Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck
Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed...
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| Veröffentlicht in: | Clinical cancer research 2009-02, Vol.15 (3), p.986-994 |
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| creator | SUNGHEON KIM LOEVNER, Laurie QUON, Harry SHERMAN, Eric WEINSTEIN, Gregory KILGER, Alex POPTANI, Harish |
| description | Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection
of treatment response in head and neck squamous cell carcinomas (HNSCC).
Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during,
and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that
had incomplete data.
Results: Pretreatment ADC value of complete responders (1.04 ± 0.19 × 10 −3 mm 2 /s) was significantly lower ( P < 0.05) than that from partial responders (1.35 ± 0.30 × 10 −3 mm 2 /s). A significant increase in ADC was observed in complete responders within 1 week of treatment ( P < 0.01), which remained high until the end of the treatment. The complete responders also showed significantly higher increase
in ADC than the partial responders by the first week of chemoradiation ( P < 0.01). When pretreatment ADC value was used for predicting treatment response, the area under the receiver operating characteristic
curve was 0.80 with a sensitivity of 65% and a specificity of 86%. However, change in ADC within the first week of chemoradiation
therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and 83% specificity
for prediction of treatment response.
Conclusions: These results suggest that ADC can be used as a marker for prediction and early detection of response to concurrent chemoradiation
therapy in HNSCC. |
| doi_str_mv | 10.1158/1078-0432.CCR-08-1287 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66880353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66880353</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-28e4793c1dc7f1ef3f61433c8e259a86d3eebc779a1783e36c4eeea50ae1f5883</originalsourceid><addsrcrecordid>eNpFkc1u1TAQhSNERUvhEUDeAKsUTxwnzhKlhVYqPypFLK2pM74xJPGtnQjd9-FBcXovsLLH_s7M6JwsewH8DECqt8BrlfNSFGdte5NzlUOh6kfZCUhZ56Ko5ON0_8scZ09j_ME5lMDLJ9kxNKAU1Pwk-33urF2i81P-ndymn6ljH3Ez0ewMu6HoJ5wMsasRN27aMOsD-xKoc2ZeS5w6dk4z7asLDMNuFW39FInNnrU9jT5g53BOE9htTwG3O-Yt-3q_4OiXyFoaBtZiMG7yI8b1b-6JXRJ2D-0_kfn5LDuyOER6fjhPs2_vL27by_z684er9t11bkpVzHmhqKwbYaAztQWywlZQCmEUFbJBVXWC6M7UdYNQK0GiMiURoeRIYKVS4jR7ve-7Df5-oTjr0UWTFsSJ0q66qpTiQooEyj1ogo8xkNXb4EYMOw1cr_Ho1Xq9Wq9TPJqnhxRP0r08DFjuRur-qw55JODVAcBocLAhue_iP66AShY1FIl7s-f6lNkvF0ibNacQKFLystcgtdCNqsQf1jGozw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66880353</pqid></control><display><type>article</type><title>Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>SUNGHEON KIM ; LOEVNER, Laurie ; QUON, Harry ; SHERMAN, Eric ; WEINSTEIN, Gregory ; KILGER, Alex ; POPTANI, Harish</creator><creatorcontrib>SUNGHEON KIM ; LOEVNER, Laurie ; QUON, Harry ; SHERMAN, Eric ; WEINSTEIN, Gregory ; KILGER, Alex ; POPTANI, Harish</creatorcontrib><description>Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection
of treatment response in head and neck squamous cell carcinomas (HNSCC).
Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during,
and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that
had incomplete data.
Results: Pretreatment ADC value of complete responders (1.04 ± 0.19 × 10 −3 mm 2 /s) was significantly lower ( P < 0.05) than that from partial responders (1.35 ± 0.30 × 10 −3 mm 2 /s). A significant increase in ADC was observed in complete responders within 1 week of treatment ( P < 0.01), which remained high until the end of the treatment. The complete responders also showed significantly higher increase
in ADC than the partial responders by the first week of chemoradiation ( P < 0.01). When pretreatment ADC value was used for predicting treatment response, the area under the receiver operating characteristic
curve was 0.80 with a sensitivity of 65% and a specificity of 86%. However, change in ADC within the first week of chemoradiation
therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and 83% specificity
for prediction of treatment response.
