A Novel Human Her-2/neu Chimeric Molecule Expressed by Listeria monocytogenes Can Elicit Potent HLA-A2 Restricted CD8-positive T cell Responses and Impact the Growth and Spread of Her-2/neu-positive Breast Tumors

Purpose: The aim of this study was to efficiently design a novel vaccine for human Her-2/neu-positive (hHer-2/neu) breast cancer using the live, attenuated bacterial vector Listeria monocytogenes . Experimental Design: Three recombinant L. monocytogenes –based vaccines were generated that could expr...

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Veröffentlicht in:	Clinical cancer research 2009-02, Vol.15 (3), p.924-932
Hauptverfasser:	Seavey, Matthew M, Pan, Zhen-Kun, Maciag, Paulo C, Wallecha, Anu, Rivera, Sandra, Paterson, Yvonne, Shahabi, Vafa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, Neoplasm - immunology Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - therapy cancer Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD8-Positive T-Lymphocytes - immunology Genes, erbB-2 Genetic Vectors Her-2/neu HLA-A2 Antigen - immunology Humans immunotherapy Listeria Listeria monocytogenes - immunology Mice Molecular Sequence Data Neoplasm Transplantation Peptide Fragments - immunology vaccine Vaccines, Synthetic - therapeutic use
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