Bryostatin-1 enhances the maturation and antigen-presenting ability of murine and human dendritic cells

In this study, we investigated the effect of bryostatin-1 (Bryo-1), an antineoplastic agent, on dendritic cell (DC) maturation, activation, and functions. Murine bone marrow-derived DCs on culture with Bryo-1 alone, Bryo-1 + calcium ionophore (CI), but not CI alone exhibited morphologic changes char...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-09, Vol.64 (18), p.6756-6765
Hauptverfasser:	DO, Yoonkyung, HEGDE, Venkatesh L, NAGARKATTI, Prakash S, NAGARKATTI, Mitzi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Antigen Presentation - drug effects Antineoplastic agents Biological and medical sciences Bryostatins Dendritic Cells - drug effects Dendritic Cells - immunology Female Fetal Blood - cytology Humans Isoenzymes JNK Mitogen-Activated Protein Kinases Lactones - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Macrolides MAP Kinase Kinase 4 Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Pharmacology. Drug treatments Protein Kinase C - metabolism T-Lymphocytes - immunology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!