, and 293 received SLNB only. Results A mean of 2.1 SLNs was removed per patient. At a median follow-up of 40 months (range 24-49 months), recurrence in the axilla was observed in three patients, all of whom had undergone SLNB only; two of these patients also had recurrences in internal mammary lymph nodes. Tumors in all three patients were hormone-receptor negative, and two were c-erbb2 negative. Conclusion The axillary recurrence rate was low in patients negative on SLNB. Negative hormone-receptor status and high nuclear grade may be risk factors for regional nodal failure after SLNB. |
| doi_str_mv | 10.1007/s10549-008-9994-4 |
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SLNB has a false-negative rate of 0-22%, and regional nodal recurrence is a major concern after SLNB. In this study, we assessed axillary recurrence and risk factors in breast cancer patients 40 months after negative SLNB. Methods Of 940 patients with node-negative breast cancer who underwent SLNB between December 2003 and January 2006 at Asan Medical Center, 720 were negative on SLNB, as determined using 99-m TC radiocolloid and subareolar injection technique. Of the 720 patients negative on SLNB, 174 underwent further axillary dissection, 253 underwent node sampling, and 293 received SLNB only. Results A mean of 2.1 SLNs was removed per patient. At a median follow-up of 40 months (range 24-49 months), recurrence in the axilla was observed in three patients, all of whom had undergone SLNB only; two of these patients also had recurrences in internal mammary lymph nodes. Tumors in all three patients were hormone-receptor negative, and two were c-erbb2 negative. Conclusion The axillary recurrence rate was low in patients negative on SLNB. Negative hormone-receptor status and high nuclear grade may be risk factors for regional nodal failure after SLNB.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-008-9994-4</identifier><identifier>PMID: 18389366</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Adult ; Aged ; Axilla ; Biological and medical sciences ; Biopsy ; Breast cancer ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cancer research ; Cancer therapies ; Clinical Trial ; Clinical trials ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Lymph Node Excision ; Lymphatic system ; Mammary gland diseases ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - diagnostic imaging ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Oncology ; Prognosis ; Radionuclide Imaging ; relapse ; Risk factors ; Sentinel Lymph Node Biopsy ; Tumors</subject><ispartof>Breast cancer research and treatment, 2009-03, Vol.114 (2), p.301-305</ispartof><rights>Springer Science+Business Media, LLC. 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-34c15f8f9502ee03ce11c89f46c6827bf08e7056bc9777dbbe2b1ee9138bb55c3</citedby><cites>FETCH-LOGICAL-c454t-34c15f8f9502ee03ce11c89f46c6827bf08e7056bc9777dbbe2b1ee9138bb55c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-008-9994-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-008-9994-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21127840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18389366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hee Jeong</creatorcontrib><creatorcontrib>Son, Byung Ho</creatorcontrib><creatorcontrib>Park, Eun Wha</creatorcontrib><creatorcontrib>Lim, Woo Sung</creatorcontrib><creatorcontrib>Seo, Jin Young</creatorcontrib><creatorcontrib>Jang, Mi Ae</creatorcontrib><creatorcontrib>Ku, Bo Kyong</creatorcontrib><creatorcontrib>Ahn, Sei Hyun</creatorcontrib><title>Axillary recurrence after negative sentinel lymph node biopsy</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Background Sentinel lymph node biopsy (SLNB) has almost totally replaced axillary lymph node dissection as the first-line axillary procedure for node-negative breast cancer. SLNB has a false-negative rate of 0-22%, and regional nodal recurrence is a major concern after SLNB. In this study, we assessed axillary recurrence and risk factors in breast cancer patients 40 months after negative SLNB. Methods Of 940 patients with node-negative breast cancer who underwent SLNB between December 2003 and January 2006 at Asan Medical Center, 720 were negative on SLNB, as determined using 99-m TC radiocolloid and subareolar injection technique. Of the 720 patients negative on SLNB, 174 underwent further axillary dissection, 253 underwent node sampling, and 293 received SLNB only. Results A mean of 2.1 SLNs was removed per patient. At a median follow-up of 40 months (range 24-49 months), recurrence in the axilla was observed in three patients, all of whom had undergone SLNB only; two of these patients also had recurrences in internal mammary lymph nodes. Tumors in all three patients were hormone-receptor negative, and two were c-erbb2 negative. Conclusion The axillary recurrence rate was low in patients negative on SLNB. Negative hormone-receptor status and high nuclear grade may be risk factors for regional nodal failure after SLNB.