Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial

Summary Background Palonosetron is a second-generation 5-hydroxytryptamine 3 (5-HT3 )-receptor antagonist that has shown better efficacy than ondansetron and dolasetron in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy, and similar...

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Veröffentlicht in:	The lancet oncology 2009-02, Vol.10 (2), p.115-124
Hauptverfasser:	Saito, Mitsue, Dr, Aogi, Kenjiro, MD, Sekine, Ikuo, MD, Yoshizawa, Hirohisa, MD, Yanagita, Yasuhiro, MD, Sakai, Hiroshi, MD, Inoue, Kenichi, MD, Kitagawa, Chiyoe, MD, Ogura, Takashi, MD, Mitsuhashi, Shoichi, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiemetics - therapeutic use Antineoplastic Agents - adverse effects Dexamethasone - therapeutic use Double-Blind Method Female Granisetron - therapeutic use Hematology, Oncology and Palliative Medicine Humans Isoquinolines - therapeutic use Male Middle Aged Nausea - chemically induced Nausea - prevention & control Neoplasms - drug therapy Quinuclidines - therapeutic use Serotonin Antagonists - therapeutic use Vomiting - chemically induced Vomiting - prevention & control
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