FXYD1, a Modulator of Na+,K+-ATPase Activity, Facilitates Female Sexual Development by Maintaining Gonadotrophin-Releasing Hormone Neuronal Excitability

The excitatory tone to gonadotrophin‐releasing hormone (GnRH) neurones is a critical component underlying the pubertal increase in GnRH secretion. However, the homeostatic mechanisms modulating the response of GnRH neurones to excitatory inputs remain poorly understood. A basic mechanism of neuronal...

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Veröffentlicht in:	Journal of neuroendocrinology 2009-02, Vol.21 (2), p.108-122
Hauptverfasser:	Garcia-Rudaz, C., Deng, V., Matagne, V., Ronnekleiv, O. K., Bosch, M., Han, V., Percy, A. K., Ojeda, S. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adolescent Animals Biological and medical sciences Child Child, Preschool Female female sexual development Fundamental and applied biological sciences. Psychology gene knockout GnRH neurones Gonadotropin-Releasing Hormone - metabolism Humans hypothalamus Hypothalamus - cytology Hypothalamus - metabolism Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - cytology Neurons - physiology Patch-Clamp Techniques Phosphoproteins - genetics Phosphoproteins - metabolism Puberty - physiology Rats Sexual Development - physiology Sodium-Potassium-Exchanging ATPase - metabolism Vertebrates: endocrinology
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