</description><subject>Adult</subject><subject>Aged</subject><subject>Axilla</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Clinical Trial</subject><subject>Clinical trials</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymphatic system</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Radionuclide Imaging</subject><subject>relapse</subject><subject>Risk factors</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9v1DAQxS0EotvCB-ACEVK5pcz4vw89VBVQpEo9QM-W450sqbLJYieI_fZ4lRWVONDTHPybN8_vMfYG4QIBzMeMoKSrAWztnJO1fMZWqIyoDUfznK0Atam1BX3CTnN-AABnwL1kJ2iFdULrFbu8-t31fUj7KlGcU6IhUhXaiVI10CZM3S-qMg1TN1Bf9fvt7kc1jGuqmm7c5f0r9qINfabXx3nG7j9_-n59U9_effl6fXVbR6nkVAsZUbW2dQo4EYhIiNG6VuqoLTdNC5YMKN1EZ4xZNw3xBokcCts0SkVxxj4surs0_pwpT37b5UjF-EDjnL3W1irH5ZMgB4VKGV7A9_-AD-OchvIJz5FLBUocIFygmMacE7V-l7ptCcsj-EMDfmnAlwb8oQF_cPD2KDw3W1o_bhwjL8D5EQg5hr5NYYhd_stxRG6shMLxhcvladhQenT4v-vvlqU2jD5sUhG-_8YBBaByIEqifwB-P6X_</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Kim, Hee Jeong</creator><creator>Son, Byung Ho</creator><creator>Park, Eun Wha</creator><creator>Lim, Woo Sung</creator><creator>Seo, Jin Young</creator><creator>Jang, Mi Ae</creator><creator>Ku, Bo Kyong</creator><creator>Ahn, Sei Hyun</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Axillary recurrence after negative sentinel lymph node biopsy</title><author>Kim, Hee Jeong ; Son, Byung Ho ; Park, Eun Wha ; Lim, Woo Sung ; Seo, Jin Young ; Jang, Mi Ae ; Ku, Bo Kyong ; Ahn, Sei Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-34c15f8f9502ee03ce11c89f46c6827bf08e7056bc9777dbbe2b1ee9138bb55c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Axilla</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Clinical Trial</topic><topic>Clinical trials</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymphatic system</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - diagnostic imaging</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Radionuclide Imaging</topic><topic>relapse</topic><topic>Risk factors</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hee Jeong</creatorcontrib><creatorcontrib>Son, Byung Ho</creatorcontrib><creatorcontrib>Park, Eun Wha</creatorcontrib><creatorcontrib>Lim, Woo Sung</creatorcontrib><creatorcontrib>Seo, Jin Young</creatorcontrib><creatorcontrib>Jang, Mi Ae</creatorcontrib><creatorcontrib>Ku, Bo Kyong</creatorcontrib><creatorcontrib>Ahn, Sei Hyun</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hee Jeong</au><au>Son, Byung Ho</au><au>Park, Eun Wha</au><au>Lim, Woo Sung</au><au>Seo, Jin Young</au><au>Jang, Mi Ae</au><au>Ku, Bo Kyong</au><au>Ahn, Sei Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Axillary recurrence after negative sentinel lymph node biopsy</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>114</volume><issue>2</issue><spage>301</spage><epage>305</epage><pages>301-305</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Background Sentinel lymph node biopsy (SLNB) has almost totally replaced axillary lymph node dissection as the first-line axillary procedure for node-negative breast cancer. SLNB has a false-negative rate of 0-22%, and regional nodal recurrence is a major concern after SLNB. In this study, we assessed axillary recurrence and risk factors in breast cancer patients 40 months after negative SLNB. Methods Of 940 patients with node-negative breast cancer who underwent SLNB between December 2003 and January 2006 at Asan Medical Center, 720 were negative on SLNB, as determined using 99-m TC radiocolloid and subareolar injection technique. Of the 720 patients negative on SLNB, 174 underwent further axillary dissection, 253 underwent node sampling, and 293 received SLNB only. Results A mean of 2.1 SLNs was removed per patient. At a median follow-up of 40 months (range 24-49 months), recurrence in the axilla was observed in three patients, all of whom had undergone SLNB only; two of these patients also had recurrences in internal mammary lymph nodes. Tumors in all three patients were hormone-receptor negative, and two were c-erbb2 negative. Conclusion The axillary recurrence rate was low in patients negative on SLNB. Negative hormone-receptor status and high nuclear grade may be risk factors for regional nodal failure after SLNB.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>18389366</pmid><doi>10.1007/s10549-008-9994-4</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Axilla Biological and medical sciences Biopsy Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer research Cancer therapies Clinical Trial Clinical trials Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Lymph Node Excision Lymphatic system Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - pathology Neoplasm Staging Oncology Prognosis Radionuclide Imaging relapse Risk factors Sentinel Lymph Node Biopsy Tumors |
| title | Axillary recurrence after negative sentinel lymph node biopsy |
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