On-Chip High-Pressure Picoliter Injector for Pressure-Driven Flow through Porous Media
A high-pressure (>3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 18...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2004-09, Vol.76 (17), p.5063-5068 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Reichmuth, David S. Shepodd, Timothy J. Kirby, Brian J. |
| description | A high-pressure (>3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with |
| doi_str_mv | 10.1021/ac0493572 |
| format | Article |
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The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with <250 ms duration. The injector operated robustly over 60 days and over 1000 injections. 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Chem</addtitle><description>A high-pressure (>3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with <250 ms duration. The injector operated robustly over 60 days and over 1000 injections. The injector is unique among polymer-based valves as it functions in aqueous, acetonitrile, and mixed buffers at high pressures without detectable leakage.</description><subject>Acrylates - chemistry</subject><subject>Analytical chemistry</subject><subject>Buffers</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Exact sciences and technology</subject><subject>Fluorocarbon Polymers - chemistry</subject><subject>General, instrumentation</subject><subject>Hydrostatic Pressure</subject><subject>Microfluidic Analytical Techniques - instrumentation</subject><subject>Other chromatographic methods</subject><subject>Photochemistry</subject><subject>Porosity</subject><subject>Pressure</subject><subject>Semiconductors</subject><subject>Silicon Dioxide - chemistry</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkNtqGzEURUVpSdwkD_2BMgRayIOao8uMNI_BaS6QNoY4eRWyfBTLHc840kwvfx8VuzGkAnFAZ7HZWoR8YPCFAWen1oGsRan4GzJiJQdaac3fkhEACMoVwD55n9ISgDFg1R7ZZ6VQQkoxIg-3LR0vwrq4Co8LOomY0hCxmATXNaHHWFy3S3R9Fwuf7789PY_hJ7bFRdP9KvpF7IbHRTHp8kzFN5wHe0jeedskPNrOA3J_8XU6vqI3t5fX47MbaqXiPXWaaY01SjHX5awEAbV3iMCsV0o7aVXtva9Efq9rIeyMiXxq1HPtoJQoDsjnTe46dk8Dpt6sQnLYNLbFXMZU2YQUkmXw-BW47IbY5m6GM5V1ceAZOtlALnYpRfRmHcPKxj-Ggflr2ryYzuzHbeAwW-F8R27VZuDTFrDJ2cZH27qQdlwFWtWyyhzdcCH1-Ptlb-MPUymhSjOd3BmoLqff2fmDKXe51qXdJ_4v-AxAnJ5V</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Reichmuth, David S.</creator><creator>Shepodd, Timothy J.</creator><creator>Kirby, Brian J.</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>On-Chip High-Pressure Picoliter Injector for Pressure-Driven Flow through Porous Media</title><author>Reichmuth, David S. ; 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Chem</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>76</volume><issue>17</issue><spage>5063</spage><epage>5068</epage><pages>5063-5068</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>A high-pressure (>3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with <250 ms duration. The injector operated robustly over 60 days and over 1000 injections. The injector is unique among polymer-based valves as it functions in aqueous, acetonitrile, and mixed buffers at high pressures without detectable leakage.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>15373443</pmid><doi>10.1021/ac0493572</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; ACS Publications |
| subjects | Acrylates - chemistry Analytical chemistry Buffers Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - instrumentation Exact sciences and technology Fluorocarbon Polymers - chemistry General, instrumentation Hydrostatic Pressure Microfluidic Analytical Techniques - instrumentation Other chromatographic methods Photochemistry Porosity Pressure Semiconductors Silicon Dioxide - chemistry |
| title | On-Chip High-Pressure Picoliter Injector for Pressure-Driven Flow through Porous Media |
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