Conclusions: These results suggest that ADC can be used as a marker for prediction and early detection of response to concurrent chemoradiation
therapy in HNSCC.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-08-1287</identifier><identifier>PMID: 19188170</identifier><identifier>CODEN: CCREF4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Antineoplastic agents ; apparent diffusion coefficient ; Biological and medical sciences ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - radiotherapy ; Combined Modality Therapy ; Diffusion Magnetic Resonance Imaging - methods ; diffusion-weighted imaging ; Early Diagnosis ; Female ; head and neck ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - drug therapy ; Head and Neck Neoplasms - radiotherapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Pharmacology. Drug treatments ; Prognosis ; radiation therapy ; Sensitivity and Specificity ; squamous cell carcinoma ; Treatment Outcome ; treatment response ; Tumors</subject><ispartof>Clinical cancer research, 2009-02, Vol.15 (3), p.986-994</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-28e4793c1dc7f1ef3f61433c8e259a86d3eebc779a1783e36c4eeea50ae1f5883</citedby><cites>FETCH-LOGICAL-c482t-28e4793c1dc7f1ef3f61433c8e259a86d3eebc779a1783e36c4eeea50ae1f5883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21652712$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19188170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUNGHEON KIM</creatorcontrib><creatorcontrib>LOEVNER, Laurie</creatorcontrib><creatorcontrib>QUON, Harry</creatorcontrib><creatorcontrib>SHERMAN, Eric</creatorcontrib><creatorcontrib>WEINSTEIN, Gregory</creatorcontrib><creatorcontrib>KILGER, Alex</creatorcontrib><creatorcontrib>POPTANI, Harish</creatorcontrib><title>Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection
of treatment response in head and neck squamous cell carcinomas (HNSCC).
Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during,
and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that
had incomplete data.
Results: Pretreatment ADC value of complete responders (1.04 ± 0.19 × 10 −3 mm 2 /s) was significantly lower ( P < 0.05) than that from partial responders (1.35 ± 0.30 × 10 −3 mm 2 /s). A significant increase in ADC was observed in complete responders within 1 week of treatment ( P < 0.01), which remained high until the end of the treatment. The complete responders also showed significantly higher increase
in ADC than the partial responders by the first week of chemoradiation ( P < 0.01). When pretreatment ADC value was used for predicting treatment response, the area under the receiver operating characteristic
curve was 0.80 with a sensitivity of 65% and a specificity of 86%. However, change in ADC within the first week of chemoradiation
therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and 83% specificity
for prediction of treatment response.
