High-Efficiency Preparation of Macrocyclic Diblock Copolymers via Selective Click Reaction in Micellar Media

High-Efficiency Preparation of Macrocyclic Diblock Copolymers via Selective Click Reaction in Micellar Media

We report a novel strategy for the high-efficiency preparation of macrocyclic diblock copolymers at relatively high concentrations via the combination of supramolecular self-assembly and “selective” click reactions, relying on the fine control of spatial accessibility between terminal reactive group...

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Veröffentlicht in:Journal of the American Chemical Society 2009-02, Vol.131 (5), p.1628-1629
Hauptverfasser: Ge, Zhishen, Zhou, Yueming, Xu, Jian, Liu, Hewen, Chen, Daoyong, Liu, Shiyong
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container_end_page 1629
container_issue 5
container_start_page 1628
container_title Journal of the American Chemical Society
container_volume 131
creator Ge, Zhishen
Zhou, Yueming
Xu, Jian
Liu, Hewen
Chen, Daoyong
Liu, Shiyong
description We report a novel strategy for the high-efficiency preparation of macrocyclic diblock copolymers at relatively high concentrations via the combination of supramolecular self-assembly and “selective” click reactions, relying on the fine control of spatial accessibility between terminal reactive groups. The linear precursor, α-alkynyl-ω-azido heterodifunctional poly(2-(2-methoxyethoxy)ethyl methacrylate)-b-poly(oligo(ethylene glycol) methyl ether methacrylate), linear-PMEO2MA-b-POEGMA-N 3, self-assembles into micelles with PMEO2MA cores and POEGMA coronas at elevated temperatures. The spatial separation between reactive alkynyl and azide groups precludes click reactions within micelle entities. On the other hand, due to the unimer−micelle exchange equilibrium and the fact that unimer concentration is typically low (critical micellization concentration, CMC), click reactions occur exclusively for unimers. This eventually led to complete intramolecular cyclization of all linear precursors.
doi_str_mv 10.1021/ja808772z
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title High-Efficiency Preparation of Macrocyclic Diblock Copolymers via Selective Click Reaction in Micellar Media
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