PKCalpha regulates platelet granule secretion and thrombus formation in mice

Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the classical isoforms PKCalpha and PKCbeta and novel...

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Veröffentlicht in:	The Journal of clinical investigation 2009-02, Vol.119 (2), p.399-407
Hauptverfasser:	Konopatskaya, Olga, Gilio, Karen, Harper, Matthew T, Zhao, Yan, Cosemans, Judith M E M, Karim, Zubair A, Whiteheart, Sidney W, Molkentin, Jeffery D, Verkade, Paul, Watson, Steve P, Heemskerk, Johan W M, Poole, Alastair W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Animals Blood Platelets - secretion Blood Platelets - ultrastructure Cytoplasmic Granules - secretion Integrins - physiology Mice Platelet Aggregation - drug effects Protein Kinase C - physiology Protein Kinase C beta Protein Kinase C-alpha - physiology Signal Transduction Thrombosis - etiology
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