Bone healing induced by local delivery of an engineered parathyroid hormone prodrug

Abstract Regenerative medicine requires innovative therapeutic designs to accommodate high morphogen concentrations in local depots, provide their sustained presence, and enhance cellular invasion and directed differentiation. Here we present an example for inducing local bone regeneration with a ma...

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Veröffentlicht in:	Biomaterials 2009-03, Vol.30 (9), p.1763-1771
Hauptverfasser:	Arrighi, Isabelle, Mark, Silke, Alvisi, Monica, von Rechenberg, Brigitte, Hubbell, Jeffrey A, Schense, Jason C
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Biological Assay Bone and Bones - drug effects Bone and Bones - pathology Bone graft Bone healing Dentistry Drug Delivery Systems Electrophoresis, Polyacrylamide Gel Fibrin Fibrin - metabolism Fibrinolysin - metabolism Humans Osteoblast Parathyroid Hormone - administration & dosage Parathyroid Hormone - pharmacology Peptide Prodrugs - administration & dosage Prodrugs - pharmacology Receptors, Parathyroid Hormone - metabolism Sheep Transglutaminases - metabolism Wound Healing - drug effects
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