Conclusions: These results suggest that ADC can be used as a marker for prediction and early detection of response to concurrent chemoradiation
therapy in HNSCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>apparent diffusion coefficient</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Combined Modality Therapy</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>diffusion-weighted imaging</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>head and neck</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>radiation therapy</subject><subject>Sensitivity and Specificity</subject><subject>squamous cell carcinoma</subject><subject>Treatment Outcome</subject><subject>treatment response</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1TAQhSNERUvhEUDeAKsUTxwnzhKlhVYqPypFLK2pM74xJPGtnQjd9-FBcXovsLLH_s7M6JwsewH8DECqt8BrlfNSFGdte5NzlUOh6kfZCUhZ56Ko5ON0_8scZ09j_ME5lMDLJ9kxNKAU1Pwk-33urF2i81P-ndymn6ljH3Ez0ewMu6HoJ5wMsasRN27aMOsD-xKoc2ZeS5w6dk4z7asLDMNuFW39FInNnrU9jT5g53BOE9htTwG3O-Yt-3q_4OiXyFoaBtZiMG7yI8b1b-6JXRJ2D-0_kfn5LDuyOER6fjhPs2_vL27by_z684er9t11bkpVzHmhqKwbYaAztQWywlZQCmEUFbJBVXWC6M7UdYNQK0GiMiURoeRIYKVS4jR7ve-7Df5-oTjr0UWTFsSJ0q66qpTiQooEyj1ogo8xkNXb4EYMOw1cr_Ho1Xq9Wq9TPJqnhxRP0r08DFjuRur-qw55JODVAcBocLAhue_iP66AShY1FIl7s-f6lNkvF0ibNacQKFLystcgtdCNqsQf1jGozw</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>SUNGHEON KIM</creator><creator>LOEVNER, Laurie</creator><creator>QUON, Harry</creator><creator>SHERMAN, Eric</creator><creator>WEINSTEIN, Gregory</creator><creator>KILGER, Alex</creator><creator>POPTANI, Harish</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck</title><author>SUNGHEON KIM ; LOEVNER, Laurie ; QUON, Harry ; SHERMAN, Eric ; WEINSTEIN, Gregory ; KILGER, Alex ; POPTANI, Harish</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-28e4793c1dc7f1ef3f61433c8e259a86d3eebc779a1783e36c4eeea50ae1f5883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>apparent diffusion coefficient</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Combined Modality Therapy</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>diffusion-weighted imaging</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>head and neck</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>radiation therapy</topic><topic>Sensitivity and Specificity</topic><topic>squamous cell carcinoma</topic><topic>Treatment Outcome</topic><topic>treatment response</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUNGHEON KIM</creatorcontrib><creatorcontrib>LOEVNER, Laurie</creatorcontrib><creatorcontrib>QUON, Harry</creatorcontrib><creatorcontrib>SHERMAN, Eric</creatorcontrib><creatorcontrib>WEINSTEIN, Gregory</creatorcontrib><creatorcontrib>KILGER, Alex</creatorcontrib><creatorcontrib>POPTANI, Harish</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUNGHEON KIM</au><au>LOEVNER, Laurie</au><au>QUON, Harry</au><au>SHERMAN, Eric</au><au>WEINSTEIN, Gregory</au><au>KILGER, Alex</au><au>POPTANI, Harish</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>15</volume><issue>3</issue><spage>986</spage><epage>994</epage><pages>986-994</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><coden>CCREF4</coden><abstract>Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection
of treatment response in head and neck squamous cell carcinomas (HNSCC).
Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during,
and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that
had incomplete data.
Results: Pretreatment ADC value of complete responders (1.04 ± 0.19 × 10 −3 mm 2 /s) was significantly lower ( P < 0.05) than that from partial responders (1.35 ± 0.30 × 10 −3 mm 2 /s). A significant increase in ADC was observed in complete responders within 1 week of treatment ( P < 0.01), which remained high until the end of the treatment. The complete responders also showed significantly higher increase
in ADC than the partial responders by the first week of chemoradiation ( P < 0.01). When pretreatment ADC value was used for predicting treatment response, the area under the receiver operating characteristic
curve was 0.80 with a sensitivity of 65% and a specificity of 86%. However, change in ADC within the first week of chemoradiation
therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and 83% specificity
for prediction of treatment response.
Conclusions: These results suggest that ADC can be used as a marker for prediction and early detection of response to concurrent chemoradiation
therapy in HNSCC.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19188170</pmid><doi>10.1158/1078-0432.CCR-08-1287</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cancer research, 2009-02, Vol.15 (3), p.986-994 |
| issn | 1078-0432 1557-3265 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Antineoplastic agents apparent diffusion coefficient Biological and medical sciences Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy Combined Modality Therapy Diffusion Magnetic Resonance Imaging - methods diffusion-weighted imaging Early Diagnosis Female head and neck Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - radiotherapy Humans Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Prognosis radiation therapy Sensitivity and Specificity squamous cell carcinoma Treatment Outcome treatment response Tumors |
| title | Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting Early Response to Chemoradiation Therapy of Squamous Cell Carcinomas of the Head and Neck |
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