Gefitinib reverses breast cancer resistance protein–mediated drug resistance

Breast cancer resistance protein (BCRP) is an ATP binding cassette transporter that confers resistance to a series of anticancer agents such as 7-ethyl-10-hydroxycamptothecin (SN-38), topotecan, and mitoxantrone. In this study, we evaluated the possible interaction of gefitinib, a selective epiderma...

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Veröffentlicht in:	Molecular cancer therapeutics 2004-09, Vol.3 (9), p.1119-1125
Hauptverfasser:	Yanase, Kae, Tsukahara, Satomi, Asada, Sakiyo, Ishikawa, Etsuko, Imai, Yasuo, Sugimoto, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological Transport - drug effects Camptothecin - analogs & derivatives Camptothecin - pharmacology Cell Line, Tumor Drug Resistance, Neoplasm - genetics Estrone - analogs & derivatives Estrone - metabolism Humans Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Quinazolines - pharmacology Topotecan - metabolism
Online-Zugang:	Volltext
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